Nomination Summary for Dimethylethanolamine (N97015)
Nominated Substances: Dimethylethanolamine (DMAE)
Nomination Date: 06/00/1997
Rationale: Potential for widespread human exposure to DMAE through its use in industrial and consumer products; inadequate toxicological database; some ethanolamines can interfere with choline uptake and utilization and may also generate nitrosamines QT interval prolongation and torsade de pointes is a high priority cause for concern in drug development and regulatory safety evaluation; a clear definition of the strengths, limitations, and future performance characteristics of the canine telemetry model for pre-clinical safety assessment is needed
NTP Principles: not specified
Agents and Status
The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.
Agent Name: Dimethylethanolamine (DMAE)