Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Nomination Summary for Energy Drink Components Mixture (N21302)

Nominated Substances: Acetyl-l-carnitine hydrochloride, Caffeine, Ginkgo biloba extract, Ginseng, Guarana, Inositol, Milk thistle extract, L-Taurine

Nomination Date: 11/05/2012

Nominator: Private Individual

Rationale: Although some of these components have been studied individually, there is not sufficient or adequate toxicological information available to fully assess the short-term and long-term safety of these enhanced drinks which contain mixtures of multiple compounds. The nomination of a mixture of energy drink components is further based on the popularity of energy drinks (especially among young adults), potential high levels of exposure, and possibility of chronic exposure. A mixture of caffeine, taurine, and guarana in a formulation at ratios commonly used in commercially-available energy drinks should minimally be considered. Consideration should also be given to inclusion of ginseng, inositol, L-carnitine, and/or the B vitamins.

NTP Principles: not specified

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 5080-50-2

Agent Name: Acetyl-l-carnitine hydrochloride

CASRN: 58-08-2

Agent Name: Caffeine

CASRN: 90045-36-6

Agent Name: Ginkgo biloba extract

CASRN: 50647-08-0

Agent Name: Ginseng

CASRN: 84604-20-6

Agent Name: Milk thistle extract

CASRN: 107-35-7

Agent Name: L-Taurine