                                                 Toxicology Data Management System                                     Page: 1
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058813803  08/16/99   729       50(3)      22  (681)    501.7     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634803  06/06/96   726      100(3)      52  (681)    492.7     CITRAL                                     |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(3)      23  (662)    519.6     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812206  06/25/97   727       50(3)      26  (667)    483.6     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805005  10/30/95   729       50(3)      25  (665)    488.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   729       50(3)      24  (659)    496.8     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   729       50(3)      29  (665)    502.2     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611103  09/08/97   731      100(3)      60  (689)    492.1     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058813803  08/16/99   729       50(5)      32  (688)    348.7     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634803  06/06/96   732      100(5)      75  (705)    335.2     CITRAL                                     |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(5)      30  (683)    350.8     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812206  06/25/97   728       50(5)      30  (672)    327.2     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805005  10/30/95   731       50(5)      38  (710)    315.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   730       50(5)      36  (694)    330.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   730       50(5)      33  (695)    350.1     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611103  09/08/97   735      100(5)      70  (706)    344.4     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302607  08/14/97   733       50( )      28  (684)    506.2     DECALIN                                    |
|BATTELLE NORTHWEST 058812403  01/18/96   733       50( )      27  (667)    501.0     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   733       49( )      24  (681)    507.1     NAPHTHALENE                                |
|BATTELLE NORTHWEST 059000407  10/06/97   729       50( )      27  (675)    540.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600105  01/18/99   729       50( )      29  (701)    534.2     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142707  01/06/97   729       50( )      20  (668)    518.0     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302607  08/14/97   734       50( )      32  (700)    345.9     DECALIN                                    |
|BATTELLE NORTHWEST 058812403  01/18/96   735       50( )      34  (682)    337.2     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   734       49( )      28  (700)    325.2     NAPHTHALENE                                |
|BATTELLE NORTHWEST 059000407  10/06/97   730       50( )      33  (675)    366.9     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600105  01/18/99   730       50( )      36  (696)    362.8     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142707  01/06/97   731       50( )      33  (688)    351.1     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902905  09/26/94   736      100(5)      57  (692)    498.3     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902905  09/26/94   737      100(5)      59  (692)    338.0     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302306  07/11/97   729       50(3)      37  (693)    510.6     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201205  07/15/98   729       50(3)      35  (704)    446.9     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601003  09/16/98   729       50(3)      36  (687)    514.1     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  050520308  02/08/96   729       60(3)      39  (698)    447.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(3)      31  (697)    443.8     P-NITROTOLUENE                             |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302306  07/11/97   732       50(5)      37  (699)    314.6     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201205  07/15/98   734       50(5)      40  (707)    320.6     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601003  09/16/98   734       50(5)      37  (699)    341.7     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  050520308  02/08/96   730       60(5)      47  (713)    299.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(5)      39  (702)    295.2     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516105  03/06/96   729       50(5)      33  (683)    322.1     RIDDELLIINE                                |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       49/50 (98%)   97/100(97%)   47/50 (94%)         42/50 (84%)   78/100(78%)   44/50 (88%)    |
|                                       49/50 (98%)   47/50 (94%)   42/50 (84%)         37/50 (74%)   35/50 (70%)   37/50 (74%)    |
|                                       47/50 (94%)   99/100(99%)                       42/50 (84%)   78/100(78%)                  |
| Overall Incidence               Total 477/500 (95.4%) Mean 94.75%  SD 4.8%      Total 393/500 (78.6%)  Mean 78.75%  SD 6.14%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    33/50 (66%)   76/100(76%)   35/50 (70%)         20/50 (40%)   30/100(30%)   25/50 (50%)    |
|                                       29/50 (58%)   29/50 (58%)   34/50 (68%)         12/50 (24%)   26/50 (52%)   16/50 (32%)    |
|                                       30/50 (60%)   57/100(57%)                       23/50 (46%)   39/100(39%)                  |
| Overall Incidence               Total 323/500 (64.6%) Mean 64.13%  SD 6.94%     Total 191/500 (38.2%)  Mean 39.13%  SD 9.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)  99/100(99%)   49/50 (98%)         46/50 (92%)   92/100(92%)   50/50 (100%)   |
|                                       49/50 (98%)   49/50 (98%)   49/50 (98%)         42/50 (84%)   45/50 (90%)   43/50 (86%)    |
|                                       49/50 (98%)  100/100(100%)                      45/50 (90%)   92/100(92%)                  |
| Overall Incidence               Total 494/500 (98.8%) Mean 98.63%  SD 0.92%     Total 455/500 (91%)    Mean 90.75%  SD 4.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 2/500 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 3/500 (0.6%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   27/50 (54%)   68/100(68%)   16/50 (32%)         19/50 (38%)   24/100(24%)   10/50 (20%)    |
|      Mononuclear, or Undifferentiated 15/50 (30%)   20/50 (40%)   27/50 (54%)          7/50 (14%)   21/50 (42%)    8/50 (16%)    |
|                                       17/50 (34%)   40/100(40%)                       15/50 (30%)   21/100(21%)                  |
| Overall Incidence               Total 230/500 (46%)   Mean 44%     SD 13.35%    Total 125/500 (25%)    Mean 25.63%  SD 10.17%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 2/500 (0.4%)     Mean 0.25%   SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     2/50 (4%)     4/100(4%)     6/50 (12%)          0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      NOS                               2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     5/100(5%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 24/500 (4.8%)   Mean 4.88%   SD 3.36%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              2/50 (4%)     4/100(4%)     6/50 (12%)          0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     5/100(5%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 24/500 (4.8%)   Mean 4.88%   SD 3.36%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.75%   SD 1.04%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.75%   SD 1.04%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     2/100(2%)     0/47 (0%)           0/50 (0%)     2/100(2%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 3/497 (0.6%)    Mean 0.5%    SD 0.93%     Total 9/499 (1.8%)     Mean 1.88%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/100(0%)     1/47 (2%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.39%   SD 0.78%     Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              8/50 (16%)   10/100(10%)    4/47 (9%)           0/50 (0%)     3/99 (3%)     0/49 (0%)     |
|                                        7/50 (14%)    3/50 (6%)     4/50 (8%)           2/50 (4%)     1/50 (2%)     2/50 (4%)     |
|                                        6/50 (12%)    5/100(5%)                         4/50 (8%)     1/100(1%)                   |
| Overall Incidence               Total 47/497 (9.46%)  Mean 9.94%   SD 3.84%     Total 13/498 (2.61%)   Mean 2.75%   SD 2.66%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     1/100(1%)     0/47 (0%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 1/497 (0.2%)    Mean 0.13%   SD 0.35%     Total 1/498 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/100(0%)     5/47 (11%)          0/50 (0%)     0/99 (0%)     2/49 (4%)     |
|                                        1/50 (2%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 10/497 (2.01%)  Mean 2.58%   SD 3.54%     Total 5/498 (1%)       Mean 1.01%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            8/50 (16%)   11/100(11%)    9/47 (19%)          0/50 (0%)     3/99 (3%)     2/49 (4%)     |
|      Complex, Malignant, NOS           7/50 (14%)    4/50 (8%)     6/50 (12%)          3/50 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        7/50 (14%)    5/100(5%)                         4/50 (8%)     4/100(4%)                   |
| Overall Incidence               Total 57/497 (11.47%) Mean 12.39%  SD 4.47%     Total 19/498 (3.82%)   Mean 3.89%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 3/500 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     7/100(7%)     3/50 (6%)           3/50 (6%)    15/98 (15%)    6/48 (13%)    |
|                                        1/50 (2%)     2/50 (4%)     3/50 (6%)           3/50 (6%)     2/49 (4%)     1/47 (2%)     |
|                                        0/50 (0%)     7/100(7%)                         8/46 (17%)    4/99 (4%)                   |
