                                                 Toxicology Data Management System                                     Page: 1
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   730       50(1)      38  (707)     53.4     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058813804  09/14/99   730       50(1)      44  (717)     46.0     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   727      100(1)      91  (707)     49.6     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   729       50(1)      40  (703)     53.9     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   730       50(1)      39  (702)     52.5     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   729       49(1)      35  (704)     50.6     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   733       50(1)      40  (705)     46.9     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   727       50(1)      39  (708)     51.4     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   728      100(1)      91  (705)     46.5     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   726       50(1)      37  (710)     53.4     TRIETHANOLAMINE                            |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  055021503  03/04/97   729       50(5)      39  (709)     62.7     ACRYLONITRILE                              |
|BATTELLE COLUMBUS  058813804  09/14/99   729       50(5)      40  (706)     46.2     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634804  06/19/96   733       99(5)      81  (695)     48.0     CITRAL                                     |
|BATTELLE COLUMBUS  058803106  03/19/97   728       50(5)      37  (699)     61.4     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812207  07/01/97   729       50(5)      37  (692)     62.9     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805006  10/16/95   731       50(5)      35  (700)     58.1     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812004  01/04/96   734       50(5)      42  (717)     46.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800706  08/02/95   728       50(5)      40  (702)     58.8     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611104  09/24/97   733      100(5)      84  (711)     46.0     TRANS-CINNAMALDEHYDE                       |
|BATTELLE COLUMBUS  050510914  09/24/98   729       50(1)      35  (692)     62.7     TRIETHANOLAMINE                            |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   733       50( )      40  (701)     54.1     DECALIN                                    |
|BATTELLE NORTHWEST 058800406  09/27/99   729       50( )      41  (702)     52.2     DIVINYLBENZENE                             |
|BATTELLE NORTHWEST 058812404  01/25/96   733       50( )      37  (711)     51.6     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   729       50( )      35  (703)     54.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   729       50( )      34  (690)     53.0     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   729       50( )      39  (710)     55.4     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302606  08/28/97   735       49( )      37  (708)     61.5     DECALIN                                    |
|BATTELLE NORTHWEST 058800406  09/27/99   731       50( )      33  (681)     63.0     DIVINYLBENZENE                             |
|BATTELLE NORTHWEST 058812404  01/25/96   735       50( )      42  (713)     54.8     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 059000406  09/29/97   731       50( )      39  (718)     59.8     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600106  12/21/98   731       50( )      36  (702)     54.6     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142708  01/13/97   731       50( )      38  (692)     58.7     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE TOXICOLOGY059700602T 06/05/00   729       50( )      40  (709)     53.2     METHYL ISOBUTYL KETONE                     |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE TOXICOLOGY059700602T 06/05/00   731       50( )      35  (695)     60.3     METHYL ISOBUTYL KETONE                     |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902906  10/05/94   734      100(1)      76  (711)     53.4     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902906  10/05/94   735      100(5)      70  (702)     59.7     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                            Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302307  07/25/97   729       50(1)      44  (721)     57.3     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   729       50(1)      43  (706)     46.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059201306  02/03/00   729       50(1)      45  (717)     46.1     4-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601004  09/30/98   729       50(1)      38  (694)     54.1     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  059302008  05/08/00   729       50(1)      39  (710)     52.6     DIISOPROPYLCARBODIIMIDE                    |
|SOUTHERN RESEARCH  050520309  02/20/96   729       60(1)      52  (712)     48.0     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   729       50(1)      46  (722)     47.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   729       50(1)      39  (696)     51.4     RIDDELLIINE                                |
|SOUTHERN RESEARCH  059601804  12/15/98   9999       0(5)       0  (  0)     N/A      BROMODICHLOROMETHANE                       |
|SOUTHERN RESEARCH  059601706  02/23/00   729       49(1)      31  (685)     52.5     DIBROMOACETIC ACID                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302307  07/25/97   732       50(5)      42  (717)     64.2     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201206  07/29/98   732       50(5)      46  (720)     38.8     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059201306  02/03/00   734       50(5)      42  (706)     45.6     4-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601004  09/30/98   735       50(5)      36  (691)     66.5     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  059302008  05/08/00   732       50(1)      33  (674)     65.7     DIISOPROPYLCARBODIIMIDE                    |
|SOUTHERN RESEARCH  050520309  02/20/96   731       60(5)      52  (708)     46.6     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520508  11/14/95   732       50(5)      46  (727)     41.4     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516106  03/20/96   735       50(5)      34  (674)     59.5     RIDDELLIINE                                |
|SOUTHERN RESEARCH  059601804  12/15/98   729       50(5)      36  (699)     66.6     BROMODICHLOROMETHANE                       |
|SOUTHERN RESEARCH  059601706  02/23/00   734       50(5)      38  (708)     64.3     DIBROMOACETIC ACID                         |
|________________________________________________________________________________________________________________________________|

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 7
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       34/50 (68%)   27/50 (54%)   40/100(40%)         29/50 (58%)   15/50 (30%)   28/99 (28%)    |
|                                       27/50 (54%)   29/50 (58%)   29/49 (59%)         22/50 (44%)   17/50 (34%)   24/50 (48%)    |
|                                       16/50 (32%)   28/50 (56%)   37/100(37%)         15/50 (30%)   13/50 (26%)   32/100(32%)    |
|                                       30/50 (60%)                                     24/50 (48%)                                |
| Overall Incidence               Total 297/599 (49.58%)Mean 51.82%  SD 11.55%    Total 219/599 (36.56%) Mean 37.83%  SD 10.82%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)   17/50 (34%)   32/100(32%)         24/50 (48%)   16/50 (32%)   24/99 (24%)    |
|                                       19/50 (38%)   24/50 (48%)   24/49 (49%)         18/50 (36%)   17/50 (34%)   20/50 (40%)    |
|                                       21/50 (42%)   27/50 (54%)   28/100(28%)         12/50 (24%)   12/50 (24%)   46/100(46%)    |
|                                       28/50 (56%)                                     27/50 (54%)                                |
| Overall Incidence               Total 249/599 (41.57%)Mean 43.9%   SD 10.65%    Total 216/599 (36.06%) Mean 36.22%  SD 10.7%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   38/50 (76%)   55/100(55%)         39/50 (78%)   25/50 (50%)   45/99 (45%)    |
|                                       39/50 (78%)   38/50 (76%)   40/49 (82%)         32/50 (64%)   29/50 (58%)   34/50 (68%)    |
|                                       32/50 (64%)   40/50 (80%)   57/100(57%)         23/50 (46%)   21/50 (42%)   62/100(62%)    |
|                                       45/50 (90%)                                     38/50 (76%)                                |
| Overall Incidence               Total 429/599 (71.62%)Mean 74.76%  SD 12.36%    Total 348/599 (58.1%)  Mean 58.95%  SD 12.86%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     4/100(4%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 10/599 (1.67%)  Mean 1.5%    SD 1.72%     Total 10/599 (1.67%)   Mean 1.5%    SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)     3/50 (6%)     3/100(3%)           4/50 (8%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     6/50 (12%)    3/49 (6%)           3/50 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        3/50 (6%)     7/50 (14%)    2/100(2%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        3/50 (6%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 33/599 (5.51%)  Mean 6.11%   SD 4.23%     Total 16/599 (2.67%)   Mean 3.1%    SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    3/50 (6%)     5/100(5%)           4/50 (8%)     1/50 (2%)     1/99 (1%)     |
|                                        2/50 (4%)     6/50 (12%)    3/49 (6%)           5/50 (10%)    1/50 (2%)     4/50 (8%)     |
|                                        3/50 (6%)     7/50 (14%)    5/100(5%)           0/50 (0%)     1/50 (2%)     5/100(5%)     |
|                                        4/50 (8%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 43/599 (7.18%)  Mean 7.61%   SD 3.33%     Total 26/599 (4.34%)   Mean 4.6%    SD 3.63%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.4%    SD 0.84%     Total 7/599 (1.17%)    Mean 1.2%    SD 2.53%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     2/50 (4%)     4/100(4%)           4/50 (8%)     8/50 (16%)    7/99 (7%)     |
|      Lymphocytic, Mixed, NOS, or       1/50 (2%)     3/50 (6%)     2/49 (4%)           5/50 (10%)    7/50 (14%)    9/50 (18%)    |
|      Undifferentiated Cell Type        3/50 (6%)     1/50 (2%)     8/100(8%)           6/50 (12%)    7/50 (14%)   23/100(23%)    |
|                                        0/50 (0%)                                       8/50 (16%)                                |
| Overall Incidence               Total 27/599 (4.51%)  Mean 4.21%   SD 2.39%     Total 84/599 (14.02%)  Mean 13.81%  SD 4.81%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      NOS                               1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.9%    SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.9%    SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/50 (6%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     5/49 (10%)          0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     2/99 (2%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 17/597 (2.85%)  Mean 3.02%   SD 3.48%     Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/597 (0%)      Mean 0%      SD 0%        Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/597 (0%)      Mean 0%      SD 0%        Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.63%     Total 2/595 (0.34%)    Mean 0.4%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/596 (0%)      Mean 0%      SD 0%        Total 3/595 (0.5%)     Mean 0.4%    SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     1/50 (2%)     1/99 (1%)     |
|      Complex, Malignant, NOS           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/99 (0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/595 (0.84%)    Mean 0.81%   SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      2/50 (4%)     0/49 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/598 (1%)      Mean 1.2%    SD 1.93%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/49 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/598 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/49 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/598 (0.33%)   Mean 0.3%    SD 0.67%     Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 3/599 (0.5%)     Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 3/599 (0.5%)     Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.2%    SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.2%    SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/50 (0%)     0/45 (0%)     0/100(0%)           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/48 (0%)     0/100(0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/576 (0%)      Mean 0%      SD 0%        Total 0/582 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/50 (0%)     0/45 (0%)     0/100(0%)           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                        0/48 (0%)     0/40 (0%)     0/46 (0%)           0/50 (0%)     0/39 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/48 (0%)     0/100(0%)     |
|                                        0/48 (0%)                                       0/48 (0%)                                 |
