                                                 Toxicology Data Management System                                     Page: 1
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058813803  08/16/99   729       50(3)      22  (681)    501.7     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634803  06/06/96   726      100(3)      52  (681)    492.7     CITRAL                                     |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(3)      23  (662)    519.6     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812206  06/25/97   727       50(3)      26  (667)    483.6     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805005  10/30/95   729       50(3)      25  (665)    488.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   729       50(3)      24  (659)    496.8     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   729       50(3)      29  (665)    502.2     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611103  09/08/97   731      100(3)      60  (689)    492.1     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE COLUMBUS  058813803  08/16/99   729       50(5)      32  (688)    348.7     BENZOPHENONE                               |
|BATTELLE COLUMBUS  055634803  06/06/96   732      100(5)      75  (705)    335.2     CITRAL                                     |
|BATTELLE COLUMBUS  058803105  03/31/97   729       50(5)      30  (683)    350.8     DIPROPYLENE GLYCOL                         |
|BATTELLE COLUMBUS  058812206  06/25/97   728       50(5)      30  (672)    327.2     ELMIRON (SODIUM PENTOSANPOLYSULFATE)       |
|BATTELLE COLUMBUS  058805005  10/30/95   731       50(5)      38  (710)    315.4     METHACRYLONITRILE                          |
|BATTELLE COLUMBUS  058812003  12/18/95   730       50(5)      36  (694)    330.5     P,P'-DICHLORODIPHENYL SULFONE              |
|BATTELLE COLUMBUS  058800705  08/14/95   730       50(5)      33  (695)    350.1     SODIUM NITRITE                             |
|BATTELLE COLUMBUS  055611103  09/08/97   735      100(5)      70  (706)    344.4     TRANS-CINNAMALDEHYDE                       |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 2
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302607  08/14/97   733       50( )      28  (684)    506.2     DECALIN                                    |
|BATTELLE NORTHWEST 058800405  09/13/99   729       50( )      31  (686)    519.5     DIVINYLBENZENE                             |
|BATTELLE NORTHWEST 058812403  01/18/96   733       50( )      27  (667)    501.0     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   733       49( )      24  (681)    507.1     NAPHTHALENE                                |
|BATTELLE NORTHWEST 059000407  10/06/97   729       50( )      27  (675)    540.3     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600105  01/18/99   729       50( )      29  (701)    534.2     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142707  01/06/97   729       50( )      20  (668)    518.0     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE NORTHWEST 059302607  08/14/97   734       50( )      32  (700)    345.9     DECALIN                                    |
|BATTELLE NORTHWEST 058800405  09/13/99   731       50( )      33  (679)    355.3     DIVINYLBENZENE                             |
|BATTELLE NORTHWEST 058812403  01/18/96   735       50( )      34  (682)    337.2     INDIUM PHOSPHIDE                           |
|BATTELLE NORTHWEST 050511002  03/28/96   734       49( )      28  (700)    325.2     NAPHTHALENE                                |
|BATTELLE NORTHWEST 059000407  10/06/97   730       50( )      33  (675)    366.9     PROPYLENE GLYCOL MONO-T-BUTYL ETHER        |
|BATTELLE NORTHWEST 059600105  01/18/99   730       50( )      36  (696)    362.8     STODDARD SOLVENT (TYPE IIC)                |
|BATTELLE NORTHWEST 056142707  01/06/97   731       50( )      33  (688)    351.1     VANADIUM PENTOXIDE                         |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 3
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE TOXICOLOGY059700601T 05/25/00   726       50( )      32  (693)    529.3     METHYL ISOBUTYL KETONE                     |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|BATTELLE TOXICOLOGY059700601T 05/25/00   727       50( )      35  (694)    365.6     METHYL ISOBUTYL KETONE                     |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 4
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902905  09/26/94   736      100(5)      57  (692)    498.3     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|IITRI              058902905  09/26/94   737      100(5)      59  (692)    338.0     MAGNETIC FIELDS (EMF)                      |
|________________________________________________________________________________________________________________________________|
                                                 Toxicology Data Management System                                     Page: 5
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                            Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   

                                                         Study Summary

 ________________________________________________________________________________________________________________________________
|                                                                                                                                |
|                                       Length     Number       Number      Maximum                                              |
|                               Study     of     of Animals    Surviving     Mean                                                |
|Laboratory          Study      Start   Study    Total and     and (Mean  Weekly Body                                            |
|Name                Number     Date   in Days    (#/Cage)     Life Span)   Weight             Chemical                          |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                        MALE                                                                    |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302306  07/11/97   729       50(3)      37  (693)    510.6     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201205  07/15/98   729       50(3)      35  (704)    446.9     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059201305  01/20/00   730       50(3)      31  (702)    448.0     4-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601003  09/16/98   729       50(3)      36  (687)    514.1     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  059302007  04/24/00   729       50(1)      20  (670)    484.2     DIISOPROPYLCARBODIIMIDE                    |
|SOUTHERN RESEARCH  050520308  02/08/96   729       60(3)      39  (698)    447.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(3)      31  (697)    443.8     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  059601803  12/15/98   729       50(3)      29  (682)    511.6     BROMODICHLOROMETHANE                       |
|SOUTHERN RESEARCH  059601705  03/08/00   729       50(3)      34  (683)    522.9     DIBROMOACETIC ACID                         |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|                                                       FEMALE                                                                   |
|________________________________________________________________________________________________________________________________|
|                                                                                                                                |
|SOUTHERN RESEARCH  059302306  07/11/97   732       50(5)      37  (699)    314.6     2,4-HEXADIENAL                             |
|SOUTHERN RESEARCH  059201205  07/15/98   734       50(5)      40  (707)    320.6     2-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059201305  01/20/00   735       50(5)      40  (702)    311.3     4-METHYLIMIDAZOLE                          |
|SOUTHERN RESEARCH  059601003  09/16/98   734       50(5)      37  (699)    341.7     SODIUM DICHLORATE                          |
|SOUTHERN RESEARCH  059302007  04/24/00   731       50(1)      30  (672)    319.5     DIISOPROPYLCARBODIIMIDE                    |
|SOUTHERN RESEARCH  050520308  02/08/96   730       60(5)      47  (713)    299.3     O-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050520507  11/28/95   729       50(5)      39  (702)    295.2     P-NITROTOLUENE                             |
|SOUTHERN RESEARCH  050516105  03/06/96   729       50(5)      33  (683)    322.1     RIDDELLIINE                                |
|SOUTHERN RESEARCH  059601705  03/08/00   734       50(5)      35  (693)    350.5     DIBROMOACETIC ACID                         |
|________________________________________________________________________________________________________________________________|

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 7
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       49/50 (98%)   97/100(97%)   47/50 (94%)         42/50 (84%)   78/100(78%)   44/50 (88%)    |
|                                       49/50 (98%)   47/50 (94%)   42/50 (84%)         37/50 (74%)   35/50 (70%)   37/50 (74%)    |
|                                       47/50 (94%)   99/100(99%)                       42/50 (84%)   78/100(78%)                  |
| Overall Incidence               Total 477/500 (95.4%) Mean 94.75%  SD 4.8%      Total 393/500 (78.6%)  Mean 78.75%  SD 6.14%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    33/50 (66%)   76/100(76%)   35/50 (70%)         20/50 (40%)   30/100(30%)   25/50 (50%)    |
|                                       29/50 (58%)   29/50 (58%)   34/50 (68%)         12/50 (24%)   26/50 (52%)   16/50 (32%)    |
|                                       30/50 (60%)   57/100(57%)                       23/50 (46%)   39/100(39%)                  |
| Overall Incidence               Total 323/500 (64.6%) Mean 64.13%  SD 6.94%     Total 191/500 (38.2%)  Mean 39.13%  SD 9.96%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)  99/100(99%)   49/50 (98%)         46/50 (92%)   92/100(92%)   50/50 (100%)   |
|                                       49/50 (98%)   49/50 (98%)   49/50 (98%)         42/50 (84%)   45/50 (90%)   43/50 (86%)    |
|                                       49/50 (98%)  100/100(100%)                      45/50 (90%)   92/100(92%)                  |
| Overall Incidence               Total 494/500 (98.8%) Mean 98.63%  SD 0.92%     Total 455/500 (91%)    Mean 90.75%  SD 4.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 2/500 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 3/500 (0.6%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   27/50 (54%)   68/100(68%)   16/50 (32%)         19/50 (38%)   24/100(24%)   10/50 (20%)    |
|      Mononuclear, or Undifferentiated 15/50 (30%)   20/50 (40%)   27/50 (54%)          7/50 (14%)   21/50 (42%)    8/50 (16%)    |
|                                       17/50 (34%)   40/100(40%)                       15/50 (30%)   21/100(21%)                  |
| Overall Incidence               Total 230/500 (46%)   Mean 44%     SD 13.35%    Total 125/500 (25%)    Mean 25.63%  SD 10.17%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 8
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 2/500 (0.4%)     Mean 0.25%   SD 0.46%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     2/50 (4%)     4/100(4%)     6/50 (12%)          0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      NOS                               2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     5/100(5%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 24/500 (4.8%)   Mean 4.88%   SD 3.36%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              2/50 (4%)     4/100(4%)     6/50 (12%)          0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     5/100(5%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 24/500 (4.8%)   Mean 4.88%   SD 3.36%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.75%   SD 1.04%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.75%   SD 1.04%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     2/100(2%)     0/47 (0%)           0/50 (0%)     2/100(2%)     1/49 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     2/50 (4%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 3/497 (0.6%)    Mean 0.5%    SD 0.93%     Total 9/499 (1.8%)     Mean 1.88%   SD 1.13%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 9
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/100(0%)     1/47 (2%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.39%   SD 0.78%     Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              8/50 (16%)   10/100(10%)    4/47 (9%)           0/50 (0%)     3/99 (3%)     0/49 (0%)     |
|                                        7/50 (14%)    3/50 (6%)     4/50 (8%)           2/50 (4%)     1/50 (2%)     2/50 (4%)     |
|                                        6/50 (12%)    5/100(5%)                         4/50 (8%)     1/100(1%)                   |
| Overall Incidence               Total 47/497 (9.46%)  Mean 9.94%   SD 3.84%     Total 13/498 (2.61%)   Mean 2.75%   SD 2.66%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     1/100(1%)     0/47 (0%)           0/50 (0%)     0/99 (0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 1/497 (0.2%)    Mean 0.13%   SD 0.35%     Total 1/498 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/100(0%)     5/47 (11%)          0/50 (0%)     0/99 (0%)     2/49 (4%)     |
|                                        1/50 (2%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 10/497 (2.01%)  Mean 2.58%   SD 3.54%     Total 5/498 (1%)       Mean 1.01%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            8/50 (16%)   11/100(11%)    9/47 (19%)          0/50 (0%)     3/99 (3%)     2/49 (4%)     |
|      Complex, Malignant, NOS           7/50 (14%)    4/50 (8%)     6/50 (12%)          3/50 (6%)     1/50 (2%)     2/50 (4%)     |
|                                        7/50 (14%)    5/100(5%)                         4/50 (8%)     4/100(4%)                   |
| Overall Incidence               Total 57/497 (11.47%) Mean 12.39%  SD 4.47%     Total 19/498 (3.82%)   Mean 3.89%   SD 2.42%     |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 10
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 11
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 3/500 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     7/100(7%)     3/50 (6%)           3/50 (6%)    15/98 (15%)    6/48 (13%)    |
|                                        1/50 (2%)     2/50 (4%)     3/50 (6%)           3/50 (6%)     2/49 (4%)     1/47 (2%)     |
|                                        0/50 (0%)     7/100(7%)                         8/46 (17%)    4/99 (4%)                   |
| Overall Incidence               Total 23/500 (4.6%)   Mean 4%      SD 2.98%     Total 42/487 (8.62%)   Mean 8.43%   SD 5.78%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/50 (2%)     1/100(1%)     3/50 (6%)           1/50 (2%)     1/98 (1%)     5/48 (10%)    |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/47 (0%)     |
|                                        5/50 (10%)    4/100(4%)                         2/46 (4%)     9/99 (9%)                   |
| Overall Incidence               Total 16/500 (3.2%)   Mean 3.38%   SD 3.25%     Total 19/487 (3.9%)    Mean 3.61%   SD 4.05%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)     8/100(8%)     6/50 (12%)          4/50 (8%)    16/98 (16%)   10/48 (21%)    |
|                                        2/50 (4%)     3/50 (6%)     3/50 (6%)           3/50 (6%)     3/49 (6%)     1/47 (2%)     |
|                                        5/50 (10%)   11/100(11%)                       10/46 (22%)   13/99 (13%)                  |
| Overall Incidence               Total 39/500 (7.8%)   Mean 7.38%   SD 3.5%      Total 60/487 (12.32%)  Mean 11.79%  SD 7.33%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/49 (2%)     0/47 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/46 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/487 (0.21%)    Mean 0.26%   SD 0.72%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 12
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/98 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/46 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/487 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/98 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/46 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/487 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/98 (0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/46 (0%)     0/99 (0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/487 (0.21%)    Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Amelanotic Melanoma, Benign          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/50 (0%)     0/100(0%)     0/50 (0%)           1/50 (2%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 13
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/100(0%)     2/50 (4%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 1.41%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)     0/100(0%)     0/50 (0%)           1/50 (2%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.75%   SD 1.04%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 14
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 15
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              1/50 (2%)     3/99 (3%)     2/44 (5%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 13/493 (2.64%)  Mean 2.7%    SD 2.61%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/99 (0%)     0/44 (0%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 2/493 (0.41%)   Mean 0.5%    SD 0.93%     Total 2/497 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 1/50 (2%)     3/99 (3%)     2/44 (5%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        5/50 (10%)    2/100(2%)                         0/50 (0%)     2/100(2%)                   |
| Overall Incidence               Total 15/493 (3.04%)  Mean 3.2%    SD 3.03%     Total 2/497 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/100(0%)     1/47 (2%)           0/50 (0%)     1/100(1%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.52%   SD 0.96%     Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 16
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     1/100(1%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 1/499 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/100(0%)     1/47 (2%)           0/50 (0%)     2/100(2%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.52%   SD 0.96%     Total 2/499 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/100(0%)     1/47 (2%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/497 (0.2%)    Mean 0.27%   SD 0.75%     Total 0/499 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 17
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 5/500 (1%)      Mean 1%      SD 1.51%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 1.41%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 1.41%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Hepatocellular Adenoma            0/50 (0%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 7/500 (1.4%)    Mean 1.5%    SD 1.77%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            2/50 (4%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        0/50 (0%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     2/100(2%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 7/500 (1.4%)    Mean 1.5%    SD 1.77%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         4/50 (8%)     3/100(3%)     2/50 (4%)           4/50 (8%)     2/100(2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     4/100(4%)                         3/50 (6%)     6/100(6%)                   |
