                                                 Toxicology Data Management System                                     Page: 1
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                    Date of
 Species: RATS                                           Vehicle: CORN OIL                                Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  059602001  09/16/98   9999       0(1)       0  (  0)     N/A      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB|
|BATTELLE COLUMBUS  059600704  06/16/98   9999       0(1)       0  (  0)     N/A      TEF EVALUATION (DIOXIN MIXTURE)            |
|BATTELLE COLUMBUS  059602202  10/14/99   9999       0(1)       0  (  0)     N/A      TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118|
|BATTELLE COLUMBUS  059600701  02/26/98   9999       0(1)       0  (  0)     N/A      TEF EVALUATION (PCB-126)                   |
|BATTELLE COLUMBUS  059600703  06/01/98   9999       0(1)       0  (  0)     N/A      TEF EVALUATION (TCDD)                      |
|BATTELLE COLUMBUS  059600705  04/07/99   9999       0(1)       0  (  0)     N/A      TEF EVALUATION(PECDF (PENTACHLORODIBENZOFUR|
|BATTELLE COLUMBUS  059602101  08/24/98   9999       0(1)       0  (  0)     N/A      TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 15|
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  059602001  09/16/98   729       53(5)      22  (629)    403.6     TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB|
|BATTELLE COLUMBUS  059600704  06/16/98   729       53(5)      16  (616)    381.2     TEF EVALUATION (DIOXIN MIXTURE)            |
|BATTELLE COLUMBUS  059602202  10/14/99   726       53(5)      27  (656)    386.5     TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118|
|BATTELLE COLUMBUS  059600701  02/26/98   727       53(5)      15  (567)    397.1     TEF EVALUATION (PCB-126)                   |
|BATTELLE COLUMBUS  059600703  06/01/98   731       53(5)      25  (637)    382.6     TEF EVALUATION (TCDD)                      |
|BATTELLE COLUMBUS  059600705  04/07/99   728       53(5)      25  (655)    365.7     TEF EVALUATION(PECDF (PENTACHLORODIBENZOFUR|
|BATTELLE COLUMBUS  059602101  08/24/98   731       53(5)      24  (641)    394.5     TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 15|
|________________________________________________________________________________________________________________________________|

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 3
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                         0/0 (0%)      0/0 (0%)      0/0 (0%)          49/53 (92%)   45/53 (85%)   53/53 (100%)   |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)          45/53 (85%)   45/53 (85%)   45/53 (85%)    |
|                                         0/0 (0%)                                      50/53 (94%)                                |
| Overall Incidence                                                               Total 332/371 (89.49%) Mean 89.49%  SD 6.15%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                      0/0 (0%)      0/0 (0%)      0/0 (0%)          14/53 (26%)   18/53 (34%)   16/53 (30%)    |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)          13/53 (25%)   13/53 (25%)   12/53 (23%)    |
|                                         0/0 (0%)                                      12/53 (23%)                                |
| Overall Incidence                                                               Total 98/371 (26.42%)  Mean 26.42%  SD 4.22%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors           0/0 (0%)      0/0 (0%)      0/0 (0%)          51/53 (96%)   51/53 (96%)   53/53 (100%)   |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)          49/53 (92%)   47/53 (89%)   48/53 (91%)    |
|                                         0/0 (0%)                                      52/53 (98%)                                |
| Overall Incidence                                                               Total 351/371 (94.61%) Mean 94.61%  SD 4.14%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                            0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                       0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           2/53 (4%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 3/371 (0.81%)    Mean 0.81%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           2/53 (4%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,     0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|      Mononuclear, or Undifferentiated   0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 3/371 (0.81%)    Mean 0.81%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,      0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     2/53 (4%)     0/53 (0%)     |
|      Lymphocytic, Mixed, NOS, or        0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      Undifferentiated Cell Type         0/0 (0%)                                       2/53 (4%)                                 |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.84%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 4
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                          0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     1/53 (2%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/369 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/52 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/369 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign               0/0 (0%)      0/0 (0%)      0/0 (0%)           3/52 (6%)     5/52 (10%)    3/53 (6%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           8/52 (15%)    3/53 (6%)     4/53 (8%)     |
|                                         0/0 (0%)                                       2/53 (4%)                                 |
| Overall Incidence                                                               Total 28/368 (7.61%)   Mean 7.63%   SD 3.88%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex              0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/368 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant            0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 1/368 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,             0/0 (0%)      0/0 (0%)      0/0 (0%)           3/52 (6%)     5/52 (10%)    3/53 (6%)     |
|      Complex, Malignant, NOS            0/0 (0%)      0/0 (0%)      0/0 (0%)           8/52 (15%)    3/53 (6%)     5/53 (9%)     |
|                                         0/0 (0%)                                       3/53 (6%)                                 |
| Overall Incidence                                                               Total 30/368 (8.15%)   Mean 8.17%   SD 3.66%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 5
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Lipoma                                0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                          0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                 0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           2/53 (4%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Medulloblastoma Mal                   0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant           0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      Astrocytoma                        0/0 (0%)      0/0 (0%)      0/0 (0%)           3/53 (6%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 3/371 (0.81%)    Mean 0.81%   SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/51 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/363 (0.28%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 6