| Overall Incidence               Total 0/576 (0%)      Mean 0%      SD 0%        Total 0/582 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)    6/50 (12%)    4/100(4%)          10/50 (20%)    1/50 (2%)     3/99 (3%)     |
|                                        2/50 (4%)     6/50 (12%)    3/49 (6%)           1/50 (2%)     4/50 (8%)     2/50 (4%)     |
|                                        5/50 (10%)    4/50 (8%)     8/100(8%)           3/50 (6%)     0/50 (0%)     2/100(2%)     |
|                                        7/50 (14%)                                      5/50 (10%)                                |
| Overall Incidence               Total 50/599 (8.35%)  Mean 8.81%   SD 3.41%     Total 31/599 (5.18%)   Mean 5.7%    SD 5.89%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/100(0%)           1/50 (2%)     0/50 (0%)     1/99 (1%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.6%    SD 0.97%     Total 7/599 (1.17%)    Mean 1.2%    SD 1.62%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 6/50 (12%)    7/50 (14%)    4/100(4%)          11/50 (22%)    1/50 (2%)     4/99 (4%)     |
|                                        3/50 (6%)     6/50 (12%)    3/49 (6%)           1/50 (2%)     4/50 (8%)     4/50 (8%)     |
|                                        5/50 (10%)    4/50 (8%)     8/100(8%)           3/50 (6%)     0/50 (0%)     3/100(3%)     |
|                                        7/50 (14%)                                      7/50 (14%)                                |
| Overall Incidence               Total 53/599 (8.85%)  Mean 9.41%   SD 3.52%     Total 38/599 (6.34%)   Mean 6.9%    SD 6.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/598 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/598 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/598 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/598 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 3/599 (0.5%)     Mean 0.6%    SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.41%   SD 1.29%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 7/599 (1.17%)   Mean 1.1%    SD 1.37%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 20/599 (3.34%)  Mean 3.6%    SD 3.4%      Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.41%   SD 1.29%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 20/599 (3.34%)  Mean 3.6%    SD 3.4%      Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     3/100(3%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     4/50 (8%)     3/49 (6%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     5/50 (10%)    1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 22/599 (3.67%)  Mean 4.01%   SD 3.44%     Total 3/599 (0.5%)     Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    1/50 (2%)     0/50 (0%)     2/100(2%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.3%    SD 1.64%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           2/50 (4%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.51%   SD 2.28%     Total 2/595 (0.34%)    Mean 0.4%    SD 1.26%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/595 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/49 (4%)           2/50 (4%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     3/50 (6%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.51%   SD 2.28%     Total 3/595 (0.5%)     Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.6%    SD 0.97%     Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.6%    SD 0.97%     Total 0/597 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/48 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/597 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 2/598 (0.33%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)     0/50 (0%)     2/100(2%)           2/50 (4%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/49 (2%)           2/50 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 12/599 (2%)     Mean 2.2%    SD 1.75%     Total 5/598 (0.84%)    Mean 1%      SD 1.7%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     5/50 (10%)    0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.6%    SD 3.1%      Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)   11/50 (22%)   20/100(20%)         14/50 (28%)    5/50 (10%)    8/99 (8%)     |
|                                       17/50 (34%)   19/50 (38%)   17/49 (35%)         11/50 (22%)    7/50 (14%)    9/50 (18%)    |
|                                        6/50 (12%)   19/50 (38%)   14/100(14%)          4/50 (8%)     9/50 (18%)    7/99 (7%)     |
|                                       19/50 (38%)                                      9/50 (18%)                                |
| Overall Incidence               Total 165/599 (27.55%)Mean 29.67%  SD 11.69%    Total 83/598 (13.88%)  Mean 15.12%  SD 6.92%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            14/50 (28%)    8/50 (16%)   13/100(13%)          7/50 (14%)    0/50 (0%)     4/99 (4%)     |
|                                       14/50 (28%)   11/50 (22%)   13/49 (27%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|                                        9/50 (18%)    9/50 (18%)   13/100(13%)          3/50 (6%)     2/50 (4%)     3/99 (3%)     |
|                                       17/50 (34%)                                      6/50 (12%)                                |
| Overall Incidence               Total 121/599 (20.2%) Mean 21.65%  SD 7.19%     Total 37/598 (6.19%)   Mean 6.71%   SD 4.9%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         14/50 (28%)    8/50 (16%)   13/100(13%)          7/50 (14%)    0/50 (0%)     4/99 (4%)     |
|      Hepatoblastoma                   14/50 (28%)   12/50 (24%)   14/49 (29%)          7/50 (14%)    3/50 (6%)     2/50 (4%)     |
|                                        9/50 (18%)   12/50 (24%)   13/100(13%)          3/50 (6%)     2/50 (4%)     3/99 (3%)     |
|                                       18/50 (36%)                                      6/50 (12%)                                |
| Overall Incidence               Total 127/599 (21.2%) Mean 22.86%  SD 7.64%     Total 37/598 (6.19%)   Mean 6.71%   SD 4.9%      |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         32/50 (64%)   18/50 (36%)   28/100(28%)         20/50 (40%)    5/50 (10%)   12/99 (12%)    |
|      Hepatocellular Adenoma           29/50 (58%)   23/50 (46%)   24/49 (49%)         17/50 (34%)   10/50 (20%)   10/50 (20%)    |
|                                       15/50 (30%)   24/50 (48%)   26/100(26%)          6/50 (12%)   10/50 (20%)    9/99 (9%)     |
|                                       33/50 (66%)                                     12/50 (24%)                                |
| Overall Incidence               Total 252/599 (42.07%)Mean 45.1%   SD 14.73%    Total 111/598 (18.56%) Mean 20.12%  SD 10.31%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           32/50 (64%)   18/50 (36%)   28/100(28%)         20/50 (40%)    5/50 (10%)   12/99 (12%)    |
|      Hepatocellular Adenoma, or       29/50 (58%)   24/50 (48%)   24/49 (49%)         17/50 (34%)   10/50 (20%)   10/50 (20%)    |
|      Hepatoblastoma                   15/50 (30%)   26/50 (52%)   26/100(26%)          6/50 (12%)   10/50 (20%)    9/99 (9%)     |
|                                       33/50 (66%)                                     12/50 (24%)                                |
| Overall Incidence               Total 255/599 (42.57%)Mean 45.7%   SD 14.89%    Total 111/598 (18.56%) Mean 20.12%  SD 10.31%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.65%     Total 1/598 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        10/50 (20%)   14/50 (28%)   12/100(12%)          4/50 (8%)     0/50 (0%)     5/99 (5%)     |
|                                        3/50 (6%)    10/50 (20%)    2/49 (4%)           2/50 (4%)     2/50 (4%)     6/50 (12%)    |
|                                        6/50 (12%)   10/50 (20%)    9/100(9%)           0/50 (0%)     1/50 (2%)     3/100(3%)     |
|                                        6/50 (12%)                                      3/50 (6%)                                 |
| Overall Incidence               Total 82/599 (13.69%) Mean 14.31%  SD 7.47%     Total 26/599 (4.34%)   Mean 4.41%   SD 3.66%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       4/50 (8%)     2/50 (4%)     9/100(9%)           2/50 (4%)     1/50 (2%)     6/99 (6%)     |
|                                        3/50 (6%)     5/50 (10%)    4/49 (8%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        7/50 (14%)    4/50 (8%)     7/100(7%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        7/50 (14%)                                      2/50 (4%)                                 |
| Overall Incidence               Total 52/599 (8.68%)  Mean 8.82%   SD 3.19%     Total 17/599 (2.84%)   Mean 2.61%   SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)   16/50 (32%)   20/100(20%)          6/50 (12%)    1/50 (2%)    11/99 (11%)    |
|      Alveolar/Bronchiolar Adenoma      6/50 (12%)   14/50 (28%)    6/49 (12%)          3/50 (6%)     3/50 (6%)     6/50 (12%)    |
|                                       13/50 (26%)   13/50 (26%)   14/100(14%)          0/50 (0%)     1/50 (2%)     5/100(5%)     |
|                                       12/50 (24%)                                      5/50 (10%)                                |
| Overall Incidence               Total 128/599 (21.37%)Mean 22.22%  SD 7.23%     Total 41/599 (6.84%)   Mean 6.61%   SD 4.46%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           2/50 (4%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.4%    SD 1.26%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 3/599 (0.5%)     Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 3/599 (0.5%)     Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/595 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/595 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/96 (0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/595 (0%)      Mean 0%      SD 0%        Total 0/598 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 3/599 (0.5%)     Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          8/50 (16%)    1/49 (2%)     3/99 (3%)     |
|                                                                                        0/50 (0%)     1/47 (2%)     2/50 (4%)     |
|                                                                                        2/50 (4%)     0/47 (0%)     2/100(2%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 20/592 (3.38%)   Mean 3.52%   SD 4.59%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 4/592 (0.68%)    Mean 0.6%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 4/592 (0.68%)    Mean 0.6%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/592 (0.51%)    Mean 0.5%    SD 1.27%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/592 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/49 (0%)     1/99 (1%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     2/100(2%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 4/592 (0.68%)    Mean 0.5%    SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/592 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/50 (0%)     0/49 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/592 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     1/49 (2%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/47 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/592 (0.17%)    Mean 0.2%    SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/598 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/595 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/46 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/598 (0%)      Mean 0%      SD 0%        Total 0/595 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           2/48 (4%)     2/50 (4%)     8/97 (8%)     |
|   Adenoma                              0/49 (0%)     0/47 (0%)     0/48 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           3/48 (6%)     1/48 (2%)    11/97 (11%)    |
|                                        0/50 (0%)                                       8/50 (16%)                                |
| Overall Incidence               Total 0/585 (0%)      Mean 0%      SD 0%        Total 40/584 (6.85%)   Mean 6.24%   SD 4.45%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     0/97 (0%)     |
|   Carcinoma                            0/49 (0%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           0/48 (0%)     0/48 (0%)     0/97 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/585 (0%)      Mean 0%      SD 0%        Total 0/584 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/49 (0%)     0/48 (0%)     0/98 (0%)           2/48 (4%)     2/50 (4%)     8/97 (8%)     |
|   Carcinoma or Adenoma                 0/49 (0%)     0/47 (0%)     0/48 (0%)           1/49 (2%)     2/48 (4%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     0/98 (0%)           3/48 (6%)     1/48 (2%)    11/97 (11%)    |
|                                        0/50 (0%)                                       8/50 (16%)                                |
| Overall Incidence               Total 0/585 (0%)      Mean 0%      SD 0%        Total 40/584 (6.85%)   Mean 6.24%   SD 4.45%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              1/49 (2%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     2/97 (2%)     |
|                                        1/49 (2%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     1/98 (1%)           1/48 (2%)     0/48 (0%)     0/97 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/585 (0.68%)   Mean 0.71%   SD 0.96%     Total 5/584 (0.86%)    Mean 0.82%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 1/49 (2%)     0/48 (0%)     0/98 (0%)           0/48 (0%)     0/50 (0%)     2/97 (2%)     |