| Overall Incidence               Total 17/500 (3.4%)   Mean 3.38%   SD 2.56%     Total 15/500 (3%)      Mean 2.75%   SD 3.37%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.88%   SD 1.46%     Total 3/500 (0.6%)     Mean 0.5%    SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 18
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    4/50 (8%)     3/100(3%)     3/50 (6%)           4/50 (8%)     3/100(3%)     1/50 (2%)     |
|      Alveolar/Bronchiolar Adenoma      2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/100(5%)                         3/50 (6%)     7/100(7%)                   |
| Overall Incidence               Total 21/500 (4.2%)   Mean 4.25%   SD 2.31%     Total 18/500 (3.6%)    Mean 3.25%   SD 3.33%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 19
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     1/100(1%)     0/50 (0%)           2/50 (4%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         2/50 (4%)     1/100(1%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 7/500 (1.4%)     Mean 1.63%   SD 1.69%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     4/50 (8%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.71%     Total 11/500 (2.2%)    Mean 2.63%   SD 2.88%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     3/100(3%)     0/50 (0%)           2/50 (4%)     0/100(0%)     4/50 (8%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     3/50 (6%)     2/50 (4%)     |
|                                        0/50 (0%)     0/100(0%)                         2/50 (4%)     2/100(2%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.63%   SD 1.19%     Total 16/500 (3.2%)    Mean 3.75%   SD 2.49%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)     8/100(8%)     1/50 (2%)          27/50 (54%)   53/100(53%)   36/50 (72%)    |
|                                        2/50 (4%)     2/50 (4%)     3/50 (6%)          15/50 (30%)   21/50 (42%)   15/50 (30%)    |
|                                        3/50 (6%)     3/100(3%)                        21/50 (42%)   55/100(55%)                  |
| Overall Incidence               Total 24/500 (4.8%)   Mean 4.63%   SD 1.92%     Total 243/500 (48.6%)  Mean 47.25%  SD 14.15%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     2/50 (4%)     9/100(9%)     1/50 (2%)          28/50 (56%)   53/100(53%)   36/50 (72%)    |
|                                        4/50 (8%)     2/50 (4%)     3/50 (6%)          15/50 (30%)   21/50 (42%)   16/50 (32%)    |
|                                        3/50 (6%)     3/100(3%)                        23/50 (46%)   55/100(55%)                  |
| Overall Incidence               Total 27/500 (5.4%)   Mean 5.25%   SD 2.43%     Total 247/500 (49.4%)  Mean 48.25%  SD 13.8%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    2/50 (4%)    11/100(11%)    1/50 (2%)          28/50 (56%)   53/100(53%)   37/50 (74%)    |
|      or Adenoma                        4/50 (8%)     2/50 (4%)     3/50 (6%)          16/50 (32%)   23/50 (46%)   16/50 (32%)    |
|                                        3/50 (6%)     3/100(3%)                        23/50 (46%)   56/100(56%)                  |
| Overall Incidence               Total 29/500 (5.8%)   Mean 5.5%    SD 2.93%     Total 252/500 (50.4%)  Mean 49.38%  SD 13.8%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 20
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 21
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     1/100(1%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 1/498 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/496 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.5%    SD 0.76%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.46%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     2/100(2%)     0/50 (0%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/100(2%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 5/500 (1%)      Mean 0.75%   SD 1.04%     Total 3/500 (0.6%)     Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.46%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 22
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/100(1%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 23
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     2/100(2%)     0/44 (0%)           0/50 (0%)     0/100(0%)     1/47 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 5/494 (1.01%)   Mean 0.88%   SD 1.46%     Total 2/497 (0.4%)     Mean 0.52%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/100(0%)     1/44 (2%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/494 (0.2%)    Mean 0.28%   SD 0.8%      Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     2/100(2%)     1/44 (2%)           0/50 (0%)     0/100(0%)     1/47 (2%)     |
|                                        0/50 (0%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 6/494 (1.21%)   Mean 1.16%   SD 1.48%     Total 2/497 (0.4%)     Mean 0.52%   SD 0.96%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)     1/100(1%)     0/44 (0%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/494 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   1/50 (2%)     0/100(0%)     2/44 (5%)           0/50 (0%)     0/100(0%)     0/47 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/494 (0.81%)   Mean 0.94%   SD 1.63%     Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/49 (0%)     0/93 (0%)     1/45 (2%)           0/47 (0%)     2/86 (2%)     0/49 (0%)     |
|                                        0/46 (0%)     0/46 (0%)     0/46 (0%)           1/46 (2%)     1/48 (2%)     0/45 (0%)     |
|                                        0/45 (0%)     0/92 (0%)                         0/46 (0%)     0/90 (0%)                   |
| Overall Incidence               Total 1/462 (0.22%)   Mean 0.28%   SD 0.79%     Total 4/457 (0.88%)    Mean 0.82%   SD 1.14%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 24
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      10/50 (20%)   17/100(17%)   15/47 (32%)         17/50 (34%)   29/100(29%)   20/48 (42%)    |
|   Adenoma                             19/50 (38%)   17/50 (34%)   11/50 (22%)         21/50 (42%)   12/50 (24%)   23/50 (46%)    |
|                                       13/50 (26%)   21/100(21%)                       24/50 (48%)   35/100(35%)                  |
| Overall Incidence               Total 123/497 (24.75%)Mean 26.24%  SD 7.56%     Total 181/498 (36.35%) Mean 37.46%  SD 8.39%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     1/48 (2%)     |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/497 (0.2%)    Mean 0.25%   SD 0.71%     Total 2/498 (0.4%)     Mean 0.51%   SD 0.95%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      10/50 (20%)   17/100(17%)   15/47 (32%)         17/50 (34%)   29/100(29%)   21/48 (44%)    |
|   Carcinoma or Adenoma                20/50 (40%)   17/50 (34%)   11/50 (22%)         21/50 (42%)   13/50 (26%)   23/50 (46%)    |
|                                       13/50 (26%)   21/100(21%)                       24/50 (48%)   35/100(35%)                  |
| Overall Incidence               Total 124/497 (24.95%)Mean 26.49%  SD 8.03%     Total 183/498 (36.75%) Mean 37.97%  SD 8.13%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     1/100(1%)     0/47 (0%)           0/50 (0%)     2/100(2%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.38%   SD 0.74%     Total 2/498 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/47 (0%)           0/50 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/497 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     0/47 (0%)           0/50 (0%)     2/100(2%)     0/48 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/497 (0.4%)    Mean 0.38%   SD 0.74%     Total 2/498 (0.4%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/100(0%)     1/48 (2%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     4/100(4%)                                                                   |
| Overall Incidence               Total 6/498 (1.2%)    Mean 1.01%   SD 1.52%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 25
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     1/48 (2%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     4/100(4%)                                                                   |
| Overall Incidence               Total 6/498 (1.2%)    Mean 1.01%   SD 1.52%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/49 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 1/498 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/49 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 1/498 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/49 (0%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/498 (0%)      Mean 0%      SD 0%        Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/49 (2%)     0/100(0%)     0/49 (0%)           0/50 (0%)     0/100(0%)     0/49 (0%)     |
|                                        1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/49 (0%)     0/100(0%)                   |
| Overall Incidence               Total 6/498 (1.2%)    Mean 1.51%   SD 1.77%     Total 0/498 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 26
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.75%   SD 0.89%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 27
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.75%   SD 0.89%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Tumor Benign, or                  1/50 (2%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)     2/100(2%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 7/500 (1.4%)    Mean 1.25%   SD 1.49%     Total 3/500 (0.6%)     Mean 0.75%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              1/50 (2%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       1/50 (2%)     0/50 (0%)     2/50 (4%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    1/50 (2%)     3/100(3%)                         2/50 (4%)     0/100(0%)                   |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 9/500 (1.8%)    Mean 1.63%   SD 1.51%     Total 4/500 (0.8%)     Mean 1%      SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        11/50 (22%)   11/100(11%)    1/50 (2%)           3/50 (6%)     1/100(1%)     0/50 (0%)     |
|      Carcinoma, Basosq. Tumor (M or    4/50 (8%)     2/50 (4%)     6/50 (12%)          1/50 (2%)     2/50 (4%)     0/50 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  3/50 (6%)     8/100(8%)                         3/50 (6%)     0/100(0%)                   |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 46/500 (9.2%)   Mean 9.13%   SD 6.17%     Total 10/500 (2%)      Mean 2.38%   SD 2.62%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 28
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                     10/50 (20%)    8/100(8%)     1/50 (2%)           3/50 (6%)     0/100(0%)     0/50 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)     5/100(5%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 32/500 (6.4%)   Mean 6.38%   SD 5.85%     Total 3/500 (0.6%)     Mean 0.75%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     0/100(0%)     1/50 (2%)           0/50 (0%)     2/100(2%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 5/500 (1%)      Mean 1.25%   SD 1.04%     Total 4/500 (0.8%)     Mean 0.75%   SD 1.04%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         1/50 (2%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 29
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      1/50 (2%)     1/100(1%)                         2/50 (4%)     0/100(0%)                   |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.63%   SD 0.92%     Total 2/500 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.88%   SD 0.99%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|      Papilloma                         1/50 (2%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.88%   SD 0.99%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/50 (22%)    9/100(9%)     1/50 (2%)           3/50 (6%)     1/100(1%)     0/50 (0%)     |
|      Papilloma, Squamous Cell          3/50 (6%)     2/50 (4%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma or Keratoacanthoma      2/50 (4%)     5/100(5%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 37/500 (7.4%)   Mean 7.5%    SD 6.28%     Total 6/500 (1.2%)     Mean 1.38%   SD 2.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/50 (22%)    9/100(9%)     1/50 (2%)           3/50 (6%)     1/100(1%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     3/50 (6%)     1/50 (2%)     4/50 (8%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)     5/100(5%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 36/500 (7.2%)   Mean 7.25%   SD 6.48%     Total 5/500 (1%)       Mean 1.13%   SD 2.1%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.5%    SD 0.76%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              5/50 (10%)    2/100(2%)     6/50 (12%)          3/50 (6%)     1/100(1%)     1/50 (2%)     |
|                                        1/50 (2%)     3/50 (6%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     7/100(7%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 26/500 (5.2%)   Mean 5.38%   SD 4.17%     Total 8/500 (1.6%)     Mean 1.75%   SD 1.91%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      6/50 (12%)    8/100(8%)     9/50 (18%)          4/50 (8%)     1/100(1%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous   3/50 (6%)     3/50 (6%)     4/50 (8%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Histiocytoma                      1/50 (2%)    12/100(12%)                        1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 46/500 (9.2%)   Mean 9%      SD 4.9%      Total 10/500 (2%)      Mean 2.25%   SD 2.43%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 30
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         0/50 (0%)     2/100(2%)     0/50 (0%)           1/50 (2%)     0/100(0%)     0/50 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     6/100(6%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 11/500 (2.2%)   Mean 1.75%   SD 2.25%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)     5/100(5%)     3/50 (6%)           1/50 (2%)     0/100(0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           2/50 (4%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Histiocytoma                      1/50 (2%)     6/100(6%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 20/500 (4%)     Mean 3.63%   SD 2.13%     Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 1/50 (2%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 4/500 (0.8%)    Mean 0.75%   SD 1.04%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or NOS)                           0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 31
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     1/100(1%)     3/50 (6%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 5/500 (1%)      Mean 1.13%   SD 2.1%      Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     2/100(2%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/100(0%)     0/43 (0%)           0/49 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/493 (0%)      Mean 0%      SD 0%        Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/100(0%)     0/43 (0%)           0/49 (0%)     0/100(0%)     0/48 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/493 (0%)      Mean 0%      SD 0%        Total 0/497 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     1/100(1%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.13%   SD 0.35%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 32
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     2/50 (4%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 2/500 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.38%   SD 0.74%     Total 2/500 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/500 (0.2%)    Mean 0.25%   SD 0.71%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 2/500 (0.4%)    Mean 0.5%    SD 0.93%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             45/50 (90%)   96/100(96%)   45/50 (90%)                                                    |
|                                       44/50 (88%)   40/50 (80%)   41/50 (82%)                                                    |
|                                       47/50 (94%)   91/100(91%)                                                                  |
| Overall Incidence               Total 449/500 (89.8%) Mean 88.88%  SD 5.49%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/100(0%)                                                                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 33
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/48 (0%)     0/97 (0%)     0/39 (0%)           0/50 (0%)     0/96 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/46 (0%)           0/45 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     0/87 (0%)                         0/49 (0%)     0/92 (0%)                   |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 0/474 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/48 (0%)     0/97 (0%)     0/39 (0%)           0/50 (0%)     0/96 (0%)     1/48 (2%)     |
|                                        0/45 (0%)     0/49 (0%)     0/46 (0%)           0/45 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     1/87 (1%)                         0/49 (0%)     0/92 (0%)                   |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.14%   SD 0.41%     Total 1/474 (0.21%)    Mean 0.26%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/48 (0%)     0/97 (0%)     0/39 (0%)           0/50 (0%)     0/96 (0%)     0/48 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/46 (0%)           0/45 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     0/87 (0%)                         0/49 (0%)     1/92 (1%)                   |
| Overall Incidence               Total 0/461 (0%)      Mean 0%      SD 0%        Total 1/474 (0.21%)    Mean 0.14%   SD 0.38%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/48 (0%)     0/97 (0%)     0/39 (0%)           0/50 (0%)     0/96 (0%)     1/48 (2%)     |
|                                        0/45 (0%)     0/49 (0%)     0/46 (0%)           0/45 (0%)     0/48 (0%)     0/46 (0%)     |
|                                        0/50 (0%)     1/87 (1%)                         0/49 (0%)     1/92 (1%)                   |
| Overall Incidence               Total 1/461 (0.22%)   Mean 0.14%   SD 0.41%     Total 2/474 (0.42%)    Mean 0.4%    SD 0.78%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             10/50 (20%)   12/100(12%)    4/42 (10%)          4/50 (8%)    21/100(21%)    6/45 (13%)    |
|                                        8/50 (16%)    9/50 (18%)    8/50 (16%)         11/50 (22%)    3/50 (6%)     5/50 (10%)    |
|                                       12/50 (24%)   12/100(12%)                        7/50 (14%)   11/100(11%)                  |
| Overall Incidence               Total 75/492 (15.24%) Mean 15.94%  SD 4.75%     Total 68/495 (13.74%)  Mean 13.17%  SD 5.77%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)     4/100(4%)     2/42 (5%)           0/50 (0%)     0/100(0%)     1/45 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     2/50 (4%)     |
|                                        2/50 (4%)     3/100(3%)                         2/50 (4%)     3/100(3%)                   |
| Overall Incidence               Total 15/492 (3.05%)  Mean 2.97%   SD 1.56%     Total 10/495 (2.02%)   Mean 2.15%   SD 1.88%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                11/50 (22%)   16/100(16%)    6/42 (14%)          4/50 (8%)    21/100(21%)    7/45 (16%)    |
|                                       10/50 (20%)   10/50 (20%)    8/50 (16%)         11/50 (22%)    5/50 (10%)    7/50 (14%)    |
|                                       14/50 (28%)   15/100(15%)                        9/50 (18%)   14/100(14%)                  |