| Overall Incidence               Total 23/500 (4.6%)   Mean 4%      SD 2.98%     Total 42/487 (8.62%)   Mean 8.43%   SD 5.78%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/50 (2%)     1/100(1%)     3/50 (6%)           1/50 (2%)     1/98 (1%)     5/48 (10%)    |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/47 (0%)     |
|                                        5/50 (10%)    4/100(4%)                         2/46 (4%)     9/99 (9%)                   |
| Overall Incidence               Total 16/500 (3.2%)   Mean 3.38%   SD 3.25%     Total 19/487 (3.9%)    Mean 3.61%   SD 4.05%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)     8/100(8%)     6/50 (12%)          4/50 (8%)    16/98 (16%)   10/48 (21%)    |
|                                        2/50 (4%)     3/50 (6%)     3/50 (6%)           3/50 (6%)     3/49 (6%)     1/47 (2%)     |
|                                        5/50 (10%)   11/100(11%)                       10/46 (22%)   13/99 (13%)                  |
| Overall Incidence               Total 39/500 (7.8%)   Mean 7.38%   SD 3.5%      Total 60/487 (12.32%)  Mean 11.79%  SD 7.33%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/47 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/46 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/487 (0.21%)    Mean 0.26%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/98 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/46 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/487 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/46 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/487 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/98 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/46 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/487 (0.21%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/100(0%)     2/50 (4%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 1.41%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.75%   SD 1.04%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)     3/99 (3%)     2/44 (5%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 13/493 (2.64%)  Mean 2.7%    SD 2.61%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/99 (0%)     0/44 (0%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 2/493 (0.41%)   Mean 0.5%    SD 0.93%     Total 2/497 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     3/99 (3%)     2/44 (5%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    2/100(2%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 15/493 (3.04%)  Mean 3.2%    SD 3.03%     Total 2/497 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/100(0%)     1/47 (2%)           0/50 (0%)     1/100(1%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.52%   SD 0.96%     Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     1/100(1%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/100(0%)     1/47 (2%)           0/50 (0%)     2/100(2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.52%   SD 0.96%     Total 2/499 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/100(0%)     1/47 (2%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/497 (0.2%)    Mean 0.27%   SD 0.75%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 5/500 (1%)      Mean 1%      SD 1.51%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 1.41%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 1.41%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Hepatocellular Adenoma            0/50 (0%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 7/500 (1.4%)    Mean 1.5%    SD 1.77%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        0/50 (0%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 7/500 (1.4%)    Mean 1.5%    SD 1.77%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         4/50 (8%)     3/100(3%)     2/50 (4%)           4/50 (8%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     4/100(4%)                         3/50 (6%)     6/100(6%)                   |
| Overall Incidence               Total 17/500 (3.4%)   Mean 3.38%   SD 2.56%     Total 15/500 (3%)      Mean 2.75%   SD 3.37%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.88%   SD 1.46%     Total 3/500 (0.6%)     Mean 0.5%    SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    4/50 (8%)     3/100(3%)     3/50 (6%)           4/50 (8%)     3/100(3%)     1/50 (2%)     |
|      Alveolar/Bronchiolar Adenoma      2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/100(5%)                         3/50 (6%)     7/100(7%)                   |
| Overall Incidence               Total 21/500 (4.2%)   Mean 4.25%   SD 2.31%     Total 18/500 (3.6%)    Mean 3.25%   SD 3.33%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     1/100(1%)     0/50 (0%)           2/50 (4%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         2/50 (4%)     1/100(1%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 7/500 (1.4%)     Mean 1.63%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     4/50 (8%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.71%     Total 11/500 (2.2%)    Mean 2.63%   SD 2.88%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     3/100(3%)     0/50 (0%)           2/50 (4%)     0/100(0%)     4/50 (8%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        0/50 (0%)     0/100(0%)                         2/50 (4%)     2/100(2%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.63%   SD 1.19%     Total 16/500 (3.2%)    Mean 3.75%   SD 2.49%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)     8/100(8%)     1/50 (2%)          27/50 (54%)   53/100(53%)   36/50 (72%)    |
|                                        2/50 (4%)     2/50 (4%)     3/50 (6%)          15/50 (30%)   21/50 (42%)   15/50 (30%)    |
|                                        3/50 (6%)     3/100(3%)                        21/50 (42%)   55/100(55%)                  |
| Overall Incidence               Total 24/500 (4.8%)   Mean 4.63%   SD 1.92%     Total 243/500 (48.6%)  Mean 47.25%  SD 14.15%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     2/50 (4%)     9/100(9%)     1/50 (2%)          28/50 (56%)   53/100(53%)   36/50 (72%)    |
|                                        4/50 (8%)     2/50 (4%)     3/50 (6%)          15/50 (30%)   21/50 (42%)   16/50 (32%)    |
|                                        3/50 (6%)     3/100(3%)                        23/50 (46%)   55/100(55%)                  |
| Overall Incidence               Total 27/500 (5.4%)   Mean 5.25%   SD 2.43%     Total 247/500 (49.4%)  Mean 48.25%  SD 13.8%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    2/50 (4%)    11/100(11%)    1/50 (2%)          28/50 (56%)   53/100(53%)   37/50 (74%)    |
|      or Adenoma                        4/50 (8%)     2/50 (4%)     3/50 (6%)          16/50 (32%)   23/50 (46%)   16/50 (32%)    |
|                                        3/50 (6%)     3/100(3%)                        23/50 (46%)   56/100(56%)                  |
| Overall Incidence               Total 29/500 (5.8%)   Mean 5.5%    SD 2.93%     Total 252/500 (50.4%)  Mean 49.38%  SD 13.8%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     1/100(1%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 1/498 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.5%    SD 0.76%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.46%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     2/100(2%)     0/50 (0%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/100(2%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 5/500 (1%)      Mean 0.75%   SD 1.04%     Total 3/500 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.46%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     2/100(2%)     0/44 (0%)           0/50 (0%)     0/100(0%)     1/47 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 5/494 (1.01%)   Mean 0.88%   SD 1.46%     Total 2/497 (0.4%)     Mean 0.52%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/100(0%)     1/44 (2%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/494 (0.2%)    Mean 0.28%   SD 0.8%      Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     2/100(2%)     1/44 (2%)           0/50 (0%)     0/100(0%)     1/47 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 6/494 (1.21%)   Mean 1.16%   SD 1.48%     Total 2/497 (0.4%)     Mean 0.52%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)     1/100(1%)     0/44 (0%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/494 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   1/50 (2%)     0/100(0%)     2/44 (5%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/494 (0.81%)   Mean 0.94%   SD 1.63%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/49 (0%)     0/93 (0%)     1/45 (2%)           0/47 (0%)     2/86 (2%)     0/49 (0%)     |
|                                        0/46 (0%)     0/46 (0%)     0/46 (0%)           1/46 (2%)     1/48 (2%)     0/45 (0%)     |
|                                        0/45 (0%)     0/92 (0%)                         0/46 (0%)     0/90 (0%)                   |
| Overall Incidence               Total 1/462 (0.22%)   Mean 0.28%   SD 0.79%     Total 4/457 (0.88%)    Mean 0.82%   SD 1.14%     |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      10/50 (20%)   17/100(17%)   15/47 (32%)         17/50 (34%)   29/100(29%)   20/48 (42%)    |
|   Adenoma                             19/50 (38%)   17/50 (34%)   11/50 (22%)         21/50 (42%)   12/50 (24%)   23/50 (46%)    |
|                                       13/50 (26%)   21/100(21%)                       24/50 (48%)   35/100(35%)                  |
| Overall Incidence               Total 123/497 (24.75%)Mean 26.24%  SD 7.56%     Total 181/498 (36.35%) Mean 37.46%  SD 8.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     1/48 (2%)     |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/497 (0.2%)    Mean 0.25%   SD 0.71%     Total 2/498 (0.4%)     Mean 0.51%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      10/50 (20%)   17/100(17%)   15/47 (32%)         17/50 (34%)   29/100(29%)   21/48 (44%)    |
|   Carcinoma or Adenoma                20/50 (40%)   17/50 (34%)   11/50 (22%)         21/50 (42%)   13/50 (26%)   23/50 (46%)    |
|                                       13/50 (26%)   21/100(21%)                       24/50 (48%)   35/100(35%)                  |
