Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Nomination Summary for Dong quai (Angelica sinensis root [308068-61-3] and extract [299184-76-2]) (N20812)

Nominated Substances: 3-Butylidenephthalide [551-08-6], Dong quai Angelica sinensis root, Dong quai (Angelica sinensis root extract), Ferulic Acid [1135-24-6], Ligustilide [4431-01-0]

Nomination Date: 08/20/2008

Nominator: Private Individual

Rationale: Widespread use as a dietary supplement; suspicion of toxicity based on estrogenic activity and chemical structure; lack of adequate toxicity data

NTP Principles: not specified

More Detailed Information