| Overall Incidence               Total 90/492 (18.29%) Mean 18.91%  SD 4.6%      Total 78/495 (15.76%)  Mean 15.32%  SD 4.92%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              2/50 (4%)     3/100(3%)     1/42 (2%)           0/50 (0%)     0/100(0%)     0/45 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     1/100(1%)                         1/50 (2%)     1/100(1%)                   |
| Overall Incidence               Total 9/492 (1.83%)   Mean 1.8%    SD 1.4%      Total 3/495 (0.61%)    Mean 0.63%   SD 0.92%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 34
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     1/100(1%)     0/42 (0%)           0/50 (0%)     1/100(1%)     1/45 (2%)     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)     3/100(3%)                         1/50 (2%)     0/100(0%)                   |
| Overall Incidence               Total 7/492 (1.42%)   Mean 1.25%   SD 1.58%     Total 5/495 (1.01%)    Mean 1.15%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     4/100(4%)     1/42 (2%)           0/50 (0%)     1/100(1%)     1/45 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        2/50 (4%)     4/100(4%)                         2/50 (4%)     1/100(1%)                   |
| Overall Incidence               Total 16/492 (3.25%)  Mean 3.05%   SD 1.48%     Total 8/495 (1.62%)    Mean 1.78%   SD 1.17%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 35
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     1/50 (2%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.5%    SD 0.76%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              1/50 (2%)     1/100(1%)     0/50 (0%)           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/100(1%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 3/500 (0.6%)    Mean 0.5%    SD 0.76%     Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/495 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/49 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/495 (0.2%)    Mean 0.26%   SD 0.72%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 0/495 (0%)      Mean 0%      SD 0%        Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/100(0%)     0/46 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/49 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/495 (0.2%)    Mean 0.26%   SD 0.72%     Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 36
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/100(0%)     1/46 (2%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 1/495 (0.2%)    Mean 0.27%   SD 0.77%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     1/100(1%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/50 (4%)     0/100(0%)                   |
| Overall Incidence                                                               Total 2/500 (0.4%)     Mean 0.5%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     1/100(1%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.13%   SD 0.35%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        6/50 (12%)   19/100(19%)    8/50 (16%)    |
|                                                                                        7/50 (14%)    7/50 (14%)   10/50 (20%)    |
|                                                                                        7/50 (14%)   14/100(14%)                  |
| Overall Incidence                                                               Total 78/500 (15.6%)   Mean 15.38%  SD 2.77%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 1/500 (0.2%)     Mean 0.25%   SD 0.71%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 37
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/100(0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 2/500 (0.4%)     Mean 0.5%    SD 0.93%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     6/50 (12%)   19/100(19%)    9/50 (18%)    |
|                                                                                        7/50 (14%)    7/50 (14%)   11/50 (22%)    |
|                                                                                        7/50 (14%)   14/100(14%)                  |
| Overall Incidence                                                               Total 80/500 (16%)     Mean 15.88%  SD 3.4%      |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/100(0%)                   |
| Overall Incidence                                                               Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/100(0%)     0/50 (0%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 0/500 (0%)      Mean 0%      SD 0%        Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     1/100(1%)     3/50 (6%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     0/100(0%)                   |
| Overall Incidence               Total 6/500 (1.2%)    Mean 1.38%   SD 2.07%     Total 0/500 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 38
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE COLUMBUS                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     1/100(1%)     3/50 (6%)           0/50 (0%)     0/100(0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/100(0%)                         0/50 (0%)     1/100(1%)                   |
| Overall Incidence               Total 6/500 (1.2%)    Mean 1.38%   SD 2.07%     Total 2/500 (0.4%)     Mean 0.38%   SD 0.74%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 39
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       47/50 (94%)   49/50 (98%)   47/50 (94%)         46/50 (92%)   43/50 (86%)   44/50 (88%)    |
|                                       46/49 (94%)   50/50 (100%)  50/50 (100%)        38/49 (78%)   41/50 (82%)   37/50 (74%)    |
|                                       48/50 (96%)                                     41/50 (82%)                                |
| Overall Incidence               Total 337/349 (96.56%)Mean 96.55%  SD 2.78%     Total 290/349 (83.09%) Mean 83.08%  SD 6.16%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    27/50 (54%)   29/50 (58%)   26/50 (52%)         25/50 (50%)   17/50 (34%)   25/50 (50%)    |
|                                       34/49 (69%)   35/50 (70%)   33/50 (66%)         26/49 (53%)   33/50 (66%)   30/50 (60%)    |
|                                       28/50 (56%)                                     28/50 (56%)                                |
| Overall Incidence               Total 212/349 (60.74%)Mean 60.77%  SD 7.53%     Total 184/349 (52.72%) Mean 52.72%  SD 10.05%    |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         49/50 (98%)   50/50 (100%)  49/50 (98%)         49/50 (98%)   46/50 (92%)   49/50 (98%)    |
|                                       48/49 (98%)   50/50 (100%)  50/50 (100%)        44/49 (90%)   49/50 (98%)   44/50 (88%)    |
|                                       50/50 (100%)                                    47/50 (94%)                                |
| Overall Incidence               Total 346/349 (99.14%)Mean 99.14%  SD 1.08%     Total 328/349 (93.98%) Mean 93.97%  SD 4.2%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 2/349 (0.57%)    Mean 0.58%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           2/49 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 3/349 (0.86%)    Mean 0.87%   SD 1.6%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 3/349 (0.86%)    Mean 0.86%   SD 1.57%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   19/50 (38%)   22/50 (44%)   16/50 (32%)         11/50 (22%)   10/50 (20%)   14/50 (28%)    |
|      Mononuclear, or Undifferentiated 26/49 (53%)   33/50 (66%)   25/50 (50%)         16/49 (33%)   24/50 (48%)   26/50 (52%)    |
|                                       22/50 (44%)                                     21/50 (42%)                                |
| Overall Incidence               Total 163/349 (46.7%) Mean 46.72%  SD 11.03%    Total 122/349 (34.96%) Mean 34.95%  SD 12.62%    |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 40
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Undifferentiated Cell Type        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/349 (0.57%)   Mean 0.58%   SD 1.54%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               2/49 (4%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 10/349 (2.87%)  Mean 2.87%   SD 1.58%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     2/50 (4%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/349 (2.29%)   Mean 2.29%   SD 1.8%      Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 9/349 (2.58%)   Mean 2.58%   SD 1.9%      Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 9/349 (2.58%)   Mean 2.58%   SD 1.9%      Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        2/49 (4%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     2/49 (4%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/349 (0.57%)   Mean 0.58%   SD 1.54%     Total 4/346 (1.16%)    Mean 1.17%   SD 1.61%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 41
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 2/346 (0.58%)    Mean 0.58%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/49 (14%)   12/50 (24%)   10/50 (20%)          1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|                                        4/49 (8%)    12/50 (24%)    5/50 (10%)          3/48 (6%)     2/49 (4%)     2/50 (4%)     |
|                                        4/50 (8%)                                       2/49 (4%)                                 |
| Overall Incidence               Total 54/348 (15.52%) Mean 15.49%  SD 7.15%     Total 14/346 (4.05%)   Mean 4.06%   SD 1.23%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/49 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     2/50 (4%)     1/50 (2%)           0/48 (0%)     0/49 (0%)     1/50 (2%)     |
|                                        1/50 (2%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 8/348 (2.3%)    Mean 2.3%    SD 1.4%      Total 1/346 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            8/49 (16%)   13/50 (26%)   10/50 (20%)          1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|      Complex, Malignant, NOS           5/49 (10%)   14/50 (28%)    6/50 (12%)          3/48 (6%)     2/49 (4%)     3/50 (6%)     |
|                                        5/50 (10%)                                      2/49 (4%)                                 |
| Overall Incidence               Total 61/348 (17.53%) Mean 17.5%   SD 7.41%     Total 15/346 (4.34%)   Mean 4.34%   SD 1.43%     |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 42
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 9/349 (2.58%)   Mean 2.58%   SD 1.9%      Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     1/50 (2%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 9/349 (2.58%)   Mean 2.58%   SD 1.9%      Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/348 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 43
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 1/347 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Astrocytoma                       0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/348 (0.29%)   Mean 0.29%   SD 0.76%     Total 1/347 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)     0/48 (0%)     1/50 (2%)           8/48 (17%)    0/50 (0%)     5/49 (10%)    |
|                                        3/48 (6%)     1/50 (2%)     0/50 (0%)           4/49 (8%)     1/50 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 5/346 (1.45%)   Mean 1.46%   SD 2.31%     Total 20/345 (5.8%)    Mean 5.86%   SD 6.16%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/48 (0%)     2/50 (4%)           1/48 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        3/48 (6%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     2/50 (4%)     1/49 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/346 (1.73%)   Mean 1.75%   SD 2.5%      Total 4/345 (1.16%)    Mean 1.16%   SD 1.59%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/48 (0%)     3/50 (6%)           9/48 (19%)    0/50 (0%)     5/49 (10%)    |
|                                        6/48 (13%)    2/50 (4%)     0/50 (0%)           4/49 (8%)     3/50 (6%)     1/49 (2%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 11/346 (3.18%)  Mean 3.21%   SD 4.76%     Total 24/345 (6.96%)   Mean 7.02%   SD 6.24%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)     0/48 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/346 (0%)      Mean 0%      SD 0%        Total 0/345 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 44
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/346 (0%)      Mean 0%      SD 0%        Total 0/345 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)     0/48 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/346 (0%)      Mean 0%      SD 0%        Total 0/345 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)     0/48 (0%)     0/50 (0%)           0/48 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/346 (0%)      Mean 0%      SD 0%        Total 0/345 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Amelanotic Melanoma, Benign          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 45
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/348 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/348 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 46
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 47
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)     5/50 (10%)    1/50 (2%)           1/50 (2%)     1/50 (2%)     1/50 (2%)     |
|                                        2/49 (4%)     4/50 (8%)     3/50 (6%)           1/49 (2%)     0/49 (0%)     1/49 (2%)     |
|                                        1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 19/349 (5.44%)  Mean 5.44%   SD 2.99%     Total 6/346 (1.73%)    Mean 1.73%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            4/50 (8%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        4/49 (8%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     1/49 (2%)     0/49 (0%)     |
|                                        1/50 (2%)                                       1/49 (2%)                                 |
| Overall Incidence               Total 13/349 (3.72%)  Mean 3.74%   SD 3.18%     Total 4/346 (1.16%)    Mean 1.16%   SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 7/50 (14%)    6/50 (12%)    3/50 (6%)           2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        6/49 (12%)    4/50 (8%)     4/50 (8%)           2/49 (4%)     1/49 (2%)     1/49 (2%)     |
|                                        2/50 (4%)                                       2/49 (4%)                                 |
| Overall Incidence               Total 32/349 (9.17%)  Mean 9.18%   SD 3.66%     Total 10/346 (2.89%)   Mean 2.89%   SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            1/49 (2%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/349 (0.86%)   Mean 0.86%   SD 1.08%     Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma or Adenoma                 1/49 (2%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/349 (0.86%)   Mean 0.86%   SD 1.08%     Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Papilloma                            0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/349 (0.86%)   Mean 0.86%   SD 1.07%     Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 48
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           1/48 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 1/346 (0.29%)    Mean 0.3%    SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     1/50 (2%)           1/48 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 4/349 (1.15%)   Mean 1.14%   SD 1.07%     Total 1/346 (0.29%)    Mean 0.3%    SD 0.79%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/346 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 49
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     3/50 (6%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 4/349 (1.15%)   Mean 1.15%   SD 2.27%     Total 2/347 (0.58%)    Mean 0.58%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.77%     Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    1/49 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.77%     Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatocellular Adenoma            2/49 (4%)     3/50 (6%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     0/49 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 5/349 (1.43%)   Mean 1.44%   SD 2.52%     Total 2/347 (0.58%)    Mean 0.58%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        2/49 (4%)     3/50 (6%)     0/50 (0%)           0/49 (0%)     1/49 (2%)     0/49 (0%)     |
|      Hepatoblastoma                    0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 5/349 (1.43%)   Mean 1.44%   SD 2.52%     Total 2/347 (0.58%)    Mean 0.58%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)     0/50 (0%)     6/50 (12%)          1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     0/50 (0%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        4/50 (8%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 14/349 (4.01%)  Mean 4.01%   SD 4.47%     Total 2/347 (0.58%)    Mean 0.58%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       1/50 (2%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 5/349 (1.43%)   Mean 1.43%   SD 0.98%     Total 2/347 (0.58%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 50
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    2/50 (4%)     1/50 (2%)     7/50 (14%)          2/50 (4%)     0/50 (0%)     1/50 (2%)     |
|      Alveolar/Bronchiolar Adenoma      2/49 (4%)     1/50 (2%)     2/50 (4%)           1/49 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        4/50 (8%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 19/349 (5.44%)  Mean 5.44%   SD 4.27%     Total 4/347 (1.15%)    Mean 1.15%   SD 1.58%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 51
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            1/50 (2%)     1/50 (2%)     0/50 (0%)           5/50 (10%)    3/50 (6%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/50 (0%)           3/49 (6%)     5/50 (10%)    4/50 (8%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 3/349 (0.86%)   Mean 0.86%   SD 1.08%     Total 22/349 (6.3%)    Mean 6.3%    SD 3.54%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     1/50 (2%)     0/50 (0%)           5/50 (10%)    3/50 (6%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/50 (0%)           3/49 (6%)     5/50 (10%)    4/50 (8%)     |
|                                        0/50 (0%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 4/349 (1.15%)   Mean 1.15%   SD 1.58%     Total 23/349 (6.59%)   Mean 6.59%   SD 3.41%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)     1/50 (2%)     2/50 (4%)          25/50 (50%)   20/50 (40%)   20/50 (40%)    |
|                                        0/49 (0%)     2/50 (4%)     3/50 (6%)          17/49 (35%)   25/50 (50%)   19/50 (38%)    |
|                                        2/50 (4%)                                      16/50 (32%)                                |
| Overall Incidence               Total 12/349 (3.44%)  Mean 3.43%   SD 1.9%      Total 142/349 (40.69%) Mean 40.67%  SD 6.99%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     1/50 (2%)     2/50 (4%)          25/50 (50%)   20/50 (40%)   20/50 (40%)    |
|                                        0/49 (0%)     2/50 (4%)     3/50 (6%)          17/49 (35%)   25/50 (50%)   19/50 (38%)    |
|                                        2/50 (4%)                                      17/50 (34%)                                |
| Overall Incidence               Total 13/349 (3.72%)  Mean 3.71%   SD 2.14%     Total 143/349 (40.97%) Mean 40.96%  SD 6.6%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    4/50 (8%)     1/50 (2%)     2/50 (4%)          29/50 (58%)   22/50 (44%)   20/50 (40%)    |
|      or Adenoma                        1/49 (2%)     2/50 (4%)     3/50 (6%)          18/49 (37%)   27/50 (54%)   23/50 (46%)    |
|                                        2/50 (4%)                                      19/50 (38%)                                |