| Overall Incidence               Total 124/497 (24.95%)Mean 26.49%  SD 8.03%     Total 183/498 (36.75%) Mean 37.97%  SD 8.13%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     1/100(1%)     0/47 (0%)           0/50 (0%)     2/100(2%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.38%   SD 0.74%     Total 2/498 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     0/47 (0%)           0/50 (0%)     2/100(2%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.38%   SD 0.74%     Total 2/498 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     1/48 (2%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     4/100(4%)                                                                   |
| Overall Incidence               Total 6/498 (1.2%)    Mean 1.01%   SD 1.52%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     1/48 (2%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     4/100(4%)                                                                   |
| Overall Incidence               Total 6/498 (1.2%)    Mean 1.01%   SD 1.52%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 1/498 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 1/498 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/49 (2%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/100(0%)                   |
| Overall Incidence               Total 6/498 (1.2%)    Mean 1.51%   SD 1.77%     Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.75%   SD 0.89%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.75%   SD 0.89%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Tumor Benign, or                  1/50 (2%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     2/100(2%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 7/500 (1.4%)    Mean 1.25%   SD 1.49%     Total 3/500 (0.6%)     Mean 0.75%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              1/50 (2%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       1/50 (2%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    1/50 (2%)     3/100(3%)                         2/50 (4%)     0/100(0%)                   |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 9/500 (1.8%)    Mean 1.63%   SD 1.51%     Total 4/500 (0.8%)     Mean 1%      SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        11/50 (22%)   11/100(11%)    1/50 (2%)           3/50 (6%)     1/100(1%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    4/50 (8%)     2/50 (4%)     6/50 (12%)          1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  3/50 (6%)     8/100(8%)                         3/50 (6%)     0/100(0%)                   |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 46/500 (9.2%)   Mean 9.13%   SD 6.17%     Total 10/500 (2%)      Mean 2.38%   SD 2.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                     10/50 (20%)    8/100(8%)     1/50 (2%)           3/50 (6%)     0/100(0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/100(5%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 32/500 (6.4%)   Mean 6.38%   SD 5.85%     Total 3/500 (0.6%)     Mean 0.75%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 5/500 (1%)      Mean 1.25%   SD 1.04%     Total 4/500 (0.8%)     Mean 0.75%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      1/50 (2%)     1/100(1%)                         2/50 (4%)     0/100(0%)                   |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.63%   SD 0.92%     Total 2/500 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.88%   SD 0.99%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|      Papilloma                         1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.88%   SD 0.99%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/50 (22%)    9/100(9%)     1/50 (2%)           3/50 (6%)     1/100(1%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          3/50 (6%)     2/50 (4%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      2/50 (4%)     5/100(5%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 37/500 (7.4%)   Mean 7.5%    SD 6.28%     Total 6/500 (1.2%)     Mean 1.38%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/50 (22%)    9/100(9%)     1/50 (2%)           3/50 (6%)     1/100(1%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     3/50 (6%)     1/50 (2%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     5/100(5%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 36/500 (7.2%)   Mean 7.25%   SD 6.48%     Total 5/500 (1%)       Mean 1.13%   SD 2.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.5%    SD 0.76%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              5/50 (10%)    2/100(2%)     6/50 (12%)          3/50 (6%)     1/100(1%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     7/100(7%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 26/500 (5.2%)   Mean 5.38%   SD 4.17%     Total 8/500 (1.6%)     Mean 1.75%   SD 1.91%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      6/50 (12%)    8/100(8%)     9/50 (18%)          4/50 (8%)     1/100(1%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   3/50 (6%)     3/50 (6%)     4/50 (8%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Histiocytoma                      1/50 (2%)    12/100(12%)                        1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 46/500 (9.2%)   Mean 9%      SD 4.9%      Total 10/500 (2%)      Mean 2.25%   SD 2.43%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     2/100(2%)     0/50 (0%)           1/50 (2%)     0/100(0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     6/100(6%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 11/500 (2.2%)   Mean 1.75%   SD 2.25%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     5/100(5%)     3/50 (6%)           1/50 (2%)     0/100(0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Histiocytoma                      1/50 (2%)     6/100(6%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 20/500 (4%)     Mean 3.63%   SD 2.13%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 1/50 (2%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.75%   SD 1.04%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     1/100(1%)     3/50 (6%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 5/500 (1%)      Mean 1.13%   SD 2.1%      Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/43 (0%)           0/49 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/493 (0%)      Mean 0%      SD 0%        Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     2/50 (4%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 2/500 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 2/500 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             45/50 (90%)   96/100(96%)   45/50 (90%)                                                    |
|                                       44/50 (88%)   40/50 (80%)   41/50 (82%)                                                    |
|                                       47/50 (94%)   91/100(91%)                                                                  |
| Overall Incidence               Total 449/500 (89.8%) Mean 88.88%  SD 5.49%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)                                                                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/48 (0%)     0/97 (0%)     0/39 (0%)           0/50 (0%)     0/96 (0%)     1/48 (2%)     |
|                                        0/45 (0%)     0/49 (0%)     0/46 (0%)           0/45 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     1/87 (1%)                         0/49 (0%)     0/92 (0%)                   |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.14%   SD 0.41%     Total 1/474 (0.21%)    Mean 0.26%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/48 (0%)     0/97 (0%)     0/39 (0%)           0/50 (0%)     0/96 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/46 (0%)           0/45 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     0/87 (0%)                         0/49 (0%)     1/92 (1%)                   |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 1/474 (0.21%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/48 (0%)     0/97 (0%)     0/39 (0%)           0/50 (0%)     0/96 (0%)     1/48 (2%)     |
|                                        0/45 (0%)     0/49 (0%)     0/46 (0%)           0/45 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     1/87 (1%)                         0/49 (0%)     1/92 (1%)                   |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.14%   SD 0.41%     Total 2/474 (0.42%)    Mean 0.4%    SD 0.78%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             10/50 (20%)   12/100(12%)    4/42 (10%)          4/50 (8%)    21/100(21%)    6/45 (13%)    |
|                                        8/50 (16%)    9/50 (18%)    8/50 (16%)         11/50 (22%)    3/50 (6%)     5/50 (10%)    |
|                                       12/50 (24%)   12/100(12%)                        7/50 (14%)   11/100(11%)                  |
| Overall Incidence               Total 75/492 (15.24%) Mean 15.94%  SD 4.75%     Total 68/495 (13.74%)  Mean 13.17%  SD 5.77%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)     4/100(4%)     2/42 (5%)           0/50 (0%)     0/100(0%)     1/45 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     2/50 (4%)     |
|                                        2/50 (4%)     3/100(3%)                         2/50 (4%)     3/100(3%)                   |
| Overall Incidence               Total 15/492 (3.05%)  Mean 2.97%   SD 1.56%     Total 10/495 (2.02%)   Mean 2.15%   SD 1.88%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                11/50 (22%)   16/100(16%)    6/42 (14%)          4/50 (8%)    21/100(21%)    7/45 (16%)    |
|                                       10/50 (20%)   10/50 (20%)    8/50 (16%)         11/50 (22%)    5/50 (10%)    7/50 (14%)    |
|                                       14/50 (28%)   15/100(15%)                        9/50 (18%)   14/100(14%)                  |