|                                        1/49 (2%)     0/47 (0%)     0/48 (0%)           0/49 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/49 (0%)     0/49 (0%)     1/98 (1%)           1/48 (2%)     0/48 (0%)     0/97 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/585 (0.68%)   Mean 0.71%   SD 0.96%     Total 5/584 (0.86%)    Mean 0.82%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.65%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/590 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/98 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/590 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%                                                      |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 3/599 (0.5%)     Mean 0.5%    SD 1.27%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|      Trichoepithelioma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|      Papilloma, Sq Papilloma,          0/50 (0%)                                       0/50 (0%)                                 |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.3%    SD 0.69%     Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/100(2%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.3%    SD 0.67%     Total 2/599 (0.33%)    Mean 0.2%    SD 0.42%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.4%    SD 0.84%     Total 3/599 (0.5%)     Mean 0.6%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|      Carcinoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.3%    SD 0.69%     Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.3%    SD 0.69%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     0/50 (0%)     1/100(1%)           3/50 (6%)     1/50 (2%)     2/99 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     4/100(4%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 21/599 (3.51%)   Mean 3.6%    SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     1/100(1%)           2/50 (4%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     4/100(4%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 10/599 (1.67%)   Mean 1.6%    SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     0/50 (0%)     1/100(1%)           3/50 (6%)     1/50 (2%)     2/99 (2%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     2/50 (4%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     1/50 (2%)     4/100(4%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%     Total 21/599 (3.51%)   Mean 3.6%    SD 1.84%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.8%    SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.8%    SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     2/99 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           3/50 (6%)     3/50 (6%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 10/599 (1.67%)   Mean 1.8%    SD 2.39%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     2/100(2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 5/599 (0.83%)    Mean 0.8%    SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/597 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/591 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/49 (2%)           1/50 (2%)     0/47 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     1/100(1%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        2/49 (4%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 10/597 (1.68%)  Mean 1.91%   SD 1.92%     Total 3/591 (0.51%)    Mean 0.6%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     1/100(1%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/597 (0.17%)   Mean 0.1%    SD 0.32%     Total 0/591 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/47 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/49 (0%)     0/49 (0%)     0/97 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/597 (0%)      Mean 0%      SD 0%        Total 0/591 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.2%    SD 0.63%     Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           3/50 (6%)     1/50 (2%)     0/100(0%)           3/50 (6%)     2/50 (4%)     1/99 (1%)     |
|      Papilloma Squamous                1/50 (2%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 8/599 (1.34%)   Mean 1.6%    SD 1.84%     Total 12/599 (2%)      Mean 2.2%    SD 2.15%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              3/50 (6%)     1/50 (2%)     0/100(0%)           3/50 (6%)     1/50 (2%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     1/50 (2%)     1/100(1%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 7/599 (1.17%)   Mean 1.4%    SD 1.9%      Total 11/599 (1.84%)   Mean 2%      SD 2.05%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        3/50 (6%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 6/599 (1%)      Mean 1%      SD 1.89%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/599 (0.17%)   Mean 0.1%    SD 0.32%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/100(1%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 2/599 (0.33%)   Mean 0.3%    SD 0.67%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           1/49 (2%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     0/46 (0%)     0/93 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/535 (0%)      Mean 0%      SD 0%        Total 1/567 (0.18%)    Mean 0.2%    SD 0.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     1/46 (2%)     0/93 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/535 (0%)      Mean 0%      SD 0%        Total 1/567 (0.18%)    Mean 0.22%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     0/46 (0%)     0/93 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/535 (0%)      Mean 0%      SD 0%        Total 0/567 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/47 (0%)     0/46 (0%)     0/99 (0%)           0/50 (0%)     0/46 (0%)     0/95 (0%)     |
|                                        0/46 (0%)     0/40 (0%)     0/40 (0%)           0/49 (0%)     0/43 (0%)     0/47 (0%)     |
|                                        0/45 (0%)     0/37 (0%)     0/87 (0%)           0/49 (0%)     1/46 (2%)     0/93 (0%)     |
|                                        0/48 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/535 (0%)      Mean 0%      SD 0%        Total 1/567 (0.18%)    Mean 0.22%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/596 (0%)      Mean 0%      SD 0%        Total 0/588 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/588 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.65%     Total 0/588 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/50 (2%)     1/100(1%)           2/50 (4%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/49 (0%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)           2/50 (4%)     0/49 (0%)     1/98 (1%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/596 (0.84%)   Mean 0.8%    SD 0.92%     Total 5/588 (0.85%)    Mean 0.9%    SD 1.66%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/99 (0%)           0/50 (0%)     0/49 (0%)     0/98 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/596 (0.17%)   Mean 0.2%    SD 0.65%     Total 1/588 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     1/100(1%)           2/50 (4%)     0/50 (0%)     0/97 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     1/49 (2%)           0/49 (0%)     0/46 (0%)     0/49 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/99 (1%)           2/50 (4%)     0/49 (0%)     1/98 (1%)     |
|                                        1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 6/596 (1.01%)   Mean 1.01%   SD 0.95%     Total 6/588 (1.02%)    Mean 1.1%    SD 1.66%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.68%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     1/99 (1%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 2/599 (0.33%)    Mean 0.3%    SD 0.68%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     1/50 (2%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/599 (0.5%)    Mean 0.6%    SD 0.97%     Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/592 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/592 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/592 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/592 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/43 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/592 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/599 (0.17%)    Mean 0.1%    SD 0.32%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/100(1%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/599 (0.33%)    Mean 0.3%    SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     4/50 (8%)     2/99 (2%)     |
|                                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 12/599 (2%)      Mean 2.1%    SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/50 (2%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     5/50 (10%)    2/99 (2%)     |
|                                                                                        0/50 (0%)     3/50 (6%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     1/100(1%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 13/599 (2.17%)   Mean 2.3%    SD 3.27%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 0/599 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/100(0%)           1/50 (2%)     0/50 (0%)     0/99 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/100(0%)           0/50 (0%)     0/50 (0%)     0/100(0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/599 (0%)      Mean 0%      SD 0%        Total 1/599 (0.17%)    Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 43
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       32/50 (64%)   35/50 (70%)   29/50 (58%)         28/49 (57%)   28/50 (56%)   25/50 (50%)    |
|                                       30/50 (60%)   32/50 (64%)   31/50 (62%)         25/50 (50%)   27/50 (54%)   19/50 (38%)    |
| Overall Incidence               Total 189/300 (63%)   Mean 63%     SD 4.15%     Total 152/299 (50.84%) Mean 50.86%  SD 6.97%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   26/50 (52%)   21/50 (42%)         22/49 (45%)   22/50 (44%)   20/50 (40%)    |
|                                       22/50 (44%)   23/50 (46%)   27/50 (54%)         23/50 (46%)   19/50 (38%)   17/50 (34%)    |
| Overall Incidence               Total 142/300 (47.33%)Mean 47.33%  SD 4.68%     Total 123/299 (41.14%) Mean 41.15%  SD 4.65%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         43/50 (86%)   43/50 (86%)   41/50 (82%)         39/49 (80%)   40/50 (80%)   35/50 (70%)    |
|                                       41/50 (82%)   42/50 (84%)   42/50 (84%)         37/50 (74%)   39/50 (78%)   32/50 (64%)    |
| Overall Incidence               Total 252/300 (84%)   Mean 84%     SD 1.79%     Total 222/299 (74.25%) Mean 74.27%  SD 6.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 4/299 (1.34%)    Mean 1.34%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      1/50 (2%)     6/50 (12%)    3/50 (6%)           1/49 (2%)     1/50 (2%)     3/50 (6%)     |
|                                        3/50 (6%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 15/300 (5%)     Mean 5%      SD 3.95%     Total 9/299 (3.01%)    Mean 3.01%   SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)     6/50 (12%)    3/50 (6%)           2/49 (4%)     2/50 (4%)     4/50 (8%)     |
|                                        4/50 (8%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 17/300 (5.67%)  Mean 5.67%   SD 3.88%     Total 13/299 (4.35%)   Mean 4.35%   SD 1.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 8/299 (2.68%)    Mean 2.67%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     3/50 (6%)     1/50 (2%)     1/50 (2%)          11/49 (22%)   11/50 (22%)    8/50 (16%)    |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)     3/50 (6%)     2/50 (4%)          13/50 (26%)    5/50 (10%)    7/50 (14%)    |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence               Total 13/300 (4.33%)  Mean 4.33%   SD 1.97%     Total 55/299 (18.39%)  Mean 18.41%  SD 6.05%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/49 (4%)     3/49 (6%)     2/50 (4%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     4/49 (8%)     1/50 (2%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 13/295 (4.41%)  Mean 4.41%   SD 2.39%     Total 2/298 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     2/49 (4%)     0/50 (0%)           2/48 (4%)     0/49 (0%)     2/49 (4%)     |
|                                        0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     1/49 (2%)     2/49 (4%)     |
| Overall Incidence               Total 2/293 (0.68%)   Mean 0.68%   SD 1.67%     Total 7/291 (2.41%)    Mean 2.4%    SD 2.02%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     1/49 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/293 (0%)      Mean 0%      SD 0%        Total 1/291 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     2/49 (4%)     0/50 (0%)           2/48 (4%)     0/49 (0%)     2/49 (4%)     |
|      Complex, Malignant, NOS           0/47 (0%)     0/48 (0%)     0/50 (0%)           0/47 (0%)     2/49 (4%)     2/49 (4%)     |
| Overall Incidence               Total 2/293 (0.68%)   Mean 0.68%   SD 1.67%     Total 8/291 (2.75%)    Mean 2.74%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      1/49 (2%)     2/50 (4%)     1/49 (2%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
| Overall Incidence               Total 4/296 (1.35%)   Mean 1.35%   SD 1.64%     Total 2/296 (0.68%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/49 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/296 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/49 (0%)     1/50 (2%)     0/49 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/296 (0.34%)   Mean 0.33%   SD 0.82%     Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/42 (0%)     1/42 (2%)     0/43 (0%)           0/41 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/42 (0%)           0/40 (0%)     0/40 (0%)     0/46 (0%)     |