| Overall Incidence               Total 15/349 (4.3%)   Mean 4.29%   SD 2.13%     Total 158/349 (45.27%) Mean 45.25%  SD 8.1%      |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 52
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.77%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 53
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/347 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/347 (0.29%)   Mean 0.29%   SD 0.76%     Total 1/347 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/347 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/347 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/349 (0.57%)   Mean 0.57%   SD 0.98%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 2/349 (0.57%)    Mean 0.57%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/50 (0%)     1/50 (2%)     1/50 (2%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/349 (0.57%)   Mean 0.57%   SD 0.98%     Total 3/349 (0.86%)    Mean 0.86%   SD 2.27%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 54
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        2/49 (4%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/349 (0.57%)    Mean 0.58%   SD 1.54%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Malignant, NOS                                                                    2/49 (4%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/349 (0.86%)    Mean 0.87%   SD 1.6%      |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/49 (2%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 3/349 (0.86%)    Mean 0.86%   SD 1.08%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 55
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/349 (0.57%)   Mean 0.58%   SD 0.99%     Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/349 (0.57%)   Mean 0.58%   SD 0.99%     Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/49 (0%)     0/46 (0%)     1/44 (2%)           0/49 (0%)     0/49 (0%)     0/40 (0%)     |
|                                        0/45 (0%)     0/49 (0%)     0/50 (0%)           0/42 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/45 (0%)                                 |
| Overall Incidence               Total 1/332 (0.3%)    Mean 0.32%   SD 0.86%     Total 0/323 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 56
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      27/50 (54%)   36/50 (72%)   36/49 (73%)         34/50 (68%)   37/50 (74%)   30/50 (60%)    |
|   Adenoma                             31/49 (63%)   35/50 (70%)   38/50 (76%)         23/49 (47%)   30/49 (61%)   27/49 (55%)    |
|                                       35/50 (70%)                                     31/49 (63%)                                |
| Overall Incidence               Total 238/348 (68.39%)Mean 68.39%  SD 7.48%     Total 212/346 (61.27%) Mean 61.22%  SD 8.72%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/50 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|   Carcinoma                            0/49 (0%)     0/50 (0%)     1/50 (2%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 2/348 (0.57%)   Mean 0.58%   SD 0.99%     Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      27/50 (54%)   36/50 (72%)   37/49 (76%)         34/50 (68%)   37/50 (74%)   30/50 (60%)    |
|   Carcinoma or Adenoma                31/49 (63%)   35/50 (70%)   39/50 (78%)         23/49 (47%)   30/49 (61%)   27/49 (55%)    |
|                                       35/50 (70%)                                     31/49 (63%)                                |
| Overall Incidence               Total 240/348 (68.97%)Mean 68.97%  SD 8.09%     Total 212/346 (61.27%) Mean 61.22%  SD 8.72%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/346 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 57
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/50 (2%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/348 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/348 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/348 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/348 (0%)      Mean 0%      SD 0%        Total 0/348 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 58
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     3/50 (6%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/349 (1.72%)   Mean 1.72%   SD 2.14%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/49 (2%)     1/50 (2%)     3/50 (6%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 6/349 (1.72%)   Mean 1.72%   SD 2.14%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 59
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor Benign, or                  0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Trichoepithelioma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 2/349 (0.57%)   Mean 0.57%   SD 0.98%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      NOS)                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Adenoma, Basosquamous Tumor       0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      (benign, malignant or NOS), or    0/50 (0%)                                       0/50 (0%)                                 |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 2/349 (0.57%)   Mean 0.57%   SD 0.98%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         3/50 (6%)     2/50 (4%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma, Basosq. Tumor (M or    4/49 (8%)     2/50 (4%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     1/50 (2%)     |
|      B), Basal Cell Adenoma, Adenoma,  5/50 (10%)                                      0/50 (0%)                                 |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 19/349 (5.44%)  Mean 5.45%   SD 2.79%     Total 4/349 (1.15%)    Mean 1.15%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 60
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        4/49 (8%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        4/50 (8%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 12/349 (3.44%)  Mean 3.45%   SD 3.45%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/49 (2%)     1/50 (2%)     2/50 (4%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/349 (2.29%)   Mean 2.29%   SD 1.38%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 61
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Cell Carcinoma, Basosquamous      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 2/349 (0.57%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/349 (1.43%)   Mean 1.43%   SD 0.98%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma                         0/49 (0%)     1/50 (2%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 5/349 (1.43%)   Mean 1.43%   SD 0.98%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma, Squamous Cell          4/49 (8%)     2/50 (4%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     1/50 (2%)     |
|      Carcinoma or Keratoacanthoma      5/50 (10%)                                      0/50 (0%)                                 |
| Overall Incidence               Total 17/349 (4.87%)  Mean 4.88%   SD 3.05%     Total 3/349 (0.86%)    Mean 0.86%   SD 1.08%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             2/50 (4%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma, or Keratoacanthoma     4/49 (8%)     2/50 (4%)     1/50 (2%)           1/49 (2%)     0/50 (0%)     1/50 (2%)     |
|                                        5/50 (10%)                                      0/50 (0%)                                 |
| Overall Incidence               Total 17/349 (4.87%)  Mean 4.88%   SD 3.05%     Total 2/349 (0.57%)    Mean 0.58%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              2/50 (4%)     5/50 (10%)    1/50 (2%)           0/50 (0%)     0/50 (0%)     3/50 (6%)     |
|                                        5/49 (10%)    2/50 (4%)     2/50 (4%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 19/349 (5.44%)  Mean 5.46%   SD 3.26%     Total 5/349 (1.43%)    Mean 1.43%   SD 2.23%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      4/50 (8%)     6/50 (12%)    2/50 (4%)           2/50 (4%)     0/50 (0%)     3/50 (6%)     |
|      Myxoma, Myxosarcoma, or Fibrous   7/49 (14%)    3/50 (6%)     3/50 (6%)           1/49 (2%)     3/50 (6%)     0/50 (0%)     |
|      Histiocytoma                      6/50 (12%)                                      1/50 (2%)                                 |
| Overall Incidence               Total 31/349 (8.88%)  Mean 8.9%    SD 3.87%     Total 10/349 (2.87%)   Mean 2.86%   SD 2.54%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 62
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        2/49 (4%)     1/50 (2%)     1/50 (2%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 8/349 (2.29%)   Mean 2.3%    SD 1.4%      Total 2/349 (0.57%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               2/50 (4%)     1/50 (2%)     1/50 (2%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           2/49 (4%)     1/50 (2%)     1/50 (2%)           1/49 (2%)     2/50 (4%)     0/50 (0%)     |
|      Histiocytoma                      4/50 (8%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 12/349 (3.44%)  Mean 3.44%   SD 2.23%     Total 5/349 (1.43%)    Mean 1.43%   SD 1.9%      |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        2/50 (4%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 3/349 (0.86%)   Mean 0.86%   SD 1.57%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|      or NOS)                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 63
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 2/349 (0.57%)    Mean 0.58%   SD 0.99%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/347 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           1/49 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/347 (0.29%)    Mean 0.29%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 64
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             40/50 (80%)   38/50 (76%)   40/50 (80%)                                                    |
|                                       38/49 (78%)   41/50 (82%)   41/50 (82%)                                                    |
|                                       36/50 (72%)                                                                                |
| Overall Incidence               Total 274/349 (78.51%)Mean 78.51%  SD 3.61%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)                                                                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 65
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/47 (0%)     0/47 (0%)     0/49 (0%)           0/46 (0%)     0/45 (0%)     0/47 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/325 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)     0/48 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/47 (0%)     0/47 (0%)     0/49 (0%)           0/46 (0%)     0/45 (0%)     0/47 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 0/337 (0%)      Mean 0%      SD 0%        Total 0/325 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)     0/48 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/47 (0%)     0/47 (0%)     1/49 (2%)           0/46 (0%)     0/45 (0%)     0/47 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/337 (0.3%)    Mean 0.29%   SD 0.77%     Total 0/325 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)     0/48 (0%)     0/47 (0%)           0/48 (0%)     0/45 (0%)     0/45 (0%)     |
|                                        0/47 (0%)     0/47 (0%)     1/49 (2%)           0/46 (0%)     0/45 (0%)     0/47 (0%)     |
|                                        0/49 (0%)                                       0/49 (0%)                                 |
| Overall Incidence               Total 1/337 (0.3%)    Mean 0.29%   SD 0.77%     Total 0/325 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              7/50 (14%)    2/50 (4%)     5/49 (10%)          5/50 (10%)    0/50 (0%)     6/47 (13%)    |
|                                        9/46 (20%)    3/50 (6%)     7/50 (14%)          4/47 (9%)     8/49 (16%)    3/49 (6%)     |
|                                        1/50 (2%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 34/345 (9.86%)  Mean 9.97%   SD 6.32%     Total 28/342 (8.19%)   Mean 8.25%   SD 5.47%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            0/50 (0%)     1/50 (2%)     1/49 (2%)           3/50 (6%)     1/50 (2%)     3/47 (6%)     |
|                                        1/46 (2%)     1/50 (2%)     2/50 (4%)           3/47 (6%)     2/49 (4%)     1/49 (2%)     |
|                                        0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 6/345 (1.74%)   Mean 1.74%   SD 1.39%     Total 14/342 (4.09%)   Mean 4.13%   SD 2.12%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 7/50 (14%)    3/50 (6%)     6/49 (12%)          8/50 (16%)    1/50 (2%)     8/47 (17%)    |
|                                       10/46 (22%)    4/50 (8%)     9/50 (18%)          7/47 (15%)    9/49 (18%)    4/49 (8%)     |
|                                        1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence               Total 40/345 (11.59%) Mean 11.71%  SD 6.91%     Total 40/342 (11.7%)   Mean 11.78%  SD 6.33%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
|                                        0/46 (0%)     0/50 (0%)     0/50 (0%)           0/47 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/345 (0.29%)   Mean 0.29%   SD 0.76%     Total 0/342 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 66
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/47 (2%)     |
|                                        0/46 (0%)     1/50 (2%)     1/50 (2%)           1/47 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 2/345 (0.58%)   Mean 0.57%   SD 0.98%     Total 4/342 (1.17%)    Mean 1.18%   SD 1.6%      |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     1/47 (2%)     |
|                                        0/46 (0%)     1/50 (2%)     1/50 (2%)           1/47 (2%)     0/49 (0%)     0/49 (0%)     |
|                                        0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence               Total 3/345 (0.87%)   Mean 0.86%   SD 1.07%     Total 4/342 (1.17%)    Mean 1.18%   SD 1.6%      |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 67
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 2/349 (0.57%)    Mean 0.57%   SD 1.51%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 0/347 (0%)      Mean 0%      SD 0%        Total 1/345 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)     0/50 (0%)     0/50 (0%)           1/48 (2%)     0/49 (0%)     1/49 (2%)     |
|                                        0/49 (0%)                                       1/50 (2%)                                 |
| Overall Incidence               Total 1/347 (0.29%)   Mean 0.3%    SD 0.79%     Total 3/345 (0.87%)    Mean 0.87%   SD 1.09%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     1/49 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/347 (0%)      Mean 0%      SD 0%        Total 1/345 (0.29%)    Mean 0.29%   SD 0.77%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        1/48 (2%)     0/50 (0%)     0/50 (0%)           1/48 (2%)     0/49 (0%)     1/49 (2%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/347 (0.29%)   Mean 0.3%    SD 0.79%     Total 2/345 (0.58%)    Mean 0.59%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 68
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/50 (0%)           0/48 (0%)     0/49 (0%)     0/49 (0%)     |
|                                        0/49 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/347 (0%)      Mean 0%      SD 0%        Total 0/345 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                        7/50 (14%)    9/50 (18%)   10/50 (20%)    |
|                                                                                       15/49 (31%)    5/50 (10%)   10/50 (20%)    |
|                                                                                        6/50 (12%)                                |
| Overall Incidence                                                               Total 62/349 (17.77%)  Mean 17.8%   SD 6.87%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 69
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                     7/50 (14%)    9/50 (18%)   10/50 (20%)    |
|                                                                                       15/49 (31%)    5/50 (10%)   11/50 (22%)    |
|                                                                                        6/50 (12%)                                |
| Overall Incidence                                                               Total 63/349 (18.05%)  Mean 18.09%  SD 7.01%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 1/349 (0.29%)    Mean 0.29%   SD 0.76%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/49 (0%)     1/50 (2%)     0/50 (0%)     |
|                                                                                        0/50 (0%)                                 |
| Overall Incidence                                                               Total 2/349 (0.57%)    Mean 0.57%   SD 0.98%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/50 (0%)           0/49 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 0/349 (0%)      Mean 0%      SD 0%        Total 0/349 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/49 (0%)     1/50 (2%)     0/50 (0%)           2/49 (4%)     2/50 (4%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 7/349 (2.01%)    Mean 2.01%   SD 1.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 70
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE NORTHWEST                        Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|                                        0/49 (0%)     1/50 (2%)     0/50 (0%)           2/49 (4%)     2/50 (4%)     1/50 (2%)     |
|                                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence               Total 1/349 (0.29%)   Mean 0.29%   SD 0.76%     Total 7/349 (2.01%)    Mean 2.01%   SD 1.65%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 71
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       50/50 (100%)                                    44/50 (88%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    31/50 (62%)                                     22/50 (44%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)                                    46/50 (92%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/50 (0%)                                       2/50 (4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   25/50 (50%)                                     14/50 (28%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)                                       0/50 (0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     1/50 (2%)                                       0/50 (0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 72
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              8/50 (16%)                                      3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            8/50 (16%)                                      3/50 (6%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 73
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)                                       0/50 (0%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 74
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Amelanotic Melanoma, Benign          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 75
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 76
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/50 (6%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            4/50 (8%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 7/50 (14%)                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)                                       0/50 (0%)                                 |