| Overall Incidence               Total 90/492 (18.29%) Mean 18.91%  SD 4.6%      Total 78/495 (15.76%)  Mean 15.32%  SD 4.92%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)     3/100(3%)     1/42 (2%)           0/50 (0%)     0/100(0%)     0/45 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/100(1%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 9/492 (1.83%)   Mean 1.8%    SD 1.4%      Total 3/495 (0.61%)    Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     1/100(1%)     0/42 (0%)           0/50 (0%)     1/100(1%)     1/45 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     3/100(3%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 7/492 (1.42%)   Mean 1.25%   SD 1.58%     Total 5/495 (1.01%)    Mean 1.15%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     4/100(4%)     1/42 (2%)           0/50 (0%)     1/100(1%)     1/45 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     4/100(4%)                         2/50 (4%)     1/100(1%)                   |
| Overall Incidence               Total 16/492 (3.25%)  Mean 3.05%   SD 1.48%     Total 8/495 (1.62%)    Mean 1.78%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.5%    SD 0.76%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.5%    SD 0.76%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/495 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/49 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/495 (0.2%)    Mean 0.26%   SD 0.72%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/495 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/49 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/495 (0.2%)    Mean 0.26%   SD 0.72%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     1/46 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/495 (0.2%)    Mean 0.27%   SD 0.77%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     0/100(0%)                   |
| Overall Incidence                                                               Total 2/500 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        6/50 (12%)   19/100(19%)    8/50 (16%)    |
|                                                                                        7/50 (14%)    7/50 (14%)   10/50 (20%)    |
|                                                                                        7/50 (14%)   14/100(14%)                  |
| Overall Incidence                                                               Total 78/500 (15.6%)   Mean 15.38%  SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     6/50 (12%)   19/100(19%)    9/50 (18%)    |
|                                                                                        7/50 (14%)    7/50 (14%)   11/50 (22%)    |
|                                                                                        7/50 (14%)   14/100(14%)                  |
| Overall Incidence                                                               Total 80/500 (16%)     Mean 15.88%  SD 3.4%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     1/100(1%)     3/50 (6%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 6/500 (1.2%)    Mean 1.38%   SD 2.07%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     3/50 (6%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 6/500 (1.2%)    Mean 1.38%   SD 2.07%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 35
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       47/50 (94%)   47/50 (94%)   46/49 (94%)         46/50 (92%)   44/50 (88%)   38/49 (78%)    |
|                                       50/50 (100%)  50/50 (100%)  48/50 (96%)         41/50 (82%)   37/50 (74%)   41/50 (82%)    |
| Overall Incidence               Total 288/299 (96.32%)Mean 96.31%  SD 2.96%     Total 247/299 (82.61%) Mean 82.59%  SD 6.6%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    27/50 (54%)   26/50 (52%)   34/49 (69%)         25/50 (50%)   25/50 (50%)   26/49 (53%)    |
|                                       35/50 (70%)   33/50 (66%)   28/50 (56%)         33/50 (66%)   30/50 (60%)   28/50 (56%)    |
| Overall Incidence               Total 183/299 (61.2%) Mean 61.23%  SD 8.14%     Total 167/299 (55.85%) Mean 55.84%  SD 6.27%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         49/50 (98%)   49/50 (98%)   48/49 (98%)         49/50 (98%)   49/50 (98%)   44/49 (90%)    |
|                                       50/50 (100%)  50/50 (100%)  50/50 (100%)        49/50 (98%)   44/50 (88%)   47/50 (94%)    |
| Overall Incidence               Total 296/299 (99%)   Mean 98.99%  SD 1.1%      Total 282/299 (94.31%) Mean 94.3%   SD 4.5%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 3/299 (1%)       Mean 1.01%   SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   19/50 (38%)   16/50 (32%)   26/49 (53%)         11/50 (22%)   14/50 (28%)   16/49 (33%)    |
|      Mononuclear, or Undifferentiated 33/50 (66%)   25/50 (50%)   22/50 (44%)         24/50 (48%)   26/50 (52%)   21/50 (42%)    |
| Overall Incidence               Total 141/299 (47.16%)Mean 47.18%  SD 12.01%    Total 112/299 (37.46%) Mean 37.44%  SD 11.79%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     2/50 (4%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      NOS                               2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.68%   SD 1.65%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/299 (2.01%)   Mean 2%      SD 1.79%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.67%   SD 2.06%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.67%   SD 2.06%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     1/49 (2%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.68%   SD 1.67%     Total 4/296 (1.35%)    Mean 1.36%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/296 (0.68%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/49 (14%)   10/50 (20%)    4/49 (8%)           1/50 (2%)     2/50 (4%)     3/48 (6%)     |
|                                       12/50 (24%)    5/50 (10%)    4/50 (8%)           2/49 (4%)     2/50 (4%)     2/49 (4%)     |
| Overall Incidence               Total 42/298 (14.09%) Mean 14.07%  SD 6.67%     Total 12/296 (4.05%)   Mean 4.07%   SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/49 (4%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 7/298 (2.35%)   Mean 2.35%   SD 1.52%     Total 1/296 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            8/49 (16%)   10/50 (20%)    5/49 (10%)          1/50 (2%)     2/50 (4%)     3/48 (6%)     |
|      Complex, Malignant, NOS          14/50 (28%)    6/50 (12%)    5/50 (10%)          2/49 (4%)     3/50 (6%)     2/49 (4%)     |
| Overall Incidence               Total 48/298 (16.11%) Mean 16.09%  SD 7.01%     Total 13/296 (4.39%)   Mean 4.4%    SD 1.56%     |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.67%   SD 2.06%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     3/50 (6%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.67%   SD 2.06%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/297 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|      Astrocytoma                       0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/297 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     3/48 (6%)           8/48 (17%)    5/49 (10%)    4/49 (8%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 5/298 (1.68%)   Mean 1.71%   SD 2.43%     Total 20/295 (6.78%)   Mean 6.84%   SD 6.13%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     2/50 (4%)     3/48 (6%)           1/48 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 6/298 (2.01%)   Mean 2.04%   SD 2.61%     Total 4/295 (1.36%)    Mean 1.35%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     3/50 (6%)     6/48 (13%)          9/48 (19%)    5/49 (10%)    4/49 (8%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     1/49 (2%)     2/50 (4%)     |
| Overall Incidence               Total 11/298 (3.69%)  Mean 3.75%   SD 4.98%     Total 24/295 (8.14%)   Mean 8.19%   SD 5.93%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)     1/50 (2%)     2/49 (4%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|                                        4/50 (8%)     3/50 (6%)     1/50 (2%)           0/49 (0%)     1/49 (2%)     1/49 (2%)     |
| Overall Incidence               Total 14/299 (4.68%)  Mean 4.68%   SD 2.42%     Total 5/296 (1.69%)    Mean 1.69%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            4/50 (8%)     2/50 (4%)     4/49 (8%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/49 (2%)     0/49 (0%)     1/49 (2%)     |
| Overall Incidence               Total 12/299 (4.01%)  Mean 4.03%   SD 3.39%     Total 4/296 (1.35%)    Mean 1.35%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 7/50 (14%)    3/50 (6%)     6/49 (12%)          2/50 (4%)     1/50 (2%)     2/49 (4%)     |
|                                        4/50 (8%)     4/50 (8%)     2/50 (4%)           1/49 (2%)     1/49 (2%)     2/49 (4%)     |
| Overall Incidence               Total 26/299 (8.7%)   Mean 8.71%   SD 3.77%     Total 9/296 (3.04%)    Mean 3.04%   SD 1.11%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/299 (1%)      Mean 1%      SD 1.1%      Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/296 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 1.03%     Total 1/296 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/296 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        3/50 (6%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.34%   SD 2.42%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatocellular Adenoma            3/50 (6%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 5/299 (1.67%)   Mean 1.68%   SD 2.67%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Hepatocellular Adenoma, or        3/50 (6%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 5/299 (1.67%)   Mean 1.68%   SD 2.67%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)     6/50 (12%)    2/49 (4%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     4/50 (8%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 14/299 (4.68%)  Mean 4.68%   SD 4.5%      Total 2/297 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 1.03%     Total 2/297 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    2/50 (4%)     7/50 (14%)    2/49 (4%)           2/50 (4%)     1/50 (2%)     1/49 (2%)     |
|      Alveolar/Bronchiolar Adenoma      1/50 (2%)     2/50 (4%)     4/50 (8%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 18/299 (6.02%)  Mean 6.01%   SD 4.37%     Total 4/297 (1.35%)    Mean 1.34%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     1/49 (2%)           5/50 (10%)    0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    4/50 (8%)     2/50 (4%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 19/299 (6.35%)   Mean 6.35%   SD 3.88%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     1/49 (2%)           5/50 (10%)    0/50 (0%)     3/49 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    4/50 (8%)     3/50 (6%)     |
