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Nomination Summary for Carrageenan (N20130)

Nominated Substances: Carrageenan

Nomination Date: 07/30/2001

Nominator: Private Individual

Rationale: Carrageenan, a seaweed extract, is a widely used food additive that has been associated with the induction and promotion of intestinal neoplasms and ulcerations in animal experiments. Degraded carrageenan has been listed as a Class 2B substance by the IARC, included in the National Research Council listing of carcinogens, and designated by the Carcinogenic Potency Database with a reported TD50 of 2310 mg/kb body weight/day. It would be useful to consider production of free radicals and upregulation of known oncogenes following exposure to carrageenan.

NTP Principles: not specified

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