|   Papilloma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 77
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)                                       0/50 (0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/50 (2%)                                       0/50 (0%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/50 (2%)                                       0/50 (0%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 78
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    0/50 (0%)                                       1/50 (2%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            2/50 (4%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)                                       5/50 (10%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         2/50 (4%)                                      22/50 (44%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 79
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     2/50 (4%)                                      22/50 (44%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    4/50 (8%)                                      26/50 (52%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 80
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)                                       0/50 (0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 81
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/49 (0%)                                       0/46 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      35/50 (70%)                                     24/49 (49%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 82
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)                                       0/49 (0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      35/50 (70%)                                     24/49 (49%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/49 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 83
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     0/50 (0%)                                       0/50 (0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 84
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)                                       0/50 (0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     0/50 (0%)                                       0/50 (0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         0/50 (0%)                                       0/50 (0%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 85
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)                                       0/50 (0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              4/50 (8%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 86
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      5/50 (10%)                                      0/50 (0%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/50 (2%)                                       0/50 (0%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)                                       0/50 (0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)                                       0/50 (0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 87
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             42/50 (84%)                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 88
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/49 (0%)                                       0/47 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              1/50 (2%)                                       3/50 (6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            2/50 (4%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 3/50 (6%)                                       4/50 (8%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)                                       1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 89
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)                                       0/50 (0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 90
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       12/50 (24%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    13/50 (26%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              1/50 (2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 91
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: BATTELLE TOXICOLOGY NORTHWEST             Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/50 (0%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/50 (2%)                                       0/50 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 93
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       99/100(99%)                                     92/100(92%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    66/100(66%)                                     40/100(40%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors        100/100(100%)                                    98/100(98%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   50/100(50%)                                     20/100(20%)                                |
|      Mononuclear, or Undifferentiated                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/100(0%)                                       0/100(0%)                                 |
|      Lymphocytic, Mixed, NOS, or                                                                                                 |
|      Undifferentiated Cell Type                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/100(4%)                                       0/100(0%)                                 |
|      NOS                                                                                                                         |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/100(4%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 94
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              0/99 (0%)                                       6/100(6%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/99 (0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign             24/98 (24%)                                      7/96 (7%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/98 (0%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           2/98 (2%)                                       0/96 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,           26/98 (27%)                                      7/96 (7%)                                 |
|      Complex, Malignant, NOS                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 95
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        2/100(2%)                                       2/100(2%)                                 |
|      Astrocytoma                                                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                             13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 96
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                13/100(13%)                                     11/90 (12%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/100(0%)                                       0/90 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Amelanotic Melanoma, Benign          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 97
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 2/100(2%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 98
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              3/99 (3%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            1/99 (1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/99 (4%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/100(0%)                                       0/100(0%)                                 |
|   Papilloma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 99
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/100(0%)                                       0/100(0%)                                 |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            1/100(1%)                                       0/100(0%)                                 |
|      Hepatocellular Adenoma, or                                                                                                  |
|      Hepatoblastoma                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         3/100(3%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 100
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    3/100(3%)                                       4/100(4%)                                 |
|      Alveolar/Bronchiolar Adenoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            0/100(0%)                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 0/100(0%)                                       3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 101
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     6/100(6%)                                      56/100(56%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    6/100(6%)                                      58/100(58%)                                |
|      or Adenoma                                                                                                                  |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Rhabdomyosarcoma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 102
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous, or Papilloma                                                                                            |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/100(0%)                                 |
|      Malignant, NOS                                                                                                              |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 103
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                              3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                 3/98 (3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/98 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/85 (0%)                                       1/88 (1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     61/99 (62%)                                |
|   Adenoma                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 104
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/98 (0%)                                       3/99 (3%)                                 |
|   Carcinoma                                                                                                                      |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      34/98 (35%)                                     64/99 (65%)                                |
|   Carcinoma or Adenoma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/98 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 0/100(0%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 105
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   3/100(3%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                3/100(3%)                                       0/100(0%)                                 |
|      Basosquamous Tumor Benign                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     3/100(3%)                                       0/100(0%)                                 |
|      Tumor Benign, or                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 106
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/100(0%)                                       0/100(0%)                                 |
|      Basosquamous Tumor (malignant or                                                                                            |
|      NOS)                                                                                                                        |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     3/100(3%)                                       0/100(0%)                                 |
|      Adenoma, Basosquamous Tumor                                                                                                 |
|      (benign, malignant or NOS), or                                                                                              |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,        14/100(14%)                                      1/100(1%)                                 |
|      Carcinoma, Basosq. Tumor (M or                                                                                              |
|      B), Basal Cell Adenoma, Adenoma,                                                                                            |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                     10/100(10%)                                      1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 107
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/100(0%)                                       0/100(0%)                                 |
|      Cell Carcinoma, Basosquamous                                                                                                |
|      Tumor (malignant or NOS), or                                                                                                |
|      Carcinoma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma                                                                                                                   |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, Squamous Cell                                                                                                    |
|      Carcinoma or Keratoacanthoma                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,            11/100(11%)                                      1/100(1%)                                 |
|      Papilloma, or Keratoacanthoma                                                                                               |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                             12/100(12%)                                      4/100(4%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 108
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,     13/100(13%)                                      6/100(6%)                                 |
|      Myxoma, Myxosarcoma, or Fibrous                                                                                             |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         1/100(1%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               1/100(1%)                                       2/100(2%)                                 |
|      Myxosarcoma, or Fibrous                                                                                                     |
|      Histiocytoma                                                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/100(0%)                                       0/100(0%)                                 |
|      (malignant or NOS)                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/100(0%)                                       0/100(0%)                                 |
|      or Schwannoma (benign, malignant                                                                                            |
|      or NOS)                                                                                                                     |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/100(0%)                                       1/100(1%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 109
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           1/100(1%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             93/100(93%)                                                                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 110
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            1/100(1%)                                                                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/97 (0%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      2/97 (2%)                                       0/95 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                             15/99 (15%)                                     15/100(15%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/99 (1%)                                       5/100(5%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                16/99 (16%)                                     19/100(19%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            0/99 (0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/99 (1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 111
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/100(0%)                                       0/100(0%)                                 |
|      Papilloma Squamous                                                                                                          |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            1/99 (1%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/99 (0%)                                       0/99 (0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 112
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       2/100(2%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    13/100(13%)                                |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 3/100(3%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 113
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: IITRI                                     Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              0/100(0%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 1/100(1%)                                       0/100(0%)                                 |
| Overall Incidence                                                                                                                |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied

























                                                                                  

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                                                 Toxicology Data Management System                                     Page: 115
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Benign Tumors                       48/50 (96%)   49/50 (98%)   50/50 (100%)        45/50 (90%)   43/50 (86%)   48/50 (96%)    |
|                                       48/50 (96%)   47/50 (94%)   60/60 (100%)        46/50 (92%)   44/50 (88%)   47/60 (78%)    |
|                                       49/50 (98%)   49/50 (98%)   47/50 (94%)         33/50 (66%)   45/50 (90%)   42/50 (84%)    |
| Overall Incidence               Total 447/460 (97.17%)Mean 97.11%  SD 2.26%     Total 393/460 (85.43%) Mean 85.59%  SD 8.9%      |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Tumors                    21/50 (42%)   22/50 (44%)   22/50 (44%)         18/50 (36%)   19/50 (38%)   19/50 (38%)    |
|                                       27/50 (54%)   34/50 (68%)   37/60 (62%)         21/50 (42%)   22/50 (44%)   24/60 (40%)    |
|                                       33/50 (66%)   28/50 (56%)   29/50 (58%)         22/50 (44%)   20/50 (40%)   16/50 (32%)    |
| Overall Incidence               Total 253/460 (55%)   Mean 54.85%  SD 9.72%     Total 181/460 (39.35%) Mean 39.33%  SD 3.87%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant and Benign Tumors         50/50 (100%)  50/50 (100%)  50/50 (100%)        47/50 (94%)   45/50 (90%)   48/50 (96%)    |
|                                       49/50 (98%)   50/50 (100%)  60/60 (100%)        49/50 (98%)   48/50 (96%)   54/60 (90%)    |
|                                       50/50 (100%)  50/50 (100%)  50/50 (100%)        43/50 (86%)   47/50 (94%)   45/50 (90%)    |