| Overall Incidence               Total 1/246 (0.41%)   Mean 0.4%    SD 0.97%     Total 0/258 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/42 (0%)     0/42 (0%)     0/43 (0%)           0/41 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/38 (0%)     0/39 (0%)     0/42 (0%)           0/40 (0%)     0/40 (0%)     0/46 (0%)     |
| Overall Incidence               Total 0/246 (0%)      Mean 0%      SD 0%        Total 0/258 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              6/50 (12%)    5/50 (10%)    1/50 (2%)           3/49 (6%)     4/50 (8%)     3/50 (6%)     |
|                                        6/50 (12%)    7/50 (14%)    8/50 (16%)          3/50 (6%)     4/50 (8%)     2/50 (4%)     |
| Overall Incidence               Total 33/300 (11%)    Mean 11%     SD 4.86%     Total 19/299 (6.35%)   Mean 6.35%   SD 1.5%      |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            3/50 (6%)     1/50 (2%)     0/50 (0%)           1/49 (2%)     2/50 (4%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.67%   SD 2.34%     Total 4/299 (1.34%)    Mean 1.34%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)    6/50 (12%)    1/50 (2%)           4/49 (8%)     6/50 (12%)    3/50 (6%)     |
|                                        7/50 (14%)    7/50 (14%)    8/50 (16%)          3/50 (6%)     5/50 (10%)    2/50 (4%)     |
| Overall Incidence               Total 38/300 (12.67%) Mean 12.67%  SD 5.61%     Total 23/299 (7.69%)   Mean 7.69%   SD 2.95%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/300 (1%)      Mean 1%      SD 1.67%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    1/50 (2%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     3/50 (6%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.67%   SD 2.66%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     3/50 (6%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/300 (2%)      Mean 2%      SD 2.53%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     3/50 (6%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 7/300 (2.33%)   Mean 2.33%   SD 2.34%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)     1/49 (2%)     3/50 (6%)           1/49 (2%)     0/48 (0%)     0/50 (0%)     |
|                                        2/48 (4%)     0/48 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 8/294 (2.72%)   Mean 2.71%   SD 2.08%     Total 3/295 (1.02%)    Mean 1.02%   SD 1.12%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     1/48 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 1/295 (0.34%)    Mean 0.35%   SD 0.85%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)     1/49 (2%)     3/50 (6%)           1/49 (2%)     1/48 (2%)     0/50 (0%)     |
|                                        2/48 (4%)     0/48 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 8/294 (2.72%)   Mean 2.71%   SD 2.08%     Total 4/295 (1.36%)    Mean 1.37%   SD 1.06%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/299 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/49 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/299 (0.67%)   Mean 0.67%   SD 1.03%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/49 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/299 (1%)      Mean 1%      SD 1.67%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     3/50 (6%)     2/50 (4%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/300 (3%)      Mean 3%      SD 2.1%      Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              22/50 (44%)   22/50 (44%)   17/50 (34%)          7/49 (14%)   17/49 (35%)   12/50 (24%)    |
|                                       18/50 (36%)   23/50 (46%)   15/50 (30%)         14/49 (29%)    9/50 (18%)    6/50 (12%)    |
| Overall Incidence               Total 117/300 (39%)   Mean 39%     SD 6.54%     Total 65/297 (21.89%)  Mean 21.93%  SD 8.76%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            10/50 (20%)   13/50 (26%)   11/50 (22%)          4/49 (8%)     5/49 (10%)    6/50 (12%)    |
|                                        9/50 (18%)   16/50 (32%)   14/50 (28%)          4/49 (8%)     6/50 (12%)    6/50 (12%)    |
| Overall Incidence               Total 73/300 (24.33%) Mean 24.33%  SD 5.28%     Total 31/297 (10.44%)  Mean 10.42%  SD 1.88%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)   13/50 (26%)   11/50 (22%)          4/49 (8%)     5/49 (10%)    6/50 (12%)    |
|      Hepatoblastoma                    9/50 (18%)   16/50 (32%)   14/50 (28%)          4/49 (8%)     6/50 (12%)    6/50 (12%)    |
| Overall Incidence               Total 73/300 (24.33%) Mean 24.33%  SD 5.28%     Total 31/297 (10.44%)  Mean 10.42%  SD 1.88%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         28/50 (56%)   30/50 (60%)   26/50 (52%)         11/49 (22%)   19/49 (39%)   18/50 (36%)    |
|      Hepatocellular Adenoma           25/50 (50%)   34/50 (68%)   26/50 (52%)         18/49 (37%)   13/50 (26%)   12/50 (24%)    |
| Overall Incidence               Total 169/300 (56.33%)Mean 56.33%  SD 6.74%     Total 91/297 (30.64%)  Mean 30.66%  SD 7.28%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           28/50 (56%)   30/50 (60%)   26/50 (52%)         11/49 (22%)   19/49 (39%)   18/50 (36%)    |
|      Hepatocellular Adenoma, or       25/50 (50%)   34/50 (68%)   26/50 (52%)         18/49 (37%)   13/50 (26%)   12/50 (24%)    |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence               Total 169/300 (56.33%)Mean 56.33%  SD 6.74%     Total 91/297 (30.64%)  Mean 30.66%  SD 7.28%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/297 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         8/50 (16%)   12/49 (24%)   13/50 (26%)          1/49 (2%)     4/50 (8%)     3/50 (6%)     |
|                                       13/50 (26%)    6/50 (12%)   13/50 (26%)          2/50 (4%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 65/299 (21.74%) Mean 21.75%  SD 6.16%     Total 13/299 (4.35%)   Mean 4.34%   SD 2.33%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/50 (16%)    5/49 (10%)    6/50 (12%)          6/49 (12%)    2/50 (4%)     1/50 (2%)     |
|                                        6/50 (12%)    7/50 (14%)   12/50 (24%)          1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 44/299 (14.72%) Mean 14.7%   SD 4.97%     Total 10/299 (3.34%)   Mean 3.37%   SD 4.6%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   15/50 (30%)   16/49 (33%)   18/50 (36%)          7/49 (14%)    6/50 (12%)    4/50 (8%)     |
|      Alveolar/Bronchiolar Adenoma     17/50 (34%)   13/50 (26%)   22/50 (44%)          3/50 (6%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 101/299 (33.78%)Mean 33.78%  SD 6.09%     Total 23/299 (7.69%)   Mean 7.71%   SD 4.71%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      or Adenoma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/299 (0%)      Mean 0%      SD 0%        Total 1/298 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     1/50 (2%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     3/48 (6%)     0/47 (0%)     |
|                                                                                        2/50 (4%)     1/49 (2%)     1/48 (2%)     |
| Overall Incidence                                                               Total 8/291 (2.75%)    Mean 2.74%   SD 2.14%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          1/49 (2%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/291 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        1/49 (2%)     0/48 (0%)     0/47 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/291 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           1/49 (2%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
| Overall Incidence                                                               Total 2/291 (0.69%)    Mean 0.68%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/291 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/49 (2%)     1/48 (2%)     0/47 (0%)     |
|                                                                                        2/50 (4%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 4/291 (1.37%)    Mean 1.35%   SD 1.64%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     1/49 (2%)     0/48 (0%)     |
| Overall Incidence                                                               Total 1/291 (0.34%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/291 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/48 (0%)     0/47 (0%)     |
|                                                                                        0/50 (0%)     0/49 (0%)     0/48 (0%)     |
| Overall Incidence                                                               Total 0/291 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/48 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/295 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     0/48 (0%)          13/49 (27%)    8/47 (17%)   10/50 (20%)    |
|   Adenoma                              0/43 (0%)     0/49 (0%)     1/50 (2%)           9/48 (19%)   10/47 (21%)    8/49 (16%)    |
| Overall Incidence               Total 2/286 (0.7%)    Mean 0.68%   SD 1.05%     Total 58/290 (20%)     Mean 19.98%  SD 3.69%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/48 (0%)     0/48 (0%)           0/49 (0%)     0/47 (0%)     0/50 (0%)     |
|   Carcinoma                            0/43 (0%)     0/49 (0%)     1/50 (2%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/286 (0.35%)   Mean 0.33%   SD 0.82%     Total 0/290 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       1/48 (2%)     0/48 (0%)     0/48 (0%)          13/49 (27%)    8/47 (17%)   10/50 (20%)    |
|   Carcinoma or Adenoma                 0/43 (0%)     0/49 (0%)     2/50 (4%)           9/48 (19%)   10/47 (21%)    8/49 (16%)    |
| Overall Incidence               Total 3/286 (1.05%)   Mean 1.01%   SD 1.68%     Total 58/290 (20%)     Mean 19.98%  SD 3.69%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/48 (0%)           1/49 (2%)     1/47 (2%)     0/50 (0%)     |
|                                        0/43 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/286 (0%)      Mean 0%      SD 0%        Total 2/290 (0.69%)    Mean 0.69%   SD 1.08%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/48 (0%)     0/48 (0%)           1/49 (2%)     1/47 (2%)     0/50 (0%)     |
|                                        0/43 (0%)     0/49 (0%)     0/50 (0%)           0/48 (0%)     0/47 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/286 (0%)      Mean 0%      SD 0%        Total 2/290 (0.69%)    Mean 0.69%   SD 1.08%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/48 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        1/49 (2%)     0/46 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/291 (0.34%)   Mean 0.34%   SD 0.83%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/48 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        1/49 (2%)     0/46 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/291 (0.34%)   Mean 0.34%   SD 0.83%                                                      |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/48 (0%)     0/48 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/46 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/291 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/298 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                                                                                                                        |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 4/299 (1.34%)    Mean 1.33%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     3/50 (6%)     0/50 (0%)           2/49 (4%)     1/50 (2%)     0/50 (0%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1.33%   SD 2.42%     Total 7/299 (2.34%)    Mean 2.35%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     3/50 (6%)     0/50 (0%)           2/49 (4%)     1/50 (2%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|      Histiocytoma                                                                                                                |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1.33%   SD 2.42%     Total 7/299 (2.34%)    Mean 2.35%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.63%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                                                                                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           2/49 (4%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 2/300 (0.67%)   Mean 0.67%   SD 1.03%     Total 7/299 (2.34%)    Mean 2.35%   SD 1.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/49 (0%)     1/49 (2%)     2/50 (4%)           1/49 (2%)     0/49 (0%)     1/50 (2%)     |
|                                        2/48 (4%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     2/50 (4%)     |
| Overall Incidence               Total 5/295 (1.69%)   Mean 1.7%    SD 2.01%     Total 5/296 (1.69%)    Mean 1.68%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/295 (0%)      Mean 0%      SD 0%        Total 0/296 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 5/300 (1.67%)   Mean 1.67%   SD 1.97%     Total 3/299 (1%)       Mean 1%      SD 1.67%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
| Overall Incidence               Total 4/300 (1.33%)   Mean 1.33%   SD 1.63%     Total 2/299 (0.67%)    Mean 0.67%   SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)     1/50 (2%)     2/50 (4%)                                                     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)                                                     |