| Overall Incidence               Total 3/299 (1%)      Mean 1.01%   SD 1.68%     Total 20/299 (6.69%)   Mean 6.69%   SD 3.72%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)     2/50 (4%)     0/49 (0%)          25/50 (50%)   20/50 (40%)   17/49 (35%)    |
|                                        2/50 (4%)     3/50 (6%)     2/50 (4%)          25/50 (50%)   19/50 (38%)   16/50 (32%)    |
| Overall Incidence               Total 11/299 (3.68%)  Mean 3.67%   SD 1.97%     Total 122/299 (40.8%)  Mean 40.78%  SD 7.65%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     2/50 (4%)     0/49 (0%)          25/50 (50%)   20/50 (40%)   17/49 (35%)    |
|                                        2/50 (4%)     3/50 (6%)     2/50 (4%)          25/50 (50%)   19/50 (38%)   17/50 (34%)    |
| Overall Incidence               Total 12/299 (4.01%)  Mean 4%      SD 2.19%     Total 123/299 (41.14%) Mean 41.12%  SD 7.22%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    4/50 (8%)     2/50 (4%)     1/49 (2%)          29/50 (58%)   20/50 (40%)   18/49 (37%)    |
|      or Adenoma                        2/50 (4%)     3/50 (6%)     2/50 (4%)          27/50 (54%)   23/50 (46%)   19/50 (38%)    |
| Overall Incidence               Total 14/299 (4.68%)  Mean 4.67%   SD 2.06%     Total 136/299 (45.48%) Mean 45.46%  SD 8.86%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.34%   SD 0.83%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/297 (0.34%)   Mean 0.33%   SD 0.82%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/49 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/297 (0.34%)   Mean 0.33%   SD 0.82%     Total 1/297 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     1/50 (2%)     0/49 (0%)           3/50 (6%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 3/299 (1%)       Mean 1%      SD 2.45%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     2/49 (4%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/299 (0.67%)    Mean 0.68%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|      Malignant, NOS                                                                    0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/299 (1%)       Mean 1.01%   SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 3/299 (1%)       Mean 1.01%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/49 (0%)     1/44 (2%)     0/45 (0%)           0/49 (0%)     0/40 (0%)     0/42 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/45 (0%)     |
| Overall Incidence               Total 1/286 (0.35%)   Mean 0.38%   SD 0.93%     Total 0/274 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      27/50 (54%)   36/49 (73%)   31/49 (63%)         34/50 (68%)   30/50 (60%)   23/49 (47%)    |
|   Adenoma                             35/50 (70%)   38/50 (76%)   35/50 (70%)         30/49 (61%)   27/49 (55%)   31/49 (63%)    |
| Overall Incidence               Total 202/298 (67.79%)Mean 67.79%  SD 8%        Total 175/296 (59.12%) Mean 59.09%  SD 7.29%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     1/49 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/298 (0.67%)   Mean 0.67%   SD 1.04%     Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      27/50 (54%)   37/49 (76%)   31/49 (63%)         34/50 (68%)   30/50 (60%)   23/49 (47%)    |
|   Carcinoma or Adenoma                35/50 (70%)   39/50 (78%)   35/50 (70%)         30/49 (61%)   27/49 (55%)   31/49 (63%)    |
| Overall Incidence               Total 204/298 (68.46%)Mean 68.46%  SD 8.74%     Total 175/296 (59.12%) Mean 59.09%  SD 7.29%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/298 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/299 (2.01%)   Mean 2.01%   SD 2.19%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        1/50 (2%)     3/50 (6%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/299 (2.01%)   Mean 2.01%   SD 2.19%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         3/50 (6%)     2/50 (4%)     4/49 (8%)           1/50 (2%)     1/50 (2%)     1/49 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    2/50 (4%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 17/299 (5.69%)  Mean 5.69%   SD 2.97%     Total 4/299 (1.34%)    Mean 1.34%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 12/299 (4.01%)  Mean 4.03%   SD 3.39%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/299 (2.34%)   Mean 2.34%   SD 1.5%      Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     1/50 (2%)     0/49 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 1.03%     Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Papilloma                         1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/299 (1.34%)   Mean 1.33%   SD 1.03%     Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
|      Papilloma, Squamous Cell          2/50 (4%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 16/299 (5.35%)  Mean 5.36%   SD 3.04%     Total 3/299 (1%)       Mean 1.01%   SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     2/50 (4%)     4/49 (8%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|      Papilloma, or Keratoacanthoma     2/50 (4%)     1/50 (2%)     5/50 (10%)          0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 16/299 (5.35%)  Mean 5.36%   SD 3.04%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/50 (4%)     1/50 (2%)     5/49 (10%)          0/50 (0%)     3/50 (6%)     0/49 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 14/299 (4.68%)  Mean 4.7%    SD 2.81%     Total 5/299 (1.67%)    Mean 1.67%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      4/50 (8%)     2/50 (4%)     7/49 (14%)          2/50 (4%)     3/50 (6%)     1/49 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   3/50 (6%)     3/50 (6%)     6/50 (12%)          3/50 (6%)     0/50 (0%)     1/50 (2%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 25/299 (8.36%)  Mean 8.38%   SD 3.97%     Total 10/299 (3.34%)   Mean 3.34%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/50 (4%)     1/50 (2%)     2/49 (4%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 8/299 (2.68%)   Mean 2.68%   SD 1.05%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               2/50 (4%)     1/50 (2%)     2/49 (4%)           2/50 (4%)     0/50 (0%)     1/49 (2%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     1/50 (2%)     4/50 (8%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 11/299 (3.68%)  Mean 3.68%   SD 2.34%     Total 5/299 (1.67%)    Mean 1.67%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.63%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/297 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             40/50 (80%)   40/50 (80%)   38/49 (78%)                                                    |
|                                       41/50 (82%)   41/50 (82%)   36/50 (72%)                                                    |
| Overall Incidence               Total 236/299 (78.93%)Mean 78.93%  SD 3.77%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     0/49 (0%)     0/49 (0%)           0/45 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/280 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     1/49 (2%)     0/49 (0%)           0/45 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/289 (0.35%)   Mean 0.34%   SD 0.83%     Total 0/280 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)     0/47 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/47 (0%)     1/49 (2%)     0/49 (0%)           0/45 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/289 (0.35%)   Mean 0.34%   SD 0.83%     Total 0/280 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              7/50 (14%)    5/49 (10%)    9/46 (20%)          5/50 (10%)    6/47 (13%)    4/47 (9%)     |
|                                        3/50 (6%)     7/50 (14%)    1/50 (2%)           8/49 (16%)    3/49 (6%)     2/50 (4%)     |
| Overall Incidence               Total 32/295 (10.85%) Mean 10.96%  SD 6.29%     Total 28/292 (9.59%)   Mean 9.62%   SD 4.47%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     1/49 (2%)     1/46 (2%)           3/50 (6%)     3/47 (6%)     3/47 (6%)     |
|                                        1/50 (2%)     2/50 (4%)     0/50 (0%)           2/49 (4%)     1/49 (2%)     1/50 (2%)     |
| Overall Incidence               Total 5/295 (1.69%)   Mean 1.7%    SD 1.52%     Total 13/292 (4.45%)   Mean 4.48%   SD 2.09%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 7/50 (14%)    6/49 (12%)   10/46 (22%)          8/50 (16%)    8/47 (17%)    7/47 (15%)    |
|                                        4/50 (8%)     9/50 (18%)    1/50 (2%)           9/49 (18%)    4/49 (8%)     3/50 (6%)     |
| Overall Incidence               Total 37/295 (12.54%) Mean 12.66%  SD 7.05%     Total 39/292 (13.36%)  Mean 13.41%  SD 5.08%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     0/47 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     1/47 (2%)     1/47 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/295 (0.68%)   Mean 0.67%   SD 1.03%     Total 4/292 (1.37%)    Mean 1.38%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/46 (0%)           0/50 (0%)     1/47 (2%)     1/47 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     2/50 (4%)     |
| Overall Incidence               Total 2/295 (0.68%)   Mean 0.67%   SD 1.03%     Total 4/292 (1.37%)    Mean 1.38%   SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 1/295 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     1/49 (2%)     1/50 (2%)     |
| Overall Incidence               Total 1/297 (0.34%)   Mean 0.35%   SD 0.85%     Total 3/295 (1.02%)    Mean 1.02%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 1/295 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     1/48 (2%)           0/50 (0%)     0/49 (0%)     1/48 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/297 (0.34%)   Mean 0.35%   SD 0.85%     Total 2/295 (0.68%)    Mean 0.69%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/297 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        7/50 (14%)   10/50 (20%)   15/49 (31%)    |