| Overall Incidence               Total 459/460 (99.78%)Mean 99.78%  SD 0.67%     Total 426/460 (92.61%) Mean 92.67%  SD 3.87%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1.41%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.63%   SD 0.95%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Hemangiosarcoma or Hemangioma        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/460 (1.3%)    Mean 1.3%    SD 1.4%      Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Histiocytic Sarcoma                  1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     2/50 (4%)     |
|                                        1/50 (2%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/460 (1.09%)   Mean 1.07%   SD 1.43%     Total 2/460 (0.43%)    Mean 0.44%   SD 1.33%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Leukemia: Lymphocytic, Monocytic,   11/50 (22%)   15/50 (30%)   15/50 (30%)         10/50 (20%)    6/50 (12%)    9/50 (18%)    |
|      Mononuclear, or Undifferentiated 13/50 (26%)   13/50 (26%)   30/60 (50%)         11/50 (22%)    9/50 (18%)   21/60 (35%)    |
|                                       24/50 (48%)   16/50 (32%)   17/50 (34%)         13/50 (26%)   12/50 (24%)   11/50 (22%)    |
| Overall Incidence               Total 154/460 (33.48%)Mean 33.11%  SD 9.7%      Total 102/460 (22.17%) Mean 21.89%  SD 6.37%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 116
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Malignant Lymphoma: Histiocytic,     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Lymphocytic, Mixed, NOS, or       1/50 (2%)     2/50 (4%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Undifferentiated Cell Type        2/50 (4%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/460 (1.09%)   Mean 1.11%   SD 1.76%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Benign, Malignant,     4/50 (8%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      NOS                               0/50 (0%)     1/50 (2%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        5/50 (10%)    3/50 (6%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 20/460 (4.35%)  Mean 4.37%   SD 3.45%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Mesothelioma: Malignant              4/50 (8%)     2/50 (4%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        5/50 (10%)    3/50 (6%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 20/460 (4.35%)  Mean 4.37%   SD 3.45%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteoma                              0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 1.33%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        3/50 (6%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.85%   SD 2.01%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#All Organs:                                                                                                                      |
|   Osteosarcoma or Osteoma              0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        3/50 (6%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/460 (1.3%)    Mean 1.3%    SD 2.23%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     5/50 (10%)    1/49 (2%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     3/50 (6%)     2/60 (3%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     1/49 (2%)     |
| Overall Incidence               Total 2/458 (0.44%)   Mean 0.44%   SD 0.88%     Total 14/458 (3.06%)   Mean 3.05%   SD 3.16%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 117
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Adrenal Cortex:                                                                                                                  |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Ganglioneuroma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/454 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Benign              7/50 (14%)    8/50 (16%)    8/50 (16%)          1/50 (2%)     0/49 (0%)     2/48 (4%)     |
|                                        6/49 (12%)    3/50 (6%)     2/60 (3%)           2/50 (4%)     0/49 (0%)     2/60 (3%)     |
|                                        3/50 (6%)     8/50 (16%)    7/49 (14%)          2/49 (4%)     1/50 (2%)     1/49 (2%)     |
| Overall Incidence               Total 52/458 (11.35%) Mean 11.54%  SD 5.03%     Total 11/454 (2.42%)   Mean 2.4%    SD 1.63%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Complex             0/50 (0%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/49 (0%)     0/48 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/49 (0%)           0/49 (0%)     0/50 (0%)     0/49 (0%)     |
| Overall Incidence               Total 4/458 (0.87%)   Mean 0.89%   SD 1.76%     Total 0/454 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma Malignant           0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     1/48 (2%)     |
|                                        3/49 (6%)     4/50 (8%)     2/60 (3%)           0/50 (0%)     0/49 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/49 (0%)     1/50 (2%)     0/49 (0%)     |
| Overall Incidence               Total 10/458 (2.18%)  Mean 2.16%   SD 3.05%     Total 3/454 (0.66%)    Mean 0.68%   SD 1.01%     |
 __________________________________________________________________________________________________________________________________
|*Adrenal Medulla:                                                                                                                 |
|   Pheochromocytoma: Benign,            7/50 (14%)    8/50 (16%)   10/50 (20%)          2/50 (4%)     0/49 (0%)     3/48 (6%)     |
|      Complex, Malignant, NOS           9/49 (18%)    6/50 (12%)    4/60 (7%)           2/50 (4%)     0/49 (0%)     2/60 (3%)     |
|                                        3/50 (6%)    11/50 (22%)    7/49 (14%)          2/49 (4%)     2/50 (4%)     1/49 (2%)     |
| Overall Incidence               Total 65/458 (14.19%) Mean 14.37%  SD 5.52%     Total 14/454 (3.08%)   Mean 3.08%   SD 2.05%     |
 __________________________________________________________________________________________________________________________________
|#Blood Vessel:                                                                                                                    |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Chordoma                             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 118
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteoma                              0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 1.33%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.41%   SD 0.81%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Bone:                                                                                                                            |
|   Osteosarcoma or Osteoma              0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.85%   SD 1.43%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Astrocytoma Malignant                0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 3/459 (0.65%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Glioma Malignant                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Granular Cell Tumor Malignant        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Meningioma: Benign, Malignant, NOS   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/459 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 119
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Benign             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma Malignant          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Oligodendroglioma, Glioma, or        0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|      Astrocytoma                       0/50 (0%)     1/50 (2%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.89%   SD 1.45%     Total 3/459 (0.65%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Brain:                                                                                                                           |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Adenoma                              1/49 (2%)     0/50 (0%)     2/50 (4%)           5/50 (10%)    5/50 (10%)    8/50 (16%)    |
|                                        1/48 (2%)     1/50 (2%)     2/60 (3%)          11/49 (22%)    2/50 (4%)    12/59 (20%)    |
|                                        2/50 (4%)     2/50 (4%)     3/50 (6%)           7/50 (14%)    7/49 (14%)    8/50 (16%)    |
| Overall Incidence               Total 14/457 (3.06%)  Mean 3.05%   SD 1.73%     Total 65/457 (14.22%)  Mean 14.12%  SD 5.61%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma                            3/49 (6%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     3/50 (6%)     2/50 (4%)     |
|                                        3/48 (6%)     1/50 (2%)     2/60 (3%)           3/49 (6%)     2/50 (4%)     2/59 (3%)     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     3/49 (6%)     1/50 (2%)     |
| Overall Incidence               Total 12/457 (2.63%)  Mean 2.63%   SD 2.48%     Total 20/457 (4.38%)   Mean 4.4%    SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Carcinoma or Adenoma                 4/49 (8%)     0/50 (0%)     2/50 (4%)           7/50 (14%)    8/50 (16%)   10/50 (20%)    |
|                                        4/48 (8%)     2/50 (4%)     4/60 (7%)          14/49 (29%)    4/50 (8%)    14/59 (24%)    |
|                                        4/50 (8%)     3/50 (6%)     3/50 (6%)           8/50 (16%)   10/49 (20%)    9/50 (18%)    |
| Overall Incidence               Total 26/457 (5.69%)  Mean 5.68%   SD 2.69%     Total 84/457 (18.38%)  Mean 18.3%   SD 5.89%     |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Hemangiosarcoma                      0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 120
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Sarcoma                              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Schwannoma Malignant                 0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/457 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Clitoral/Preputial Gland:                                                                                                        |
|   Squamous Cell Papilloma              0/49 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/457 (0.22%)   Mean 0.22%   SD 0.67%     Total 1/457 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Ear:                                                                                                                             |
|   Neural Crest Tumor                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Amelanotic Melanoma, Benign          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Benign                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Eye:                                                                                                                             |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 121
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Harderian Gland:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Heart:                                                                                                                           |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 122
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Polyp Adenomatous                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.19%   SD 0.56%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Intestine Large: Colon/Rectum                                                                                                    |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Jejunum                                                                                                         |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 123
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Intestine Small: Site Unspecified                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Adenoma                              4/50 (8%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        3/50 (6%)     5/50 (10%)    2/60 (3%)           2/50 (4%)     0/50 (0%)     1/60 (2%)     |
|                                        3/50 (6%)     3/49 (6%)     5/48 (10%)          0/50 (0%)     2/50 (4%)     0/47 (0%)     |
| Overall Incidence               Total 28/457 (6.13%)  Mean 6.21%   SD 3.21%     Total 6/456 (1.32%)    Mean 1.3%    SD 1.72%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     2/50 (4%)     0/49 (0%)     |
|                                        2/50 (4%)     2/50 (4%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 6/457 (1.31%)   Mean 1.33%   SD 2%        Total 3/456 (0.66%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Islets, Pancreatic:                                                                                                              |
|   Carcinoma or Adenoma                 4/50 (8%)     0/50 (0%)     3/50 (6%)           1/50 (2%)     2/50 (4%)     0/49 (0%)     |
|                                        5/50 (10%)    7/50 (14%)    2/60 (3%)           3/50 (6%)     0/50 (0%)     1/60 (2%)     |
|                                        5/50 (10%)    3/49 (6%)     5/48 (10%)          0/50 (0%)     2/50 (4%)     0/47 (0%)     |
| Overall Incidence               Total 34/457 (7.44%)  Mean 7.54%   SD 4.2%      Total 9/456 (1.97%)    Mean 1.96%   SD 2.24%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma                            0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/452 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|   Carcinoma or Adenoma                 0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/452 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Pelvis and Transitional                                                                                                  |
| Epithelium                             0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     1/48 (2%)     |
|   Papilloma                            0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/452 (0%)      Mean 0%      SD 0%        Total 1/458 (0.22%)    Mean 0.23%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Adenoma                              0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/452 (0.22%)   Mean 0.23%   SD 0.68%     Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 124
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/452 (0%)      Mean 0%      SD 0%        Total 1/458 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Carcinoma or Adenoma                 0/50 (0%)     0/49 (0%)     0/48 (0%)           1/50 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/49 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/452 (0.22%)   Mean 0.23%   SD 0.68%     Total 1/458 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Fibroma                              0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/452 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Lipoma                               0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/452 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Liposarcoma                          0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/452 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Sarcoma                              0/50 (0%)     0/49 (0%)     1/48 (2%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/452 (0.22%)   Mean 0.23%   SD 0.69%     Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Kidney: Renal Tubule                                                                                                             |
|   Stromal Nephroma                     0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/452 (0%)      Mean 0%      SD 0%        Total 0/458 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Cholangiocarcinoma                   0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 125
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Adenoma               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     6/50 (12%)    1/60 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.81%   SD 1.28%     Total 11/460 (2.39%)   Mean 2.41%   SD 3.85%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma             0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.41%   SD 0.81%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Hepatoblastoma                    0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.41%   SD 0.81%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma or          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Hepatocellular Adenoma            0/50 (0%)     0/50 (0%)     3/60 (5%)           0/50 (0%)     6/50 (12%)    1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 6/460 (1.3%)    Mean 1.22%   SD 1.72%     Total 11/460 (2.39%)   Mean 2.41%   SD 3.85%     |
 __________________________________________________________________________________________________________________________________
|*Liver:                                                                                                                           |
|   Hepatocellular Carcinoma,            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Hepatocellular Adenoma, or        0/50 (0%)     0/50 (0%)     3/60 (5%)           0/50 (0%)     6/50 (12%)    1/60 (2%)     |
|      Hepatoblastoma                    1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     2/50 (4%)     |
| Overall Incidence               Total 6/460 (1.3%)    Mean 1.22%   SD 1.72%     Total 11/460 (2.39%)   Mean 2.41%   SD 3.85%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Adenoma         1/50 (2%)     2/50 (4%)     0/50 (0%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     1/60 (2%)           1/50 (2%)     0/50 (0%)     1/60 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
| Overall Incidence               Total 9/460 (1.96%)   Mean 1.96%   SD 1.42%     Total 8/460 (1.74%)    Mean 1.74%   SD 2.11%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma       0/50 (0%)     2/50 (4%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        3/50 (6%)     0/50 (0%)     1/60 (2%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 7/460 (1.52%)   Mean 1.52%   SD 2.18%     Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 126
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Alveolar/Bronchiolar Carcinoma or    1/50 (2%)     4/50 (8%)     0/50 (0%)           3/50 (6%)     0/50 (0%)     0/50 (0%)     |
|      Alveolar/Bronchiolar Adenoma      4/50 (8%)     1/50 (2%)     2/60 (3%)           2/50 (4%)     0/50 (0%)     1/60 (2%)     |
|                                        1/50 (2%)     1/50 (2%)     2/50 (4%)           0/50 (0%)     2/50 (4%)     2/50 (4%)     |
| Overall Incidence               Total 16/460 (3.48%)  Mean 3.48%   SD 2.78%     Total 10/460 (2.17%)   Mean 2.19%   SD 2.34%     |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Lung:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Lymph Node, Mesenteric:                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 127
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           3/50 (6%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 6/460 (1.3%)     Mean 1.33%   SD 2.24%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma                            2/50 (4%)     0/50 (0%)     0/50 (0%)           2/50 (4%)     4/50 (8%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           3/50 (6%)     4/50 (8%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           1/50 (2%)     2/50 (4%)     3/50 (6%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1.41%     Total 21/460 (4.57%)   Mean 4.67%   SD 2.65%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     0/50 (0%)           3/50 (6%)     4/50 (8%)     2/50 (4%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           6/50 (12%)    4/50 (8%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     3/50 (6%)     3/50 (6%)     |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.89%   SD 1.45%     Total 26/460 (5.65%)   Mean 5.78%   SD 3.53%     |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroadenoma                         3/50 (6%)     0/50 (0%)     3/50 (6%)          22/50 (44%)   26/50 (52%)   24/50 (48%)    |
