ICCVAM Biennial Report 2020-2021

ICCVAM. 2020. Biennial Progress Report 2018-2019 [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences [cited 17 February 2022]. Available: https://ntp.niehs.nih.gov/iccvamreport/2019/index.html.

ICCVAM. 2021. Measuring U.S. Federal Agency Progress Toward Implementation of Alternative Methods in Toxicity Testing [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences [cited 17 February 2022]. Available: https://ntp.niehs.nih.gov/iccvam/docs/about_docs/iccvam-measuringprogress-feb2021-fd-508.pdf.

NIEHS. 2020. Application of Non-animal Test Methods and Defined Approaches to Skin Sensitization Assessment of Isothiazolinone Compounds [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences [cited 17 February 2022]. Available: https://ntp.niehs.nih.gov/iccvam/methods/immunotox/it/niceatm-it-report-june2020-final-wappx-508.pdf.

NIEHS. 2021. Prospective and Retrospective Evaluation of the Eye Irritation Potential of Agrochemical Formulation [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences [cited 17 February 2022]. Available: https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/formulationreport_2021_fd-508.pdf.

All Federal Register notices issued by NICEATM can be found on the NTP website at /go/frn.

NIEHS. 2020. ICCVAM notice of public webcast; request for public input. Federal Register. 85(74): 21256-21257.

NIEHS. 2020. ICCVAM Biennial Progress Report: 2018-2019; availability of report. Federal Register. 85(137): 43249-43240.

NIEHS. 2021. ICCVAM Communities of Practice Webinar on Non-animal Approaches for Mixtures Assessment. Federal Register. 86(6): 1981-1982.

NIEHS. 2021. ICCVAM notice of public webcast; request for public input. Federal Register. 86(67): 18547-18548.

NIEHS. 2021. Request for data and information on new approach methodologies for efficacy testing of ectoparasiticide products to meet regulatory data requirements. Federal Register. 86(242): 72251.

NIEHS. 2021. ICCVAM Communities of Practice Webinar on New Approach Methodologies to Assess (Developmental) Neurotoxicity. Federal Register. 86(243): 72609-72610.

A full list of NICEATM and ICCVAM publications is available on the NTP website.

Abedini JA, Cook B, Bell S, Chang X, Choksi N, Daniel AB, Hines D, Karmaus AL, Mansouri K, McAfee E, Phillips J, Rooney J, Sprankle CS, Allen D, Casey W, Kleinstreuer N. 2021. Application of new approach methodologies: ICE tools to support chemical evaluations. Comput Toxicol 20:100184. https://doi.org/10.1016/j.comtox.2021.100184.

Allen D, Rooney J, Kleinstreuer N, Lowit A, Perron M. 2021. Retrospective analysis of dermal absorption triple pack data. ALTEX 38(3):463-476. https://doi.org/10.14573/altex.2101121.

Alves VM, Auerbach SS, Kleinstreuer NC, Rooney JP, Muratov EN, Rusyn I, Tropsha A, Schmitt C. 2021. Curated data in — trustworthy in silico models out: the impact of data quality on the reliability of artificial intelligence models as alternatives to animal testing. ATLA 49(3):73-82. https://doi.org/10.1177/02611929211029635.

Bassan A, Alves V, Amberg A, Anger LT, Auerbach S, Beilke L, Bender A, Cronin MTD, Cross KP, Hsieh JH, Greene N, Kemper R, Kim MT, Mumtaz M, Noeske T, Pavan M, Pletz J, Russo DP, Sabnis Y, Schaefer M, Szabo DT, Valentin JP, Wichard J, Williams D, Wooley D, Zwickl C, Myatt GJ. 2021. In silico approaches in organ toxicity hazard assessment: Current status and future needs in predicting liver toxicity. Comput Toxicol 20:100187. https://doi.org/10.1016/j.comtox.2021.100187.

Bassan A, Alves V, Amberg A, Anger LT, Beilke L, Bender A, Bernal A, Cronin MTD, Hsieh JH, Johnson C, Kemper R, Mumtaz M, Nielson L, Pavan M, Pointon A, Pletz J, Ruiz P, Russo DP, Sabnis Y, Sandhu R, Schaefer M, Stavitskaya L, Szabo DT, Valentin JP, Wooley D, Zwickl C, Myatt GJ. 2021. In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities. Comput Toxicol 20:100188. https://doi.org/10.1016/j.comtox.2021.100188.

