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Nomination Summary for Caffeine (N96009)

Nominated Substances: Caffeine

Nomination Date: 03/22/1996

Nominator: Private Individual

Rationale: One of twenty-two substances nominated as naturally occurring chemicals in the diet. Since naturally occurring chemicals in the diet have not been a focus of cancer research, it seems reasonable to investigate some of them further as possible hazards because they often occur at high concentrations in foods. In addition, since regulatory agencies are considering a change in the standard protocol from ad libitum feeding to dietary restriction, it is important to know what impact that change will have on carcinogenicity sensitivity.

NTP Principles: not specified

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 58-08-2

Agent Name: Caffeine