|                                        2/50 (4%)     0/50 (0%)     0/60 (0%)          33/50 (66%)   12/50 (24%)   23/60 (38%)    |
|                                        0/50 (0%)     1/50 (2%)     4/50 (8%)          14/50 (28%)   28/50 (56%)   32/50 (64%)    |
| Overall Incidence               Total 13/460 (2.83%)  Mean 2.89%   SD 3.18%     Total 214/460 (46.52%) Mean 46.7%   SD 14.71%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma or Adenoma     3/50 (6%)     0/50 (0%)     3/50 (6%)          23/50 (46%)   26/50 (52%)   24/50 (48%)    |
|                                        2/50 (4%)     0/50 (0%)     0/60 (0%)          35/50 (70%)   12/50 (24%)   23/60 (38%)    |
|                                        0/50 (0%)     2/50 (4%)     4/50 (8%)          14/50 (28%)   28/50 (56%)   32/50 (64%)    |
| Overall Incidence               Total 14/460 (3.04%)  Mean 3.11%   SD 3.18%     Total 217/460 (47.17%) Mean 47.37%  SD 15.37%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Fibroma, Fibroadenoma, Carcinoma,    5/50 (10%)    0/50 (0%)     3/50 (6%)          24/50 (48%)   28/50 (56%)   25/50 (50%)    |
|      or Adenoma                        2/50 (4%)     0/50 (0%)     0/60 (0%)          37/50 (74%)   14/50 (28%)   23/60 (38%)    |
|                                        0/50 (0%)     2/50 (4%)     5/50 (10%)         14/50 (28%)   30/50 (60%)   32/50 (64%)    |
| Overall Incidence               Total 17/460 (3.7%)   Mean 3.78%   SD 4.18%     Total 227/460 (49.35%) Mean 49.59%  SD 15.87%    |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 128
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Mammary Gland:                                                                                                                   |
|   Myoepithelioma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Mesentery:                                                                                                                       |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 129
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/457 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Chondroma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/457 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/457 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Nose:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/457 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Papilloma Squamous or Papilloma      1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 4/460 (0.87%)    Mean 0.89%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Oral Cavity (Oral Mucosa, Tongue,                                                                                                |
| Pharynx, Tooth, Gingiva):                                                                                                        |
|   Squamous Cell Carcinoma,             1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous, or Papilloma  0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     3/50 (6%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           2/50 (4%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 6/460 (1.3%)     Mean 1.33%   SD 2.24%     |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 130
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Oral Mucosa:                                                                                                                     |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Cystadenoma                                                                          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Benign                                                          0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor Malignant                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa Cell Tumor: Benign,                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Malignant, NOS                                                                    1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Granulosa-Theca Tumor Malignant                                                      0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Luteoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 131
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Thecoma Malignant                                                                    0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Ovary:                                                                                                                           |
|   Tubulostromal Adenoma                                                                0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Adenoma                             10/50 (20%)    1/49 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     3/50 (6%)     1/60 (2%)           2/50 (4%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     3/49 (6%)     0/48 (0%)           0/50 (0%)     1/50 (2%)     0/47 (0%)     |
| Overall Incidence               Total 19/455 (4.18%)  Mean 4.2%    SD 6.38%     Total 4/456 (0.88%)    Mean 0.89%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma                            0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 1/455 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Carcinoma or Adenoma                10/50 (20%)    1/49 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     3/50 (6%)     1/60 (2%)           2/50 (4%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     3/49 (6%)     0/48 (0%)           0/50 (0%)     1/50 (2%)     0/47 (0%)     |
| Overall Incidence               Total 20/455 (4.4%)   Mean 4.43%   SD 6.25%     Total 4/456 (0.88%)    Mean 0.89%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Fibroma                              0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/455 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pancreas:                                                                                                                        |
|   Mixed Tumor Benign                   0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/49 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/48 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/455 (0%)      Mean 0%      SD 0%        Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Parathyroid Gland:                                                                                                               |
|   Adenoma                              0/50 (0%)     0/47 (0%)     1/48 (2%)           0/49 (0%)     0/49 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/58 (0%)           0/47 (0%)     0/45 (0%)     0/57 (0%)     |
|                                        0/48 (0%)     0/48 (0%)     0/50 (0%)           0/46 (0%)     0/48 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/447 (0.22%)   Mean 0.23%   SD 0.69%     Total 0/441 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 132
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Peripheral Nerve:                                                                                                                |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      12/50 (24%)    9/50 (18%)   16/49 (33%)         19/50 (38%)   23/50 (46%)   29/48 (60%)    |
|   Adenoma                             16/48 (33%)   29/50 (58%)   11/59 (19%)         23/49 (47%)   33/50 (66%)   19/59 (32%)    |
|                                       15/48 (31%)   22/49 (45%)   23/50 (46%)         15/50 (30%)   27/50 (54%)   26/50 (52%)    |
| Overall Incidence               Total 153/453 (33.77%)Mean 34.09%  SD 13.42%    Total 214/456 (46.93%) Mean 47.28%  SD 12.27%    |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     2/50 (4%)     0/48 (0%)     |
|   Carcinoma                            0/48 (0%)     5/50 (10%)    0/59 (0%)           1/49 (2%)     3/50 (6%)     0/59 (0%)     |
|                                        1/48 (2%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/453 (1.32%)   Mean 1.34%   SD 3.32%     Total 6/456 (1.32%)    Mean 1.34%   SD 2.24%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Distalis or                                                                                                |
| Unspecified Site                      12/50 (24%)    9/50 (18%)   16/49 (33%)         19/50 (38%)   25/50 (50%)   29/48 (60%)    |
|   Carcinoma or Adenoma                16/48 (33%)   34/50 (68%)   11/59 (19%)         24/49 (49%)   36/50 (72%)   19/59 (32%)    |
|                                       16/48 (33%)   22/49 (45%)   23/50 (46%)         15/50 (30%)   27/50 (54%)   26/50 (52%)    |
| Overall Incidence               Total 159/453 (35.1%) Mean 35.43%  SD 15.79%    Total 220/456 (48.25%) Mean 48.62%  SD 13.5%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Adenoma                              0/50 (0%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     2/50 (4%)     0/59 (0%)           1/49 (2%)     0/50 (0%)     1/59 (2%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 3/453 (0.66%)   Mean 0.67%   SD 1.41%     Total 4/456 (0.88%)    Mean 0.86%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     1/50 (2%)     0/59 (0%)           0/49 (0%)     0/50 (0%)     0/59 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/453 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/456 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Pituitary Gland: Pars Intermedia                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     1/50 (2%)     0/49 (0%)           1/50 (2%)     0/50 (0%)     0/48 (0%)     |
|                                        0/48 (0%)     3/50 (6%)     0/59 (0%)           1/49 (2%)     0/50 (0%)     1/59 (2%)     |
|                                        0/48 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 4/453 (0.88%)   Mean 0.89%   SD 2.03%     Total 4/456 (0.88%)    Mean 0.86%   SD 1.02%     |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Adenoma                              2/49 (4%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     2/60 (3%)                                                     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 7/459 (1.53%)   Mean 1.49%   SD 1.86%                                                      |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 133
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Prostate:                                                                                                                        |
|   Carcinoma or Adenoma                 2/49 (4%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     1/50 (2%)     2/60 (3%)                                                     |
|                                        2/50 (4%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 7/459 (1.53%)   Mean 1.49%   SD 1.86%                                                      |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/458 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     1/49 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/458 (0.22%)   Mean 0.23%   SD 0.68%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Salivary Glands:                                                                                                                 |
|   Schwannoma Malignant                 1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/49 (0%)     0/49 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/458 (0.44%)   Mean 0.44%   SD 0.88%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Hemangiosarcoma                      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 134
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 1/460 (0.22%)    Mean 0.19%   SD 0.56%     |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma                     0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Rhabdomyosarcoma or Rhabdomyoma      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skeletal Muscle:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Adenoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin: Sebaceous Gland                                                                                                            |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma                   0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/460 (1.09%)   Mean 1.04%   SD 1.3%      Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 135
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma or                0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Basosquamous Tumor Benign         0/50 (0%)     0/50 (0%)     2/60 (3%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 5/460 (1.09%)   Mean 1.04%   SD 1.3%      Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Adenoma, Basosquamous     1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Tumor Benign, or                  1/50 (2%)     0/50 (0%)     2/60 (3%)           2/50 (4%)     0/50 (0%)     0/60 (0%)     |
|      Trichoepithelioma                 1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 9/460 (1.96%)   Mean 1.93%   SD 0.85%     Total 4/460 (0.87%)    Mean 0.89%   SD 1.45%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 3/460 (0.65%)    Mean 0.67%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma or              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Basosquamous Tumor (malignant or  0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|      NOS)                              0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 3/460 (0.65%)    Mean 0.67%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal Cell Carcinoma, Basal Cell     1/50 (2%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     2/50 (4%)     1/50 (2%)     |
|      Adenoma, Basosquamous Tumor       1/50 (2%)     0/50 (0%)     2/60 (3%)           3/50 (6%)     0/50 (0%)     0/60 (0%)     |
|      (benign, malignant or NOS), or    1/50 (2%)     2/50 (4%)     2/50 (4%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 11/460 (2.39%)  Mean 2.37%   SD 1.25%     Total 7/460 (1.52%)    Mean 1.56%   SD 2.19%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Basal or Sq. Cell Carcinoma,         5/50 (10%)    2/50 (4%)     3/50 (6%)           1/50 (2%)     2/50 (4%)     2/50 (4%)     |
|      Carcinoma, Basosq. Tumor (M or    5/50 (10%)    4/50 (8%)     7/60 (12%)          3/50 (6%)     1/50 (2%)     0/60 (0%)     |
|      B), Basal Cell Adenoma, Adenoma,  4/50 (8%)     4/50 (8%)     7/50 (14%)          0/50 (0%)     1/50 (2%)     1/50 (2%)     |
|      Papilloma, Sq Papilloma,                                                                                                    |
|      Keratoacanthoma,                                                                                                            |
|      Trichoepithelioma                                                                                                           |
| Overall Incidence               Total 41/460 (8.91%)  Mean 8.85%   SD 2.98%     Total 11/460 (2.39%)   Mean 2.44%   SD 1.94%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangioma                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        2/50 (4%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1.41%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiopericytoma                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 136
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Hemangiosarcoma                      0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.19%   SD 0.56%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Keratoacanthoma                      3/50 (6%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        4/50 (8%)     3/50 (6%)     5/60 (8%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        2/50 (4%)     3/50 (6%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 25/460 (5.43%)  Mean 5.37%   SD 2.29%     Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Lipoma                               1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 3/460 (0.65%)    Mean 0.67%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Melanoma Malignant                   0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neural Crest Tumor                   1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Osteosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 137
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Carcinoma, Basal       0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Cell Carcinoma, Basosquamous      0/50 (0%)     0/50 (0%)     0/60 (0%)           1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|      Tumor (malignant or NOS), or      0/50 (0%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|      Carcinoma                                                                                                                   |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1%        Total 3/460 (0.65%)    Mean 0.67%   SD 1%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 5/460 (1.09%)   Mean 1.11%   SD 1.45%     Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma or           1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma                         0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     2/50 (4%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 5/460 (1.09%)   Mean 1.11%   SD 1.45%     Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)     1/50 (2%)     2/50 (4%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma, Squamous Cell          4/50 (8%)     4/50 (8%)     5/60 (8%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|      Carcinoma or Keratoacanthoma      3/50 (6%)     3/50 (6%)     6/50 (12%)          0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 32/460 (6.96%)  Mean 6.93%   SD 2.87%     Total 4/460 (0.87%)    Mean 0.89%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Squamous Cell Papilloma,             4/50 (8%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     1/50 (2%)     |
|      Papilloma, or Keratoacanthoma     4/50 (8%)     4/50 (8%)     5/60 (8%)           0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                        3/50 (6%)     3/50 (6%)     5/50 (10%)          0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 30/460 (6.52%)  Mean 6.48%   SD 2.81%     Total 4/460 (0.87%)    Mean 0.89%   SD 1.05%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Trichoepithelioma                    1/50 (2%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           2/50 (4%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.89%   SD 1.05%     Total 3/460 (0.65%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma                              4/50 (8%)     2/50 (4%)     8/50 (16%)          2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|                                        9/50 (18%)    5/50 (10%)    5/60 (8%)           4/50 (8%)     0/50 (0%)     3/60 (5%)     |
|                                        1/50 (2%)     6/50 (12%)    5/50 (10%)          0/50 (0%)     1/50 (2%)     1/50 (2%)     |
| Overall Incidence               Total 45/460 (9.78%)  Mean 9.81%   SD 5.13%     Total 13/460 (2.83%)   Mean 2.78%   SD 2.54%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibroma, Fibrosarcoma, Sarcoma,      7/50 (14%)    2/50 (4%)     8/50 (16%)          2/50 (4%)     1/50 (2%)     1/50 (2%)     |
|      Myxoma, Myxosarcoma, or Fibrous  10/50 (20%)    5/50 (10%)    5/60 (8%)           4/50 (8%)     0/50 (0%)     3/60 (5%)     |