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/51 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/363 (0.28%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor                    0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                       0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/52 (2%)                                 |
| Overall Incidence                                                               Total 1/369 (0.27%)    Mean 0.27%   SD 0.73%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     2/53 (4%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/52 (0%)                                 |
| Overall Incidence                                                               Total 3/369 (0.81%)    Mean 0.81%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyosarcoma                        0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 7
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyosarcoma                        0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     1/52 (2%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     1/51 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 5/367 (1.36%)    Mean 1.36%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/52 (2%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     1/51 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 3/367 (0.82%)    Mean 0.82%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     2/52 (4%)     2/53 (4%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     2/51 (4%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 8/367 (2.18%)    Mean 2.19%   SD 1.73%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/52 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/370 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/52 (2%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/370 (0.27%)    Mean 0.27%   SD 0.73%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     1/52 (2%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 3/370 (0.81%)    Mean 0.81%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                       0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/370 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                                0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/370 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Nephroblastoma                        0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/52 (2%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/370 (0.54%)    Mean 0.54%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                            0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma                0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     2/53 (4%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or           0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     2/53 (4%)     |
|      Hepatocellular Adenoma             0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     2/53 (4%)     |
|      Hepatocellular Adenoma, or         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     1/53 (2%)     |
|      Hepatoblastoma                     0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma          0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/52 (2%)                                 |
| Overall Incidence                                                               Total 2/370 (0.54%)    Mean 0.54%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or     0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      Alveolar/Bronchiolar Adenoma       0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/52 (2%)                                 |
| Overall Incidence                                                               Total 2/370 (0.54%)    Mean 0.54%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                       0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           2/53 (4%)     0/53 (0%)     2/53 (4%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           2/53 (4%)     2/53 (4%)     1/53 (2%)     |
|                                         0/0 (0%)                                       2/53 (4%)                                 |
| Overall Incidence                                                               Total 11/371 (2.96%)   Mean 2.96%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           8/53 (15%)    6/53 (11%)    5/53 (9%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           6/53 (11%)    4/53 (8%)     5/53 (9%)     |
|                                         0/0 (0%)                                       8/53 (15%)                                |
| Overall Incidence                                                               Total 42/371 (11.32%)  Mean 11.32%  SD 2.88%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)          10/53 (19%)    6/53 (11%)    6/53 (11%)    |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           7/53 (13%)    6/53 (11%)    6/53 (11%)    |
|                                         0/0 (0%)                                       9/53 (17%)                                |
| Overall Incidence                                                               Total 50/371 (13.48%)  Mean 13.48%  SD 3.16%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                          0/0 (0%)      0/0 (0%)      0/0 (0%)          40/53 (75%)   34/53 (64%)   42/53 (79%)    |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)          39/53 (74%)   33/53 (62%)   34/53 (64%)    |
|                                         0/0 (0%)                                      41/53 (77%)                                |
| Overall Incidence                                                               Total 263/371 (70.89%) Mean 70.89%  SD 7.13%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma      0/0 (0%)      0/0 (0%)      0/0 (0%)          40/53 (75%)   34/53 (64%)   42/53 (79%)    |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)          40/53 (75%)   35/53 (66%)   35/53 (66%)    |
|                                         0/0 (0%)                                      41/53 (77%)                                |
| Overall Incidence                                                               Total 267/371 (71.97%) Mean 71.97%  SD 6.3%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,     0/0 (0%)      0/0 (0%)      0/0 (0%)          42/53 (79%)   37/53 (70%)   42/53 (79%)    |
|      or Adenoma                         0/0 (0%)      0/0 (0%)      0/0 (0%)          42/53 (79%)   35/53 (66%)   38/53 (72%)    |
|                                         0/0 (0%)                                      43/53 (81%)                                |