| Overall Incidence               Total 6/300 (2%)      Mean 2%      SD 1.79%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/44 (0%)     0/35 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/239 (0%)      Mean 0%      SD 0%        Total 0/276 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/44 (0%)     0/35 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/239 (0%)      Mean 0%      SD 0%        Total 0/276 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/44 (0%)     0/44 (0%)     0/35 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/239 (0%)      Mean 0%      SD 0%        Total 0/276 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/44 (0%)     0/35 (0%)           0/48 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/40 (0%)     0/41 (0%)     0/35 (0%)           0/45 (0%)     0/43 (0%)     0/44 (0%)     |
| Overall Incidence               Total 0/239 (0%)      Mean 0%      SD 0%        Total 0/276 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/48 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/48 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     0/47 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/289 (0%)      Mean 0%      SD 0%        Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/48 (0%)     0/49 (0%)     0/47 (0%)           1/49 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/48 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 2/289 (0.69%)   Mean 0.69%   SD 1.06%     Total 3/297 (1.01%)    Mean 1.01%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/48 (0%)     0/49 (0%)     1/47 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/48 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/289 (0.35%)   Mean 0.35%   SD 0.87%     Total 0/297 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     1/47 (2%)           1/49 (2%)     0/49 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/48 (0%)           0/49 (0%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 3/289 (1.04%)   Mean 1.04%   SD 1.14%     Total 3/297 (1.01%)    Mean 1.01%   SD 1.68%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/300 (0.33%)   Mean 0.33%   SD 0.82%     Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 2/294 (0.68%)   Mean 0.68%   SD 1.05%     Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 2/294 (0.68%)   Mean 0.68%   SD 1.05%     Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/48 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/48 (0%)     0/48 (0%)     |
| Overall Incidence               Total 0/294 (0%)      Mean 0%      SD 0%        Total 0/292 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.34%   SD 0.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/299 (0.33%)    Mean 0.33%   SD 0.82%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence                                                               Total 5/299 (1.67%)    Mean 1.67%   SD 1.97%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/299 (0.67%)    Mean 0.67%   SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     3/50 (6%)     2/50 (4%)     |
| Overall Incidence                                                               Total 7/299 (2.34%)    Mean 2.33%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/300 (0%)      Mean 0%      SD 0%        Total 0/299 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 69
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       27/50 (54%)                                     29/50 (58%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    29/50 (58%)                                     30/50 (60%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)                                     42/50 (84%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      3/50 (6%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        4/50 (8%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     1/50 (2%)                                      13/50 (26%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            1/50 (2%)                                       2/50 (4%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/43 (0%)                                       0/42 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/43 (0%)                                       0/42 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              5/50 (10%)                                      6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 7/50 (14%)                                      7/50 (14%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              17/50 (34%)                                     13/50 (26%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            12/50 (24%)                                      6/50 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         12/50 (24%)                                      6/50 (12%)                                |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         27/50 (54%)                                     17/50 (34%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           27/50 (54%)                                     17/50 (34%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             5/50 (10%)                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         9/50 (18%)                                      4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       5/50 (10%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   14/50 (28%)                                      4/50 (8%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)                                       1/50 (2%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       7/50 (14%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       7/50 (14%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      1/50 (2%)                                       4/50 (8%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)                                       4/50 (8%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       1/50 (2%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/42 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    1/42 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      1/42 (2%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       54/100(54%)                                     52/100(52%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    40/100(40%)                                     55/100(55%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         71/100(71%)                                     78/100(78%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        6/100(6%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/100(1%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     8/100(8%)                                      32/100(32%)                                |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/100(0%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              3/99 (3%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/99 (0%)                                       1/92 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              1/98 (1%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            2/98 (2%)                                       0/90 (0%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               1/99 (1%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/100(0%)                                       0/99 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 92
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/84 (0%)                                       0/70 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/84 (0%)                                       0/70 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                             12/100(12%)                                     10/100(10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                12/100(12%)                                     12/100(12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 93
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/99 (1%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            2/99 (2%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 3/99 (3%)                                       2/87 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            1/99 (1%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 2/99 (2%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      4/100(4%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/100(2%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              30/100(30%)                                     17/98 (17%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma            19/100(19%)                                      6/98 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         21/100(21%)                                      6/98 (6%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         46/100(46%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           47/100(47%)                                     22/98 (22%)                                |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/100(0%)                                       1/98 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/98 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        26/100(26%)                                      9/95 (9%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       8/100(8%)                                       2/95 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   30/100(30%)                                     11/95 (12%)                                |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/100(0%)                                       1/100(1%)                                 |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          3/79 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          2/79 (3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        2/79 (3%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/79 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/99 (0%)                                       0/87 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                       0/83 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/83 (0%)                                      17/83 (20%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/83 (0%)                                       1/83 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/98 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       1/94 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/100(0%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       1/100(1%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/100(0%)                                       1/100(1%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/100(0%)                                       1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 102
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       1/100(1%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 103
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/100(0%)                                       4/100(4%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/100(0%)                                       4/100(4%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       2/100(2%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       2/100(2%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 104
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/99 (2%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/99 (0%)                                       0/91 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/99 (0%)                                       1/91 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/100(0%)                                       1/100(1%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 105
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/99 (1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/99 (0%)                                                                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/99 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/69 (0%)                                       0/78 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/69 (0%)                                       1/78 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              1/99 (1%)                                       2/92 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 106
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/92 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 107
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/98 (0%)                                       0/79 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 108
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 109
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       37/50 (74%)   23/50 (46%)   26/50 (52%)         27/50 (54%)   13/50 (26%)   18/50 (36%)    |
|                                       34/50 (68%)   29/50 (58%)   30/60 (50%)         38/50 (76%)   35/50 (70%)   21/60 (35%)    |
|                                       25/50 (50%)   32/50 (64%)     0/0 (0%)          17/50 (34%)   15/50 (30%)   34/50 (68%)    |
|                                       25/49 (51%)                                     29/50 (58%)                                |
| Overall Incidence               Total 261/459 (56.86%)Mean 51.3%   SD 20.18%    Total 247/510 (48.43%) Mean 48.7%   SD 18.61%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    23/50 (46%)   20/50 (40%)   15/50 (30%)         17/50 (34%)   12/50 (24%)   20/50 (40%)    |