|      Histiocytoma                      2/50 (4%)     7/50 (14%)    6/50 (12%)          2/50 (4%)     3/50 (6%)     1/50 (2%)     |
| Overall Incidence               Total 52/460 (11.3%)  Mean 11.37%  SD 5.36%     Total 17/460 (3.7%)    Mean 3.67%   SD 2.45%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 138
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma                         3/50 (6%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 4/460 (0.87%)   Mean 0.89%   SD 2.03%     Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrosarcoma, Sarcoma,               3/50 (6%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Myxosarcoma, or Fibrous           1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|      Histiocytoma                      1/50 (2%)     1/50 (2%)     1/50 (2%)           2/50 (4%)     2/50 (4%)     0/50 (0%)     |
| Overall Incidence               Total 7/460 (1.52%)   Mean 1.56%   SD 1.94%     Total 4/460 (0.87%)    Mean 0.89%   SD 1.76%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Fibrous Histiocytoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Myxosarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibroma or Schwannoma benign    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma or Schwannoma      0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      (malignant or NOS)                0/50 (0%)     2/50 (4%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1.41%     Total 3/460 (0.65%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Neurofibrosarcoma, Neurofibroma,     0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      or Schwannoma (benign, malignant  0/50 (0%)     2/50 (4%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|      or NOS)                           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1.41%     Total 3/460 (0.65%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 139
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     1/50 (2%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Benign                    0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Skin:                                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     2/50 (4%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 3/460 (0.65%)   Mean 0.67%   SD 1.41%     Total 3/460 (0.65%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangioma                           0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/48 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 0/455 (0%)      Mean 0%      SD 0%        Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Spleen:                                                                                                                          |
|   Hemangiosarcoma                      0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     1/48 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/47 (0%)     |
| Overall Incidence               Total 1/455 (0.22%)   Mean 0.23%   SD 0.69%     Total 0/457 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Lipoma                               1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 140
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Forestomach:                                                                                                            |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Carcinoma or Adenoma                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Stomach, Glandular:                                                                                                              |
|   Lipoma                               0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Adenoma                             41/50 (82%)   48/50 (96%)   46/50 (92%)                                                    |
|                                       45/50 (90%)   36/50 (72%)   55/60 (92%)                                                    |
|                                       49/50 (98%)   45/50 (90%)   41/50 (82%)                                                    |
| Overall Incidence               Total 406/460 (88.26%)Mean 88.19%  SD 8.13%                                                      |
 __________________________________________________________________________________________________________________________________
|*Testes:                                                                                                                          |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)                                                     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)                                                     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%                                                         |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 141
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Sarcoma                              0/50 (0%)     0/48 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/56 (0%)           0/49 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     1/49 (2%)           0/48 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/445 (0.22%)   Mean 0.23%   SD 0.68%     Total 0/444 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Benign                       0/50 (0%)     0/48 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/56 (0%)           0/49 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     1/49 (2%)           0/48 (0%)     0/48 (0%)     0/49 (0%)     |
| Overall Incidence               Total 1/445 (0.22%)   Mean 0.23%   SD 0.68%     Total 0/444 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma Malignant                    0/50 (0%)     0/48 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/56 (0%)           0/49 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     0/49 (0%)           0/48 (0%)     1/48 (2%)     0/49 (0%)     |
| Overall Incidence               Total 0/445 (0%)      Mean 0%      SD 0%        Total 1/444 (0.23%)    Mean 0.23%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Thymus:                                                                                                                          |
|   Thymoma: Benign, Malignant, NOS      0/50 (0%)     0/48 (0%)     0/48 (0%)           0/48 (0%)     0/48 (0%)     0/47 (0%)     |
|                                        0/48 (0%)     0/49 (0%)     0/56 (0%)           0/49 (0%)     0/50 (0%)     0/57 (0%)     |
|                                        0/49 (0%)     0/48 (0%)     1/49 (2%)           0/48 (0%)     1/48 (2%)     0/49 (0%)     |
| Overall Incidence               Total 1/445 (0.22%)   Mean 0.23%   SD 0.68%     Total 1/444 (0.23%)    Mean 0.23%   SD 0.69%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Adenoma                              4/50 (8%)     9/48 (19%)   11/47 (23%)         12/50 (24%)    9/49 (18%)   10/47 (21%)    |
|                                        9/47 (19%)    5/50 (10%)   10/59 (17%)         12/47 (26%)    3/50 (6%)     9/60 (15%)    |
|                                       11/50 (22%)    8/46 (17%)    6/50 (12%)          6/50 (12%)    2/49 (4%)     6/50 (12%)    |
| Overall Incidence               Total 73/447 (16.33%) Mean 16.4%   SD 5.31%     Total 69/452 (15.27%)  Mean 15.36%  SD 7.58%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma                            1/50 (2%)     1/48 (2%)     0/47 (0%)           1/50 (2%)     0/49 (0%)     1/47 (2%)     |
|                                        2/47 (4%)     5/50 (10%)    0/59 (0%)           1/47 (2%)     2/50 (4%)     1/60 (2%)     |
|                                        0/50 (0%)     1/46 (2%)     1/50 (2%)           0/50 (0%)     1/49 (2%)     0/50 (0%)     |
| Overall Incidence               Total 11/447 (2.46%)  Mean 2.5%    SD 3.14%     Total 7/452 (1.55%)    Mean 1.55%   SD 1.34%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: C-Cell                                                                                                            |
|   Carcinoma or Adenoma                 5/50 (10%)   10/48 (21%)   11/47 (23%)         13/50 (26%)    9/49 (18%)   11/47 (23%)    |
|                                       11/47 (23%)   10/50 (20%)   10/59 (17%)         13/47 (28%)    5/50 (10%)   10/60 (17%)    |
|                                       11/50 (22%)    9/46 (20%)    7/50 (14%)          6/50 (12%)    3/49 (6%)     6/50 (12%)    |
| Overall Incidence               Total 84/447 (18.79%) Mean 18.91%  SD 4.51%     Total 76/452 (16.81%)  Mean 16.91%  SD 7.54%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Adenoma                              0/50 (0%)     1/48 (2%)     0/47 (0%)           0/50 (0%)     0/49 (0%)     2/47 (4%)     |
|                                        1/47 (2%)     1/50 (2%)     0/59 (0%)           0/47 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     1/50 (2%)           0/50 (0%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 4/447 (0.89%)   Mean 0.91%   SD 1.08%     Total 2/452 (0.44%)    Mean 0.47%   SD 1.42%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 142
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma                            1/50 (2%)     0/48 (0%)     0/47 (0%)           1/50 (2%)     1/49 (2%)     0/47 (0%)     |
|                                        0/47 (0%)     0/50 (0%)     1/59 (2%)           1/47 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     0/50 (0%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/447 (0.45%)   Mean 0.41%   SD 0.82%     Total 5/452 (1.11%)    Mean 1.13%   SD 1.07%     |
 __________________________________________________________________________________________________________________________________
|*Thyroid Gland: Follicular Cell                                                                                                   |
|   Carcinoma or Adenoma                 1/50 (2%)     1/48 (2%)     0/47 (0%)           1/50 (2%)     1/49 (2%)     2/47 (4%)     |
|                                        1/47 (2%)     1/50 (2%)     1/59 (2%)           1/47 (2%)     1/50 (2%)     0/60 (0%)     |
|                                        0/50 (0%)     0/46 (0%)     1/50 (2%)           1/50 (2%)     0/49 (0%)     0/50 (0%)     |
| Overall Incidence               Total 6/447 (1.34%)   Mean 1.32%   SD 1%        Total 7/452 (1.55%)    Mean 1.6%    SD 1.4%      |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Fibrosarcoma                         0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Leiomyoma                            0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Paraganglioma                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        1/50 (2%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Sarcoma                              0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Tissue NOS:                                                                                                                      |
|   Schwannoma Malignant                 0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Liposarcoma                          0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 143
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Carcinoma or           0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|      Papilloma Squamous                0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 3/460 (0.65%)    Mean 0.67%   SD 1.41%     |
 __________________________________________________________________________________________________________________________________
|#Tongue:                                                                                                                          |
|   Squamous Cell Papilloma              0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     2/50 (4%)     0/60 (0%)     |
|                                        0/50 (0%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/460 (0.22%)   Mean 0.22%   SD 0.67%     Total 2/460 (0.43%)    Mean 0.44%   SD 1.33%     |
 __________________________________________________________________________________________________________________________________
|#Tooth:                                                                                                                           |
|   Odontogenic Tumor                    0/50 (0%)     0/50 (0%)     0/50 (0%)           1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/460 (0%)      Mean 0%      SD 0%        Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 1/456 (0.22%)   Mean 0.22%   SD 0.67%     Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Carcinoma or Papilloma               0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     1/50 (2%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 2/456 (0.44%)   Mean 0.41%   SD 0.81%     Total 2/459 (0.44%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Leiomyosarcoma                       0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Papilloma                            0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     1/50 (2%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     1/60 (2%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence               Total 1/456 (0.22%)   Mean 0.19%   SD 0.56%     Total 2/459 (0.44%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 144
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|*Urinary Bladder:                                                                                                                 |
|   Sarcoma                              0/50 (0%)     0/50 (0%)     0/49 (0%)           0/50 (0%)     0/50 (0%)     0/49 (0%)     |
|                                        0/48 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                        0/50 (0%)     0/49 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 0/456 (0%)      Mean 0%      SD 0%        Total 0/459 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Adenoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Carcinoma                                                                            1/50 (2%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Hemangioma                                                                           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     1/50 (2%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Polyp Stromal                                                                       14/50 (28%)    8/50 (16%)   16/50 (32%)    |
|                                                                                        9/50 (18%)   10/50 (20%)   11/60 (18%)    |
|                                                                                        6/50 (12%)   11/50 (22%)    4/50 (8%)     |
| Overall Incidence                                                               Total 89/460 (19.35%)  Mean 19.37%  SD 7.41%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 145
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal                                                                      0/50 (0%)     0/50 (0%)     1/50 (2%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 2/460 (0.43%)    Mean 0.44%   SD 0.88%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Sarcoma Stromal or Polyp Stromal                                                    14/50 (28%)    8/50 (16%)   17/50 (34%)    |
|                                                                                       10/50 (20%)   10/50 (20%)   11/60 (18%)    |
|                                                                                        6/50 (12%)   11/50 (22%)    4/50 (8%)     |
| Overall Incidence                                                               Total 91/460 (19.78%)  Mean 19.81%  SD 7.83%     |
 __________________________________________________________________________________________________________________________________
|#Uterus:                                                                                                                          |
|   Schwannoma Malignant                                                                 0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        1/50 (2%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/460 (0.22%)    Mean 0.22%   SD 0.67%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyoma                                                                            0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 1/460 (0.22%)    Mean 0.19%   SD 0.56%     |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Leiomyosarcoma                                                                       0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Vagina:                                                                                                                          |
|   Sarcoma                                                                              0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/60 (0%)     |
|                                                                                        0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence                                                               Total 0/460 (0%)       Mean 0%      SD 0%        |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Adenoma                              1/50 (2%)     0/50 (0%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        0/50 (0%)     0/50 (0%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
| Overall Incidence               Total 2/460 (0.43%)   Mean 0.44%   SD 0.88%     Total 1/460 (0.22%)    Mean 0.19%   SD 0.56%     |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma                            1/50 (2%)     0/50 (0%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     1/60 (2%)     |
|                                        2/50 (4%)     1/50 (2%)     0/50 (0%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 7/460 (1.52%)   Mean 1.56%   SD 2.19%     Total 2/460 (0.43%)    Mean 0.41%   SD 0.81%     |
 __________________________________________________________________________________________________________________________________

 *: Denominator is number of animals with tissues examined microscopically
 #: Denominator is number of animals necropsied
                                                 Toxicology Data Management System                                     Page: 146
 Version: 01/28/05                       Tumor Incidence for Selected Control Animal Groups

 Contract/Lab: SOUTHERN RESEARCH                         Route: ALL ROUTES                                 Date of
 Species: RATS                                           Vehicle: ALL VEHICLES                             Input File: 28-JAN-2005
 Strain: FISCHER344
 Length of Study: CHRONIC                   
                                             Incidence Data for Vehicle Control Groups
 __________________________________________________________________________________________________________________________________
|                                                   Male                                              Female                       |
 __________________________________________________________________________________________________________________________________
|#Zymbal's Gland:                                                                                                                  |
|   Carcinoma or Adenoma                 2/50 (4%)     0/50 (0%)     3/50 (6%)           0/50 (0%)     0/50 (0%)     0/50 (0%)     |
|                                        0/50 (0%)     0/50 (0%)     0/60 (0%)           0/50 (0%)     0/50 (0%)     2/60 (3%)     |
|                                        2/50 (4%)     1/50 (2%)     1/50 (2%)           0/50 (0%)     0/50 (0%)     1/50 (2%)     |
| Overall Incidence               Total 9/460 (1.96%)   Mean 2%      SD 2.24%     Total 3/460 (0.65%)    Mean 0.59%   SD 1.22%     |
 __________________________________________________________________________________________________________________________________