| Overall Incidence                                                               Total 279/371 (75.2%)  Mean 75.2%   SD 5.91%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Schwannoma Malignant                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,              0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     1/53 (2%)     |
|      Papilloma Squamous, or Papilloma   0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     1/53 (2%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/53 (0%)     0/52 (0%)     0/53 (0%)     |
|                                                                                        0/52 (0%)     0/51 (0%)     0/53 (0%)     |
|                                                                                        1/53 (2%)                                 |
| Overall Incidence                                                               Total 1/367 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       1/53 (2%)     0/52 (0%)     1/53 (2%)     |
|                                                                                        0/52 (0%)     0/51 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/367 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/53 (2%)     0/52 (0%)     1/53 (2%)     |
|      Malignant, NOS                                                                    0/52 (0%)     0/51 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/367 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/53 (0%)     0/52 (0%)     1/53 (2%)     |
|                                                                                        0/52 (0%)     0/51 (0%)     1/53 (2%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/367 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/51 (2%)     0/51 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/366 (0.27%)    Mean 0.28%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/51 (2%)     0/51 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/366 (0.27%)    Mean 0.28%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/45 (0%)     1/50 (2%)     0/50 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/47 (0%)     0/46 (0%)     0/49 (0%)     |
|                                         0/0 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/336 (0.3%)     Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                        0/0 (0%)      0/0 (0%)      0/0 (0%)          22/53 (42%)   28/53 (53%)   30/53 (57%)    |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)          15/51 (29%)   25/53 (47%)   15/53 (28%)    |
|                                         0/0 (0%)                                      18/53 (34%)                                |
| Overall Incidence                                                               Total 153/369 (41.46%) Mean 41.4%   SD 11.3%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                        0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/51 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/369 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                        0/0 (0%)      0/0 (0%)      0/0 (0%)          23/53 (43%)   28/53 (53%)   30/53 (57%)    |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)          15/51 (29%)   25/53 (47%)   15/53 (28%)    |
|                                         0/0 (0%)                                      18/53 (34%)                                |
| Overall Incidence                                                               Total 154/369 (41.73%) Mean 41.67%  SD 11.32%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/51 (2%)     2/53 (4%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 4/369 (1.08%)    Mean 1.09%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/51 (2%)     2/53 (4%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 4/369 (1.08%)    Mean 1.09%   SD 1.49%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrous Histiocytoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                    0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                 0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|      Basosquamous Tumor Benign          0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous      0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|      Tumor Benign, or                   0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      Trichoepithelioma                  0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      Basosquamous Tumor (malignant or   0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|      NOS)                               0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell      0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|      Adenoma, Basosquamous Tumor        0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|      (benign, malignant or NOS), or     0/0 (0%)                                       0/53 (0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,          0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     2/53 (4%)     |
|      Carcinoma, Basosq. Tumor (M or     0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     1/53 (2%)     0/53 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,   0/0 (0%)                                       0/53 (0%)                                 |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                               Total 4/371 (1.08%)    Mean 1.08%   SD 1.48%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                       0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal        0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      Cell Carcinoma, Basosquamous       0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|      Tumor (malignant or NOS), or       0/0 (0%)                                       0/53 (0%)                                 |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or            0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|      Papilloma                          0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,              0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|      Papilloma, Squamous Cell           0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|      Carcinoma or Keratoacanthoma       0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,              0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|      Papilloma, or Keratoacanthoma      0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           2/53 (4%)     1/53 (2%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 6/371 (1.62%)    Mean 1.62%   SD 1.3%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,       0/0 (0%)      0/0 (0%)      0/0 (0%)           2/53 (4%)     2/53 (4%)     1/53 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous    0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     1/53 (2%)     0/53 (0%)     |
