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Nomination Summary for Phenanthraquinone [9,10-Phenanthrenequinone] (N20520)

Nominated Substances: 1,2-Naphthoquinone, 1,4-Naphthoquinone, 9,10-Phenanthrenequinone

Nomination Date: 07/29/2005

Nominator: Private Individual

Rationale: This compound has been shown to have high potency for generating reactive oxygen species and recent reports also indicate other toxicologic pathways. This compound is found in the ambient environment and appears to be formed via atmospheric chemistry. It would be useful to test the two naphthoquinones as well, 1,2-Naphthoquinone and 1,4-Naphthoquinone. Given the electrophilic activity and the potential for ROS the quinones are worth further evaluation.

NTP Principles: not specified

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