|                                       29/50 (58%)   27/50 (54%)   26/60 (43%)         33/50 (66%)   26/50 (52%)   16/60 (27%)    |
|                                       14/50 (28%)   29/50 (58%)     0/0 (0%)           9/50 (18%)   21/50 (42%)   43/50 (86%)    |
|                                       23/49 (47%)                                     36/50 (72%)                                |
| Overall Incidence               Total 206/459 (44.88%)Mean 40.43%  SD 17.58%    Total 233/510 (45.69%) Mean 46.07%  SD 22.48%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         45/50 (90%)   32/50 (64%)   34/50 (68%)         39/50 (78%)   23/50 (46%)   29/50 (58%)    |
|                                       45/50 (90%)   42/50 (84%)   45/60 (75%)         47/50 (94%)   47/50 (94%)   33/60 (55%)    |
|                                       31/50 (62%)   44/50 (88%)     0/0 (0%)          21/50 (42%)   31/50 (62%)   46/50 (92%)    |
|                                       37/49 (76%)                                     42/50 (84%)                                |
| Overall Incidence               Total 355/459 (77.34%)Mean 69.65%  SD 26.62%    Total 358/510 (70.2%)  Mean 70.5%   SD 20.24%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/60 (2%)           2/50 (4%)     2/50 (4%)     3/60 (5%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 3/459 (0.65%)   Mean 0.57%   SD 0.92%     Total 12/510 (2.35%)   Mean 2.3%    SD 2.31%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      4/50 (8%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|                                        1/50 (2%)     0/50 (0%)     4/60 (7%)           3/50 (6%)     4/50 (8%)     0/60 (0%)     |
|                                        1/50 (2%)     3/50 (6%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     8/50 (16%)    |
|                                        4/49 (8%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 20/459 (4.36%)  Mean 3.88%   SD 3.13%     Total 23/510 (4.51%)   Mean 4.6%    SD 4.81%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        5/50 (10%)    2/50 (4%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
|                                        1/50 (2%)     1/50 (2%)     5/60 (8%)           5/50 (10%)    6/50 (12%)    3/60 (5%)     |
|                                        1/50 (2%)     3/50 (6%)      0/0 (0%)           2/50 (4%)     0/50 (0%)     8/50 (16%)    |
|                                        4/49 (8%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 23/459 (5.01%)  Mean 4.45%   SD 3.43%     Total 34/510 (6.67%)   Mean 6.7%    SD 4.85%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/60 (2%)           0/50 (0%)     3/50 (6%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/459 (1.09%)   Mean 0.97%   SD 1.02%     Total 6/510 (1.18%)    Mean 1.2%    SD 1.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 110
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     2/50 (4%)     2/50 (4%)     3/50 (6%)           4/50 (8%)     6/50 (12%)    7/50 (14%)    |
|      Lymphocytic, Mixed, NOS, or       3/50 (6%)     2/50 (4%)     3/60 (5%)          23/50 (46%)   10/50 (20%)    8/60 (13%)    |
|      Undifferentiated Cell Type        3/50 (6%)     3/50 (6%)      0/0 (0%)           3/50 (6%)     7/50 (14%)   29/50 (58%)    |
|                                        0/49 (0%)                                      27/50 (54%)                                |
| Overall Incidence               Total 21/459 (4.58%)  Mean 4.1%    SD 2.33%     Total 124/510 (24.31%) Mean 24.53%  SD 19.97%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 3/510 (0.59%)    Mean 0.6%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              4/50 (8%)     0/50 (0%)     4/50 (8%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     5/50 (10%)    2/60 (3%)           1/50 (2%)     0/50 (0%)     1/59 (2%)     |
|                                        3/49 (6%)     3/49 (6%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/49 (6%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 27/457 (5.91%)  Mean 5.37%   SD 3.32%     Total 2/509 (0.39%)    Mean 0.37%   SD 0.78%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 111
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/509 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 1/509 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           1/50 (2%)     0/49 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/454 (0%)      Mean 0%      SD 0%        Total 4/507 (0.79%)    Mean 0.8%    SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           2/50 (4%)     0/49 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     1/49 (2%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/454 (0.44%)   Mean 0.41%   SD 0.86%     Total 3/507 (0.59%)    Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            0/49 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Complex, Malignant, NOS           0/49 (0%)     0/49 (0%)     0/60 (0%)           3/50 (6%)     0/49 (0%)     0/59 (0%)     |
|                                        0/49 (0%)     1/49 (2%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        1/49 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 2/454 (0.44%)   Mean 0.41%   SD 0.86%     Total 7/507 (1.38%)    Mean 1.4%    SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           1/50 (2%)     1/49 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/455 (0.66%)   Mean 0.6%    SD 0.97%     Total 4/509 (0.79%)    Mean 0.8%    SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Benign               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/455 (0%)      Mean 0%      SD 0%        Total 0/509 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 112
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Bone Marrow:                                                                                                                     |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     1/60 (2%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/455 (0.22%)   Mean 0.17%   SD 0.53%     Total 0/509 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chondrosarcoma or Chondroma          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 3/510 (0.59%)    Mean 0.6%    SD 0.97%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 113
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 114
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Coagulating Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor, Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.17%   SD 0.53%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 115
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Epididymis:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Adenoma                              0/48 (0%)     0/46 (0%)     0/44 (0%)           0/44 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/54 (0%)           0/40 (0%)     0/42 (0%)     0/54 (0%)     |
|                                        0/49 (0%)     0/44 (0%)      0/0 (0%)           0/49 (0%)     0/45 (0%)     0/46 (0%)     |
|                                        0/39 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/413 (0%)      Mean 0%      SD 0%        Total 0/463 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Gallbladder:                                                                                                                     |
|   Sarcoma                              0/48 (0%)     0/46 (0%)     0/44 (0%)           0/44 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/44 (0%)     0/45 (0%)     0/54 (0%)           0/40 (0%)     0/42 (0%)     0/54 (0%)     |
|                                        0/49 (0%)     0/44 (0%)      0/0 (0%)           0/49 (0%)     1/45 (2%)     0/46 (0%)     |
|                                        0/39 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/413 (0%)      Mean 0%      SD 0%        Total 1/463 (0.22%)    Mean 0.22%   SD 0.7%      |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              7/50 (14%)    9/50 (18%)    4/50 (8%)           7/50 (14%)    3/50 (6%)     6/50 (12%)    |
|                                        6/50 (12%)    9/50 (18%)    4/60 (7%)          11/50 (22%)    9/50 (18%)    4/60 (7%)     |
|                                        3/50 (6%)     4/50 (8%)      0/0 (0%)           2/50 (4%)     2/50 (4%)     3/50 (6%)     |
|                                        3/49 (6%)                                       9/50 (18%)                                |
| Overall Incidence               Total 49/459 (10.68%) Mean 9.68%   SD 5.75%     Total 56/510 (10.98%)  Mean 11.07%  SD 6.63%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            2/50 (4%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     1/60 (2%)           1/50 (2%)     1/50 (2%)     1/60 (2%)     |
|                                        0/50 (0%)     2/50 (4%)      0/0 (0%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 9/459 (1.96%)   Mean 1.77%   SD 1.75%     Total 9/510 (1.76%)    Mean 1.77%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 9/50 (18%)   10/50 (20%)    5/50 (10%)          7/50 (14%)    4/50 (8%)     7/50 (14%)    |
|                                        6/50 (12%)   10/50 (20%)    5/60 (8%)          12/50 (24%)   10/50 (20%)    5/60 (8%)     |
|                                        3/50 (6%)     6/50 (12%)     0/0 (0%)           2/50 (4%)     4/50 (8%)     4/50 (8%)     |
|                                        3/49 (6%)                                      10/50 (20%)                                |
| Overall Incidence               Total 57/459 (12.42%) Mean 11.25%  SD 6.59%     Total 65/510 (12.75%)  Mean 12.83%  SD 6.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 116
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/508 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.65%     Total 0/508 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/508 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 117
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Cecum                                                                                                           |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.4%    SD 0.84%     Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.17%   SD 0.53%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Duodenum                                                                                                        |
|   Polyp Adenomatous                    0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Ileum                                                                                                           |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 118
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/459 (1.31%)   Mean 1.13%   SD 1.57%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.65%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.4%    SD 0.84%     Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/459 (1.31%)   Mean 1.13%   SD 1.57%     Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     1/50 (2%)     2/60 (3%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/459 (1.74%)   Mean 1.53%   SD 1.99%     Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 119
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.17%   SD 0.53%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Polyp Adenomatous                    0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.4%    SD 0.85%     Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              2/50 (4%)     0/50 (0%)     0/49 (0%)           1/47 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/49 (6%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     3/49 (6%)     |
|                                        0/46 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 7/450 (1.56%)   Mean 1.42%   SD 2.15%     Total 5/498 (1%)       Mean 1.03%   SD 1.99%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/46 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     0/49 (0%)           1/47 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)     1/49 (2%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/49 (6%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     3/49 (6%)     |
|                                        0/46 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 7/450 (1.56%)   Mean 1.42%   SD 2.15%     Total 5/498 (1%)       Mean 1.03%   SD 1.99%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 3/453 (0.66%)   Mean 0.61%   SD 0.98%     Total 0/504 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/453 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/504 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 120
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 4/453 (0.88%)   Mean 0.81%   SD 1.04%     Total 0/504 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/58 (0%)           0/50 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/453 (0%)      Mean 0%      SD 0%        Total 0/504 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     1/50 (2%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/457 (0.44%)   Mean 0.41%   SD 0.86%     Total 0/506 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           2/49 (4%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 3/506 (0.59%)    Mean 0.61%   SD 1.38%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/48 (2%)     0/50 (0%)     1/60 (2%)           1/49 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        1/50 (2%)     2/50 (4%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        1/49 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 8/457 (1.75%)   Mean 1.58%   SD 1.26%     Total 5/506 (0.99%)    Mean 1.01%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatoblastoma                       2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        6/48 (13%)    0/50 (0%)     1/60 (2%)           1/49 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/50 (6%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 12/457 (2.63%)  Mean 2.42%   SD 4.12%     Total 3/506 (0.59%)    Mean 0.61%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma              23/50 (46%)    7/50 (14%)   17/50 (34%)         11/50 (22%)    3/50 (6%)     4/50 (8%)     |