|      Histiocytoma                       0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 7/371 (1.89%)    Mean 1.89%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                          0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,                0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|      Myxosarcoma, or Fibrous            0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      Histiocytoma                       0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma       0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      (malignant or NOS)                 0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,      0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|      or Schwannoma (benign, malignant   0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|      or NOS)                            0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or            0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|      Papilloma Squamous                 0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                        0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/52 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/50 (0%)     0/51 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                               Total 1/360 (0.28%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS       0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/52 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/50 (0%)     0/51 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/48 (0%)                                 |
| Overall Incidence                                                               Total 1/360 (0.28%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)          10/53 (19%)   17/53 (32%)    9/53 (17%)    |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)          15/52 (29%)   20/52 (38%)   13/53 (25%)    |
|                                         0/0 (0%)                                      16/51 (31%)                                |
| Overall Incidence                                                               Total 100/367 (27.25%) Mean 27.3%   SD 7.66%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           4/53 (8%)     2/53 (4%)     4/53 (8%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     1/52 (2%)     2/53 (4%)     |
|                                         0/0 (0%)                                       2/51 (4%)                                 |
| Overall Incidence                                                               Total 15/367 (4.09%)   Mean 4.07%   SD 2.76%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)          13/53 (25%)   18/53 (34%)   13/53 (25%)    |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)          15/52 (29%)   21/52 (40%)   15/53 (28%)    |
|                                         0/0 (0%)                                      18/51 (35%)                                |
| Overall Incidence                                                               Total 113/367 (30.79%) Mean 30.84%  SD 5.93%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                               0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     1/52 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                               Total 1/367 (0.27%)    Mean 0.27%   SD 0.73%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                               Total 1/367 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/52 (0%)     1/52 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/51 (0%)                                 |
| Overall Incidence                                                               Total 2/367 (0.54%)    Mean 0.54%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Fibrosarcoma                          0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Neurofibrosarcoma                     0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       1/53 (2%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma                0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/51 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/367 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           1/53 (2%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/51 (0%)     0/52 (0%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/367 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)     2/53 (4%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/53 (0%)     1/53 (2%)     1/53 (2%)     |
|                                                                                        0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 3/371 (0.81%)    Mean 0.81%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Fibroma                                                                              0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        8/53 (15%)    4/53 (8%)    11/53 (21%)    |
|                                                                                        4/53 (8%)    11/53 (21%)    9/53 (17%)    |
|                                                                                        7/53 (13%)                                |
| Overall Incidence                                                               Total 54/371 (14.56%)  Mean 14.56%  SD 5.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     8/53 (15%)    4/53 (8%)    11/53 (21%)    |
|                                                                                        4/53 (8%)    11/53 (21%)    9/53 (17%)    |
|                                                                                        7/53 (13%)                                |
| Overall Incidence                                                               Total 54/371 (14.56%)  Mean 14.56%  SD 5.52%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/53 (0%)     1/53 (2%)     1/53 (2%)     |
|                                                                                        0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 3/371 (0.81%)    Mean 0.81%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 2/371 (0.54%)    Mean 0.54%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        1/53 (2%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Carcinoma                                                              1/53 (2%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Squamous Cell Papilloma                                                              0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                                                                        0/53 (0%)     0/53 (0%)     1/53 (2%)     |
|                                                                                        0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 05/05/04                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: GAVAGE                                     Date of
 Species: RATS                                           Vehicle: CORN OIL                                 Input File: 5-MAY-2004 
 Strain: SPRAGUE-DAWLEY
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                             0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                  0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     0/53 (0%)     0/53 (0%)     |
|                                         0/0 (0%)      0/0 (0%)      0/0 (0%)           0/53 (0%)     1/53 (2%)     0/53 (0%)     |
|                                         0/0 (0%)                                       0/53 (0%)                                 |
| Overall Incidence                                                               Total 1/371 (0.27%)    Mean 0.27%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