|                                                                                        5/50 (10%)   10/50 (20%)    6/50 (12%)    |
| Overall Incidence                                                               Total 53/299 (17.73%)  Mean 17.77%  SD 7.52%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     7/50 (14%)   10/50 (20%)   15/49 (31%)    |
|                                                                                        5/50 (10%)   11/50 (22%)    6/50 (12%)    |
| Overall Incidence                                                               Total 54/299 (18.06%)  Mean 18.1%   SD 7.68%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 6/299 (2.01%)    Mean 2.01%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     2/49 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 6/299 (2.01%)    Mean 2.01%   SD 1.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       99/100(99%)                                     92/100(92%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    66/100(66%)                                     40/100(40%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors        100/100(100%)                                    98/100(98%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   50/100(50%)                                     20/100(20%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/100(0%)                                       0/100(0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/100(4%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/100(4%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/99 (0%)                                       6/100(6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             24/98 (24%)                                      7/96 (7%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           26/98 (27%)                                      7/96 (7%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        2/100(2%)                                       2/100(2%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                             13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/99 (3%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            1/99 (1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/99 (4%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)                                       0/100(0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/100(3%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/100(3%)                                       4/100(4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    6/100(6%)                                      58/100(58%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/100(0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/85 (0%)                                       1/88 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     61/99 (62%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/98 (0%)                                       3/99 (3%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     64/99 (65%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   3/100(3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                3/100(3%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     3/100(3%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     3/100(3%)                                       0/100(0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        14/100(14%)                                      1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                     10/100(10%)                                      1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       0/100(0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                             12/100(12%)                                      4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,     13/100(13%)                                      6/100(6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/100(1%)                                       2/100(2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       0/100(0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       0/100(0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             93/100(93%)                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            1/100(1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             15/99 (15%)                                     15/100(15%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/99 (1%)                                       5/100(5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                16/99 (16%)                                     19/100(19%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

                                                This page intentionally left blank
                                                 Toxicology Data Management System                                     Page: 79
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       48/50 (96%)   49/50 (98%)   48/50 (96%)         45/50 (90%)   43/50 (86%)   46/50 (92%)    |
|                                       60/60 (100%)  49/50 (98%)                       47/60 (78%)   33/50 (66%)   45/50 (90%)    |
| Overall Incidence               Total 254/260 (97.69%)Mean 97.6%   SD 1.67%     Total 259/310 (83.55%) Mean 83.72%  SD 9.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    21/50 (42%)   22/50 (44%)   27/50 (54%)         18/50 (36%)   19/50 (38%)   21/50 (42%)    |
|                                       37/60 (62%)   33/50 (66%)                       24/60 (40%)   22/50 (44%)   20/50 (40%)    |
| Overall Incidence               Total 140/260 (53.85%)Mean 53.53%  SD 10.56%    Total 124/310 (40%)    Mean 40%     SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)  50/50 (100%)  49/50 (98%)         47/50 (94%)   45/50 (90%)   49/50 (98%)    |
|                                       60/60 (100%)  50/50 (100%)                      54/60 (90%)   43/50 (86%)   47/50 (94%)    |
| Overall Incidence               Total 259/260 (99.62%)Mean 99.6%   SD 0.89%     Total 285/310 (91.94%) Mean 92%     SD 4.2%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     2/50 (4%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.79%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.73%   SD 1.01%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     2/50 (4%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 4/260 (1.54%)   Mean 1.53%   SD 1.66%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/260 (1.15%)   Mean 1.13%   SD 1.04%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   11/50 (22%)   15/50 (30%)   13/50 (26%)         10/50 (20%)    6/50 (12%)   11/50 (22%)    |
|      Mononuclear, or Undifferentiated 30/60 (50%)   24/50 (48%)                       21/60 (35%)   13/50 (26%)   12/50 (24%)    |
| Overall Incidence               Total 93/260 (35.77%) Mean 35.2%   SD 12.93%    Total 73/310 (23.55%)  Mean 23.17%  SD 7.55%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/60 (0%)     2/50 (4%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 3/260 (1.15%)   Mean 1.2%    SD 1.79%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/50 (8%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               2/60 (3%)     5/50 (10%)                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 13/260 (5%)     Mean 5.07%   SD 3.96%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/50 (8%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/60 (3%)     5/50 (10%)                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 13/260 (5%)     Mean 5.07%   SD 3.96%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.79%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/260 (1.54%)   Mean 1.53%   SD 2.6%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     2/50 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/260 (2.31%)   Mean 2.33%   SD 2.62%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     5/50 (10%)    0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         2/60 (3%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/259 (0.39%)   Mean 0.4%    SD 0.89%     Total 9/310 (2.9%)     Mean 2.89%   SD 3.72%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/259 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/259 (0%)      Mean 0%      SD 0%        Total 0/308 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/50 (14%)    8/50 (16%)    6/49 (12%)          1/50 (2%)     0/49 (0%)     2/50 (4%)     |
|                                        2/60 (3%)     3/50 (6%)                         2/60 (3%)     2/49 (4%)     1/50 (2%)     |
| Overall Incidence               Total 26/259 (10.04%) Mean 10.32%  SD 5.41%     Total 8/308 (2.6%)     Mean 2.57%   SD 1.56%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/259 (0%)      Mean 0%      SD 0%        Total 0/308 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     3/49 (6%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        2/60 (3%)     0/50 (0%)                         0/60 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 5/259 (1.93%)   Mean 1.89%   SD 2.77%     Total 2/308 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            7/50 (14%)    8/50 (16%)    9/49 (18%)          2/50 (4%)     0/49 (0%)     2/50 (4%)     |
|      Complex, Malignant, NOS           4/60 (7%)     3/50 (6%)                         2/60 (3%)     2/49 (4%)     2/50 (4%)     |
| Overall Incidence               Total 31/259 (11.97%) Mean 12.21%  SD 5.59%     Total 10/308 (3.25%)   Mean 3.24%   SD 1.61%     |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.79%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.73%   SD 1.01%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     2/50 (4%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/260 (1.54%)   Mean 1.53%   SD 1.66%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 3/309 (0.97%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/49 (0%)     |
|      Astrocytoma                       0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 3/309 (0.97%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/309 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              1/49 (2%)     0/50 (0%)     1/48 (2%)           5/50 (10%)    5/50 (10%)   11/49 (22%)    |