|                                       30/48 (63%)   18/50 (36%)   18/60 (30%)         30/49 (61%)   21/50 (42%)    7/60 (12%)    |
|                                       14/50 (28%)   16/50 (32%)     0/0 (0%)           6/49 (12%)    9/49 (18%)   24/50 (48%)    |
|                                       18/49 (37%)                                     19/49 (39%)                                |
| Overall Incidence               Total 161/457 (35.23%)Mean 31.92%  SD 16.79%    Total 134/506 (26.48%) Mean 26.83%  SD 19.24%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 121
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             8/50 (16%)    4/50 (8%)    10/50 (20%)          3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|                                       20/48 (42%)   20/50 (40%)   12/60 (20%)          3/49 (6%)    10/50 (20%)    2/60 (3%)     |
|                                        8/50 (16%)   23/50 (46%)     0/0 (0%)           3/49 (6%)     8/49 (16%)   13/50 (26%)    |
|                                       14/49 (29%)                                      3/49 (6%)                                 |
| Overall Incidence               Total 119/457 (26.04%)Mean 23.62%  SD 15.14%    Total 48/506 (9.49%)   Mean 9.6%    SD 8.16%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         10/50 (20%)    4/50 (8%)    10/50 (20%)          3/50 (6%)     2/50 (4%)     1/50 (2%)     |
|      Hepatoblastoma                   23/48 (48%)   20/50 (40%)   13/60 (22%)          4/49 (8%)    10/50 (20%)    2/60 (3%)     |
|                                        8/50 (16%)   24/50 (48%)     0/0 (0%)           3/49 (6%)     8/49 (16%)   14/50 (28%)    |
|                                       14/49 (29%)                                      4/49 (8%)                                 |
| Overall Incidence               Total 126/457 (27.57%)Mean 25.02%  SD 16.15%    Total 51/506 (10.08%)  Mean 10.21%  SD 8.47%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or         31/50 (62%)   10/50 (20%)   23/50 (46%)         13/50 (26%)    4/50 (8%)     5/50 (10%)    |
|      Hepatocellular Adenoma           41/48 (85%)   35/50 (70%)   27/60 (45%)         31/49 (63%)   29/50 (58%)    9/60 (15%)    |
|                                       20/50 (40%)   36/50 (72%)     0/0 (0%)           8/49 (16%)   16/49 (33%)   30/50 (60%)    |
|                                       28/49 (57%)                                     22/49 (45%)                                |
| Overall Incidence               Total 251/457 (54.92%)Mean 49.76%  SD 25.55%    Total 167/506 (33%)    Mean 33.41%  SD 21.64%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,           31/50 (62%)   10/50 (20%)   23/50 (46%)         13/50 (26%)    4/50 (8%)     5/50 (10%)    |
|      Hepatocellular Adenoma, or       41/48 (85%)   35/50 (70%)   28/60 (47%)         31/49 (63%)   29/50 (58%)    9/60 (15%)    |
|      Hepatoblastoma                   20/50 (40%)   36/50 (72%)     0/0 (0%)           8/49 (16%)   16/49 (33%)   31/50 (62%)    |
|                                       28/49 (57%)                                     22/49 (45%)                                |
| Overall Incidence               Total 252/457 (55.14%)Mean 49.92%  SD 25.52%    Total 168/506 (33.2%)  Mean 33.61%  SD 21.92%    |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocholangiocarcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/457 (0.44%)   Mean 0.4%    SD 1.26%     Total 0/506 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 2/506 (0.4%)     Mean 0.41%   SD 0.86%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.65%     Total 0/509 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 122
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma        11/50 (22%)   11/50 (22%)    8/50 (16%)          2/49 (4%)     4/50 (8%)     0/50 (0%)     |
|                                        6/50 (12%)    6/50 (12%)    9/60 (15%)          3/50 (6%)     4/50 (8%)     2/60 (3%)     |
|                                        6/50 (12%)   12/50 (24%)     0/0 (0%)           5/50 (10%)    1/50 (2%)     6/50 (12%)    |
|                                        7/49 (14%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 76/459 (16.56%) Mean 14.93%  SD 6.93%     Total 28/509 (5.5%)    Mean 5.54%   SD 3.9%      |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       9/50 (18%)    6/50 (12%)    2/50 (4%)           0/49 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        4/50 (8%)     2/50 (4%)     5/60 (8%)           1/50 (2%)     0/50 (0%)     3/60 (5%)     |
|                                        2/50 (4%)     7/50 (14%)     0/0 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        5/49 (10%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 42/459 (9.15%)  Mean 8.25%   SD 5.46%     Total 11/509 (2.16%)   Mean 2.1%    SD 2.02%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or   19/50 (38%)   14/50 (28%)    9/50 (18%)          2/49 (4%)     4/50 (8%)     3/50 (6%)     |
|      Alveolar/Bronchiolar Adenoma     10/50 (20%)    8/50 (16%)   14/60 (23%)          4/50 (8%)     4/50 (8%)     5/60 (8%)     |
|                                        8/50 (16%)   18/50 (36%)     0/0 (0%)           6/50 (12%)    2/50 (4%)     6/50 (12%)    |
|                                       12/49 (24%)                                      2/50 (4%)                                 |
| Overall Incidence               Total 112/459 (24.4%) Mean 21.98%  SD 10.91%    Total 38/509 (7.47%)   Mean 7.44%   SD 2.99%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/509 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/509 (0.2%)     Mean 0.2%    SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Bronchial:                                                                                                           |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mandibular:                                                                                                          |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 123
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mediastinal:                                                                                                         |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Plasma Cell Tumor Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 2/510 (0.39%)    Mean 0.37%   SD 0.78%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 124
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Lymph Node:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 4/510 (0.78%)    Mean 0.8%    SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 4/510 (0.78%)    Mean 0.8%    SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|      or Adenoma                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 4/510 (0.78%)    Mean 0.8%    SD 1.03%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 125
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 126
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 3/510 (0.59%)    Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          1/49 (2%)     0/50 (0%)     2/48 (4%)     |
|                                                                                        1/45 (2%)     1/49 (2%)     1/59 (2%)     |
|                                                                                        3/48 (6%)     1/49 (2%)     4/50 (8%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 14/496 (2.82%)   Mean 2.85%   SD 2.58%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 127
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/49 (0%)     0/50 (0%)     2/48 (4%)     |
|                                                                                        1/45 (2%)     1/49 (2%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 6/496 (1.21%)    Mean 1.25%   SD 1.46%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/49 (0%)     0/50 (0%)     2/48 (4%)     |
|      Malignant, NOS                                                                    1/45 (2%)     1/49 (2%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 6/496 (1.21%)    Mean 1.25%   SD 1.46%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangioma                                                                           0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        1/48 (2%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 1/496 (0.2%)     Mean 0.21%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Hemangiosarcoma                                                                      0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     1/49 (2%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     2/50 (4%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 3/496 (0.6%)     Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/49 (2%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        3/45 (7%)     0/49 (0%)     2/59 (3%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 6/496 (1.21%)    Mean 1.21%   SD 2.25%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Teratoma Benign                                                                      0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 0/496 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Benign                                                                       0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 0/496 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 128
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/49 (0%)     0/50 (0%)     0/48 (0%)     |
|                                                                                        0/45 (0%)     0/49 (0%)     0/59 (0%)     |
|                                                                                        0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)                                 |
| Overall Incidence                                                               Total 0/496 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/46 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/47 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/46 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     1/49 (2%)     0/50 (0%)     |
|                                        0/46 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/450 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.2%    SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/49 (0%)     0/49 (0%)           2/46 (4%)     1/50 (2%)     5/49 (10%)    |
|   Adenoma                              0/47 (0%)     0/48 (0%)     1/53 (2%)           3/46 (7%)     4/48 (8%)     3/58 (5%)     |
|                                        0/46 (0%)     1/49 (2%)      0/0 (0%)           0/45 (0%)     5/48 (10%)    3/49 (6%)     |
|                                        0/45 (0%)                                       2/47 (4%)                                 |
| Overall Incidence               Total 2/434 (0.46%)   Mean 0.39%   SD 0.83%     Total 28/486 (5.76%)   Mean 5.74%   SD 3.34%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/49 (0%)     0/49 (0%)           0/46 (0%)     0/50 (0%)     0/49 (0%)     |
|   Carcinoma                            0/47 (0%)     0/48 (0%)     0/53 (0%)           0/46 (0%)     1/48 (2%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)      0/0 (0%)           0/45 (0%)     0/48 (0%)     0/49 (0%)     |
|                                        0/45 (0%)                                       0/47 (0%)                                 |
| Overall Incidence               Total 0/434 (0%)      Mean 0%      SD 0%        Total 1/486 (0.21%)    Mean 0.21%   SD 0.66%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/48 (0%)     0/49 (0%)     0/49 (0%)           2/46 (4%)     1/50 (2%)     5/49 (10%)    |
|   Carcinoma or Adenoma                 0/47 (0%)     0/48 (0%)     1/53 (2%)           3/46 (7%)     5/48 (10%)    3/58 (5%)     |
|                                        0/46 (0%)     1/49 (2%)      0/0 (0%)           0/45 (0%)     5/48 (10%)    3/49 (6%)     |
|                                        0/45 (0%)                                       2/47 (4%)                                 |
| Overall Incidence               Total 2/434 (0.46%)   Mean 0.39%   SD 0.83%     Total 29/486 (5.97%)   Mean 5.95%   SD 3.58%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/48 (0%)     0/49 (0%)     0/49 (0%)           2/46 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/53 (0%)           0/46 (0%)     0/48 (0%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)      0/0 (0%)           0/45 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/45 (0%)                                       1/47 (2%)                                 |
| Overall Incidence               Total 0/434 (0%)      Mean 0%      SD 0%        Total 5/486 (1.03%)    Mean 1.06%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 129
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/48 (0%)     0/49 (0%)     0/49 (0%)           2/46 (4%)     0/50 (0%)     0/49 (0%)     |
|                                        0/47 (0%)     0/48 (0%)     0/53 (0%)           0/46 (0%)     0/48 (0%)     0/58 (0%)     |
|                                        0/46 (0%)     0/49 (0%)      0/0 (0%)           0/45 (0%)     0/48 (0%)     2/49 (4%)     |
