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Nomination Summary for Carbonyl sulfide (N96034)

Nominated Substances: Carbonyl sulfide

Nomination Date: 05/17/1996

Nominator: EPA

Rationale: Carbonyl sulfide (CS) is a high production chemical that is listed as a hazardous air pollutant under the Clean Air Act Amendments of 1990. Even though it is included in a proposed TSCA Section 4 test rule on hazardous air pollutants, the EPA Office of Air Quality Planning and Standards has indicated a more immediate need for health data than might be accommodated under the TSCA rule. An EPA literature search was unable to find any subchronic or chronic toxicity, oncogenicity, or developmental toxicity data. No histopathology has been conducted on the upper or lower respiratory tract following acute, subchronic or chronic exposures. Since CS is chemically reactive, it is expected to react with tissues of the respiratory tract and may have carcinogenic potential. Also, CS is the oxidation product of carbon disulfide which has been shown to be positive in the strain A mouse lung tumor bioassay.

NTP Principles: 1, 2, 6

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 463-58-1

Agent Name: Carbonyl sulfide