|                                        2/60 (3%)     2/50 (4%)                        12/59 (20%)    7/50 (14%)    7/49 (14%)    |
| Overall Incidence               Total 6/257 (2.33%)   Mean 2.29%   SD 1.53%     Total 47/307 (15.31%)  Mean 15.18%  SD 5.2%      |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            3/49 (6%)     0/50 (0%)     3/48 (6%)           2/50 (4%)     3/50 (6%)     3/49 (6%)     |
|                                        2/60 (3%)     2/50 (4%)                         2/59 (3%)     2/50 (4%)     3/49 (6%)     |
| Overall Incidence               Total 10/257 (3.89%)  Mean 3.94%   SD 2.55%     Total 15/307 (4.89%)   Mean 4.94%   SD 1.27%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 4/49 (8%)     0/50 (0%)     4/48 (8%)           7/50 (14%)    8/50 (16%)   14/49 (29%)    |
|                                        4/60 (7%)     4/50 (8%)                        14/59 (24%)    8/50 (16%)   10/49 (20%)    |
| Overall Incidence               Total 16/257 (6.23%)  Mean 6.23%   SD 3.55%     Total 61/307 (19.87%)  Mean 19.78%  SD 5.57%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/257 (0%)      Mean 0%      SD 0%        Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/257 (0%)      Mean 0%      SD 0%        Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/60 (0%)     1/50 (2%)                         0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/257 (0.39%)   Mean 0.4%    SD 0.89%     Total 0/307 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/49 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/59 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/257 (0%)      Mean 0%      SD 0%        Total 1/307 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.33%   SD 0.75%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              4/50 (8%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        2/60 (3%)     3/50 (6%)                         1/60 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 12/260 (4.62%)  Mean 4.67%   SD 3.09%     Total 6/310 (1.94%)    Mean 1.94%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        0/60 (0%)     2/50 (4%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/260 (1.54%)   Mean 1.6%    SD 2.19%     Total 3/310 (0.97%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/50 (8%)     0/50 (0%)     5/50 (10%)          1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|                                        2/60 (3%)     5/50 (10%)                        1/60 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 16/260 (6.15%)  Mean 6.27%   SD 4.44%     Total 9/310 (2.9%)     Mean 2.94%   SD 2.13%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/47 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/47 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/49 (0%)     0/47 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/256 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/60 (3%)     0/50 (0%)                         1/60 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.67%   SD 1.49%     Total 3/310 (0.97%)    Mean 0.94%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.73%   SD 1.01%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    1/60 (2%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.73%   SD 1.01%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Hepatocellular Adenoma            3/60 (5%)     1/50 (2%)                         1/60 (2%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 4/260 (1.54%)   Mean 1.4%    SD 2.19%     Total 3/310 (0.97%)    Mean 0.94%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        3/60 (5%)     1/50 (2%)                         1/60 (2%)     0/50 (0%)     1/50 (2%)     |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 4/260 (1.54%)   Mean 1.4%    SD 2.19%     Total 3/310 (0.97%)    Mean 0.94%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)     2/50 (4%)     1/50 (2%)           3/50 (6%)     0/50 (0%)     1/50 (2%)     |
|                                        1/60 (2%)     1/50 (2%)                         1/60 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 6/260 (2.31%)   Mean 2.33%   SD 0.94%     Total 7/310 (2.26%)    Mean 2.28%   SD 2.35%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     2/50 (4%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/260 (2.31%)   Mean 2.33%   SD 2.62%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    1/50 (2%)     4/50 (8%)     4/50 (8%)           3/50 (6%)     0/50 (0%)     2/50 (4%)     |
|      Alveolar/Bronchiolar Adenoma      2/60 (3%)     1/50 (2%)                         1/60 (2%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 12/260 (4.62%)  Mean 4.67%   SD 3.09%     Total 8/310 (2.58%)    Mean 2.61%   SD 2.44%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     3/50 (6%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 6/310 (1.94%)    Mean 2%      SD 2.53%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     4/50 (8%)     3/50 (6%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.79%     Total 12/310 (3.87%)   Mean 4%      SD 2.83%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     4/50 (8%)     6/50 (12%)    |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     3/50 (6%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.79%     Total 17/310 (5.48%)   Mean 5.67%   SD 4.27%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         3/50 (6%)     0/50 (0%)     2/50 (4%)          22/50 (44%)   26/50 (52%)   33/50 (66%)    |
|                                        0/60 (0%)     0/50 (0%)                        23/60 (38%)   14/50 (28%)   28/50 (56%)    |
| Overall Incidence               Total 5/260 (1.92%)   Mean 2%      SD 2.83%     Total 146/310 (47.1%)  Mean 47.39%  SD 13.5%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     0/50 (0%)     2/50 (4%)          23/50 (46%)   26/50 (52%)   35/50 (70%)    |
|                                        0/60 (0%)     0/50 (0%)                        23/60 (38%)   14/50 (28%)   28/50 (56%)    |
| Overall Incidence               Total 5/260 (1.92%)   Mean 2%      SD 2.83%     Total 149/310 (48.06%) Mean 48.39%  SD 14.56%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    5/50 (10%)    0/50 (0%)     2/50 (4%)          24/50 (48%)   28/50 (56%)   37/50 (74%)    |
|      or Adenoma                        0/60 (0%)     0/50 (0%)                        23/60 (38%)   14/50 (28%)   30/50 (60%)    |
| Overall Incidence               Total 7/260 (2.69%)   Mean 2.8%    SD 4.38%     Total 156/310 (50.32%) Mean 50.72%  SD 16.33%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/259 (0.39%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/259 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/60 (0%)     0/50 (0%)                         0/60 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 3/310 (0.97%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Malignant, NOS                                                                    0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                             10/50 (20%)    1/49 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 12/258 (4.65%)  Mean 4.74%   SD 8.58%     Total 4/310 (1.29%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/258 (0.39%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                10/50 (20%)    1/49 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     2/50 (4%)     |
|                                        1/60 (2%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 13/258 (5.04%)  Mean 5.14%   SD 8.35%     Total 4/310 (1.29%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/258 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/258 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/47 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/58 (0%)     0/48 (0%)                         0/57 (0%)     0/46 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/252 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      12/50 (24%)    9/50 (18%)   16/48 (33%)         19/50 (38%)   23/50 (46%)   23/49 (47%)    |
|   Adenoma                             11/59 (19%)   15/48 (31%)                       19/59 (32%)   15/50 (30%)   27/50 (54%)    |
| Overall Incidence               Total 63/255 (24.71%) Mean 25.05%  SD 7.05%     Total 126/308 (40.91%) Mean 41.19%  SD 9.34%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     2/50 (4%)     1/49 (2%)     |
|   Carcinoma                            0/59 (0%)     1/48 (2%)                         0/59 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/255 (0.39%)   Mean 0.42%   SD 0.93%     Total 3/308 (0.97%)    Mean 1.01%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      12/50 (24%)    9/50 (18%)   16/48 (33%)         19/50 (38%)   25/50 (50%)   24/49 (49%)    |
|   Carcinoma or Adenoma                11/59 (19%)   16/48 (33%)                       19/59 (32%)   15/50 (30%)   27/50 (54%)    |
| Overall Incidence               Total 64/255 (25.1%)  Mean 25.46%  SD 7.55%     Total 129/308 (41.88%) Mean 42.2%   SD 10.12%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 92
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/59 (0%)     0/48 (0%)                         1/59 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/255 (0.39%)   Mean 0.4%    SD 0.89%     Total 3/308 (0.97%)    Mean 0.96%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     1/49 (2%)     |
|                                        0/59 (0%)     0/48 (0%)                         1/59 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/255 (0.39%)   Mean 0.4%    SD 0.89%     Total 3/308 (0.97%)    Mean 0.96%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              2/49 (4%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        2/60 (3%)     2/50 (4%)                                                                   |
| Overall Incidence               Total 6/259 (2.32%)   Mean 2.28%   SD 2.1%                                                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 2/49 (4%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        2/60 (3%)     2/50 (4%)                                                                   |