|                                        0/45 (0%)                                       1/47 (2%)                                 |
| Overall Incidence               Total 0/434 (0%)      Mean 0%      SD 0%        Total 5/486 (1.03%)    Mean 1.06%   SD 1.79%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/48 (0%)                                                                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/48 (0%)                                                                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/49 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/48 (0%)                                                                                 |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/506 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/48 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/506 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 130
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Seminal Vesicle:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.17%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           5/50 (10%)    0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 9/510 (1.76%)    Mean 1.8%    SD 3.19%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 131
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      NOS)                              0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 132
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Sq Papilloma,          0/49 (0%)                                       0/50 (0%)                                 |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 3/459 (0.65%)   Mean 0.6%    SD 1.35%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 2/510 (0.39%)    Mean 0.4%    SD 1.26%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     4/50 (8%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.4%    SD 0.84%     Total 11/510 (2.16%)   Mean 2.2%    SD 2.57%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Mast Cell Tumor Malignant            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 133
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Carcinoma                         0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.4%    SD 0.84%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.4%    SD 0.84%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Carcinoma or Keratoacanthoma      1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/459 (0.65%)   Mean 0.6%    SD 1.35%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 134
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/459 (0.65%)   Mean 0.6%    SD 1.35%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.4%    SD 0.85%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      Myxoma, Myxosarcoma, or Fibrous   0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)      0/0 (0%)           2/50 (4%)     3/50 (6%)     5/50 (10%)    |
|                                        1/49 (2%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 3/459 (0.65%)   Mean 0.6%    SD 0.97%     Total 18/510 (3.53%)   Mean 3.57%   SD 3.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 5/510 (0.98%)    Mean 1%      SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|      Myxosarcoma, or Fibrous           0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|      Histiocytoma                      0/50 (0%)     0/50 (0%)      0/0 (0%)           2/50 (4%)     3/50 (6%)     5/50 (10%)    |
|                                        0/49 (0%)                                       4/50 (8%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 18/510 (3.53%)   Mean 3.57%   SD 3.52%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 3/510 (0.59%)    Mean 0.6%    SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 135
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/60 (0%)           3/50 (6%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 4/510 (0.78%)    Mean 0.8%    SD 1.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/60 (0%)           3/50 (6%)     0/50 (0%)     0/60 (0%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 4/510 (0.78%)    Mean 0.8%    SD 1.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           1/50 (2%)     3/50 (6%)     4/50 (8%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 11/510 (2.16%)   Mean 2.17%   SD 2.75%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           3/50 (6%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 4/510 (0.78%)    Mean 0.8%    SD 1.93%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     1/60 (2%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/451 (0.22%)   Mean 0.17%   SD 0.53%     Total 1/502 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      2/49 (4%)     1/50 (2%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     2/49 (4%)     |
|                                        0/48 (0%)     0/49 (0%)     2/60 (3%)           2/49 (4%)     1/49 (2%)     0/59 (0%)     |
|                                        0/50 (0%)     1/49 (2%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     4/50 (8%)     |
|                                        2/47 (4%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/451 (1.77%)   Mean 1.57%   SD 1.81%     Total 9/502 (1.79%)    Mean 1.82%   SD 2.76%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Mast Cell Tumor Malignant            0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/60 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/451 (0%)      Mean 0%      SD 0%        Total 0/502 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 136
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Plasma Cell Tumor Malignant          0/49 (0%)     0/50 (0%)     0/49 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/60 (0%)           0/49 (0%)     0/49 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/47 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/451 (0%)      Mean 0%      SD 0%        Total 0/502 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.17%   SD 0.53%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.4%    SD 0.85%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           2/50 (4%)     0/50 (0%)     1/50 (2%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|      Papilloma Squamous                0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 7/459 (1.53%)   Mean 1.4%    SD 1.35%     Total 9/510 (1.76%)    Mean 1.77%   SD 1.75%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     2/50 (4%)     2/50 (4%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 5/459 (1.09%)   Mean 1%      SD 1.41%     Total 9/510 (1.76%)    Mean 1.77%   SD 1.75%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 137
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        1/49 (2%)                                                                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.65%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Seratoli Tumor: Benign,              0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|      Malignant, NOS                    0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Sertoli Cell Tumor Malignant         0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)                                                     |
|                                        0/49 (0%)                                                                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%                                                      |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Hemangioma                           0/44 (0%)     0/47 (0%)     0/48 (0%)           0/44 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/47 (0%)     0/57 (0%)           0/48 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)      0/0 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/42 (0%)                                       0/44 (0%)                                 |
| Overall Incidence               Total 0/417 (0%)      Mean 0%      SD 0%        Total 0/484 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 138
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/44 (0%)     0/47 (0%)     0/48 (0%)           0/44 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/47 (0%)     0/57 (0%)           0/48 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)      0/0 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/42 (0%)                                       0/44 (0%)                                 |
| Overall Incidence               Total 0/417 (0%)      Mean 0%      SD 0%        Total 0/484 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/44 (0%)     0/47 (0%)     0/48 (0%)           0/44 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/47 (0%)     0/57 (0%)           0/48 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)      0/0 (0%)           0/48 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/42 (0%)                                       0/44 (0%)                                 |
| Overall Incidence               Total 0/417 (0%)      Mean 0%      SD 0%        Total 1/484 (0.21%)    Mean 0.2%    SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/44 (0%)     0/47 (0%)     0/48 (0%)           0/44 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/43 (0%)     0/47 (0%)     0/57 (0%)           0/48 (0%)     0/46 (0%)     0/57 (0%)     |
|                                        0/47 (0%)     0/42 (0%)      0/0 (0%)           0/48 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/42 (0%)                                       0/44 (0%)                                 |
| Overall Incidence               Total 0/417 (0%)      Mean 0%      SD 0%        Total 1/484 (0.21%)    Mean 0.2%    SD 0.65%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/453 (0%)      Mean 0%      SD 0%        Total 1/505 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/453 (0%)      Mean 0%      SD 0%        Total 0/505 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/453 (0%)      Mean 0%      SD 0%        Total 0/505 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/50 (2%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     1/59 (2%)           1/48 (2%)     3/50 (6%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/48 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 3/453 (0.66%)   Mean 0.57%   SD 0.92%     Total 11/505 (2.18%)   Mean 2.22%   SD 2.39%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 139
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/59 (0%)           0/48 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/48 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/453 (0%)      Mean 0%      SD 0%        Total 0/505 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     1/59 (2%)           1/48 (2%)     3/50 (6%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)      0/0 (0%)           0/50 (0%)     0/49 (0%)     2/50 (4%)     |
|                                        0/48 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 3/453 (0.66%)   Mean 0.57%   SD 0.92%     Total 11/505 (2.18%)   Mean 2.22%   SD 2.39%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/459 (0.44%)   Mean 0.33%   SD 1.05%     Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 2/510 (0.39%)    Mean 0.4%    SD 1.26%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 140
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/505 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/457 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/505 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/505 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/505 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 141
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 1/505 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/510 (0.39%)    Mean 0.4%    SD 0.84%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Deciduoma Benign                                                                     0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 2/510 (0.39%)    Mean 0.37%   SD 0.78%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangiosarcoma                                                                      0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/510 (0.59%)    Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 142
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     4/50 (8%)     2/60 (3%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 11/510 (2.16%)   Mean 2.13%   SD 2.86%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/510 (0.59%)    Mean 0.6%    SD 1.35%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     4/50 (8%)     2/60 (3%)     |
|                                                                                        3/50 (6%)     0/50 (0%)     2/50 (4%)     |
|                                                                                        1/50 (2%)                                 |
| Overall Incidence                                                               Total 14/510 (2.75%)   Mean 2.73%   SD 2.67%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 0/510 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 143
 Version: 01/26/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: MICE                                           Vehicle: ALL VEHICLES                             Input File: 26-JAN-2005
 Strain: B6C3F1
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/459 (0%)      Mean 0%      SD 0%        Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)      0/0 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/459 (0.22%)   Mean 0.2%    SD 0.63%     Total 1/510 (0.2%)     Mean 0.2%    SD 0.63%     |
 __________________________________________________________________________________________________________________________________