| Overall Incidence               Total 6/259 (2.32%)   Mean 2.28%   SD 2.1%                                                       |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/259 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/259 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/259 (0.77%)   Mean 0.8%    SD 1.1%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 93
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/60 (3%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/260 (1.15%)   Mean 1.07%   SD 1.53%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         2/60 (3%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/260 (1.15%)   Mean 1.07%   SD 1.53%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
|      Tumor Benign, or                  2/60 (3%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 6/260 (2.31%)   Mean 2.27%   SD 0.6%      Total 3/310 (0.97%)    Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 3/310 (0.97%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Basosquamous Tumor (malignant or  0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 3/310 (0.97%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     3/50 (6%)     |
|      Adenoma, Basosquamous Tumor       2/60 (3%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 6/260 (2.31%)   Mean 2.27%   SD 0.6%      Total 6/310 (1.94%)    Mean 2%      SD 2.53%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         5/50 (10%)    2/50 (4%)     5/50 (10%)          1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|      Carcinoma, Basosq. Tumor (M or    7/60 (12%)    4/50 (8%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 23/260 (8.85%)  Mean 8.73%   SD 2.95%     Total 7/310 (2.26%)    Mean 2.33%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     2/50 (4%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.79%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.33%   SD 0.75%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      3/50 (6%)     1/50 (2%)     4/50 (8%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        5/60 (8%)     2/50 (4%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 15/260 (5.77%)  Mean 5.67%   SD 2.69%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 3/310 (0.97%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.1%      Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Cell Carcinoma, Basosquamous      0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 3/310 (0.97%)    Mean 1%      SD 1.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.1%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/60 (0%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/260 (0.77%)   Mean 0.8%    SD 1.1%      Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)     1/50 (2%)     4/50 (8%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          5/60 (8%)     3/50 (6%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 17/260 (6.54%)  Mean 6.47%   SD 2.66%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)     1/50 (2%)     4/50 (8%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     5/60 (8%)     3/50 (6%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 17/260 (6.54%)  Mean 6.47%   SD 2.66%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/260 (1.15%)   Mean 1.2%    SD 1.1%      Total 2/310 (0.65%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              4/50 (8%)     2/50 (4%)     9/50 (18%)          2/50 (4%)     1/50 (2%)     4/50 (8%)     |
|                                        5/60 (8%)     1/50 (2%)                         3/60 (5%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 21/260 (8.08%)  Mean 8.07%   SD 6.17%     Total 11/310 (3.55%)   Mean 3.5%    SD 2.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      7/50 (14%)    2/50 (4%)    10/50 (20%)          2/50 (4%)     1/50 (2%)     4/50 (8%)     |
|      Myxoma, Myxosarcoma, or Fibrous   5/60 (8%)     2/50 (4%)                         3/60 (5%)     2/50 (4%)     3/50 (6%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 26/260 (10%)    Mean 10.07%  SD 6.91%     Total 15/310 (4.84%)   Mean 4.83%   SD 2.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         3/50 (6%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 4/260 (1.54%)   Mean 1.6%    SD 2.61%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               3/50 (6%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           0/60 (0%)     1/50 (2%)                         0/60 (0%)     2/50 (4%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 5/260 (1.92%)   Mean 2%      SD 2.45%     Total 4/310 (1.29%)    Mean 1.33%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     1/50 (2%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/257 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             41/50 (82%)   48/50 (96%)   45/50 (90%)                                                    |
|                                       55/60 (92%)   49/50 (98%)                                                                  |
| Overall Incidence               Total 238/260 (91.54%)Mean 91.53%  SD 6.23%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/60 (0%)     0/50 (0%)                                                                   |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)     0/48 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/56 (0%)     0/49 (0%)                         0/57 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/251 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)     0/48 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/56 (0%)     0/49 (0%)                         0/57 (0%)     0/48 (0%)     1/48 (2%)     |
| Overall Incidence               Total 0/251 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)     0/48 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/56 (0%)     0/49 (0%)                         0/57 (0%)     0/48 (0%)     1/48 (2%)     |
| Overall Incidence               Total 0/251 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              4/50 (8%)     9/48 (19%)    9/47 (19%)         12/50 (24%)    9/49 (18%)   12/47 (26%)    |
|                                       10/59 (17%)   11/50 (22%)                        9/60 (15%)    6/50 (12%)    2/49 (4%)     |
| Overall Incidence               Total 43/254 (16.93%) Mean 16.97%  SD 5.33%     Total 50/305 (16.39%)  Mean 16.5%   SD 7.98%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)     1/48 (2%)     2/47 (4%)           1/50 (2%)     0/49 (0%)     1/47 (2%)     |
|                                        0/59 (0%)     0/50 (0%)                         1/60 (2%)     0/50 (0%)     1/49 (2%)     |
| Overall Incidence               Total 4/254 (1.57%)   Mean 1.67%   SD 1.77%     Total 4/305 (1.31%)    Mean 1.31%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 5/50 (10%)   10/48 (21%)   11/47 (23%)         13/50 (26%)    9/49 (18%)   13/47 (28%)    |
|                                       10/59 (17%)   11/50 (22%)                       10/60 (17%)    6/50 (12%)    3/49 (6%)     |
| Overall Incidence               Total 47/254 (18.5%)  Mean 18.64%  SD 5.39%     Total 54/305 (17.7%)   Mean 17.8%   SD 8.2%      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/48 (2%)     1/47 (2%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/59 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 2/254 (0.79%)   Mean 0.84%   SD 1.15%     Total 0/305 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/48 (0%)     0/47 (0%)           1/50 (2%)     1/49 (2%)     1/47 (2%)     |
|                                        1/59 (2%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 2/254 (0.79%)   Mean 0.74%   SD 1.02%     Total 4/305 (1.31%)    Mean 1.36%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/48 (2%)     1/47 (2%)           1/50 (2%)     1/49 (2%)     1/47 (2%)     |
|                                        1/59 (2%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 4/254 (1.57%)   Mean 1.58%   SD 0.9%      Total 4/305 (1.31%)    Mean 1.36%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/60 (0%)     0/50 (0%)                         0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/260 (0%)      Mean 0%      SD 0%        Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/258 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/258 (0.39%)   Mean 0.33%   SD 0.75%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/258 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/60 (2%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/258 (0.39%)   Mean 0.33%   SD 0.75%     Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/258 (0%)      Mean 0%      SD 0%        Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 2/310 (0.65%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       14/50 (28%)    8/50 (16%)    9/50 (18%)    |
|                                                                                       11/60 (18%)    6/50 (12%)   11/50 (22%)    |
| Overall Incidence                                                               Total 59/310 (19.03%)  Mean 19.06%  SD 5.47%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    14/50 (28%)    8/50 (16%)   10/50 (20%)    |
|                                                                                       11/60 (18%)    6/50 (12%)   11/50 (22%)    |
| Overall Incidence                                                               Total 60/310 (19.35%)  Mean 19.39%  SD 5.45%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 102
 Version: 04/26/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 19-APR-2004
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/60 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/310 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     0/50 (0%)                         1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/260 (0.38%)   Mean 0.4%    SD 0.89%     Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     2/50 (4%)                         1/60 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/260 (1.15%)   Mean 1.2%    SD 1.79%     Total 1/310 (0.32%)    Mean 0.28%   SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/60 (0%)     2/50 (4%)                         2/60 (3%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/260 (1.54%)   Mean 1.6%    SD 2.19%     Total 2/310 (0.65%)    Mean 0.56%   SD 1.36%     |
 __________________________________________________________________________________________________________________________________