Bell S, Abedini J, Ceger P, Chang X, Cook B, Karmaus AL, Lea I, Mansouri K, Phillips J, McAfee E, Rai R, Rooney J, Sprankle C, Tandon A, Allen D, Casey W, Kleinstreuer N. 2020. An integrated chemical environment with tools for chemical safety testing. Toxicol In Vitro 67:104916. https://doi.org/10.1016/j.tiv.2020.104916.

Borba J, Braga RC, Alves VM, Muratov EN, Kleinstreuer NC, Tropsha A, Andrade CH. 2021. Pred-Skin: A web portal for accurate prediction of human skin sensitizers. Chem Res Toxicol 34(2):258-267. https://doi.org/10.1021/acs.chemrestox.0c00186.

Borrel A, Auerbach S, Houck KA, Kleinstreuer NC. 2020. Tox21BodyMap: a webtool to map chemical effects on the human body. Nucleic Acids Res 48(W1):W472-W476. https://doi.org/10.1093/nar/gkaa433. Intramural Paper of the Month, NIEHS Environmental Factor August 2020.

Borrel A, Huang R, Sakamuru S, Xia M, Simeonov A, Mansouri K, Houck KA, Judson RS, Kleinstreuer NC. 2020. High-throughput screening to predict chemical-assay interference. Sci Rep 10:3986. https://doi.org/10.1038/s41598-020-60747-3.

Borrel A, Mansouri K, Nolte S, Saddler T, Conway M, Schmitt C, Kleinstreuer NC. 2020. InterPred: a webtool to predict chemical autofluorescence and luminescence interference. Nucleic Acids Res 48(W1):W586–W590. https://doi.org/10.1093/nar/gkaa378.

Brown J, Clippinger AJ, Briglia CF, Casey W, Coleman K, Fritsch A, Hartung T, Maouyo D, Muller T, Reich J, Robert L, Roeder R, Sanchez G, Sawyer AY, Solati S, Tirumalai R, Zwisler W, Allen D. 2021. Using the monocyte activation test as a stand-alone release test for medical devices. ALTEX 38(1):151-156. https://doi.org/10.14573/altex.2012021.

Choksi N, Lebrun S, Nguyen M, Daniel A, DeGeorge G, Willoughby J, Layton A, Lowther D, Merrill J, Matheson J, Barroso J, Yozzo K, Casey W, Allen D. 2020. Validation of the OptiSafe™ eye irritation test . Cutan Ocul Toxicol 39(3):180-192. https://doi.org/10.1080/15569527.2020.1787431. Paper of the Year (2020), Society of Toxicology Ocular Toxicity Specialty Section.

Clippinger AJ, Raabe HA, Allen DG, Choksi N, van der Zalm A, Kleinstreuer N, Barroso J, Lowit AB. 2021. Human-relevant approaches to assess eye corrosion/irritation potential of agrochemical formulations. Cutan Ocul Toxicol 40(2):145-167. https://doi.org/10.1080/15569527.2021.1910291.

Comess S, Akbay A, Vasiliou M, Hines RN, Joppa L, Vasiliou V, Kleinstreuer N. 2020. Bringing big data to bear in environmental health: challenges and recommendations. Front Artif Intell 3:31. https://doi.org/10.3389/frai.2020.00031.

Eskes C, Casati S, Kleinstreuer N, Ezendam J. 2021. Usefulness and applicability of integrated strategy approaches in toxicology. Appl In Vitro Toxicol 7(3):89-90. https://doi.org/10.1089/aivt.2021.0021.

Groff K, Allen D, Casey W, Clippinger A. 2020. Increasing the use of animal-free recombinant antibodies. ALTEX 37(2):309-311. https://doi.org/10.14573/altex.2001071.

Hagstrom A, Anastas P, Boissevain A, Borrel A, Deziel N, Fenton S, Fields C, Fortner J, Franceschi-Hofmann N, Frigon R, Jin L, Kim JH, Kleinstreuer N, Koelmel J, Lei Y, Liew Z, Ma X, Mathieu L, Nason S, Organtini K, Oulhote Y, Pociu S, Godri Pollitt K, Saiers J, Thompson D, Toal B, Weiner E, Whirledge S, Zhang Y, Vasiliou V. 2021. Yale School of Public Health Symposium: An overview of the challenges and opportunities associated with per- and polyfluoroalkyl substances (PFAS). Sci Total Environ 778:146192. https://doi.org/10.1016/j.scitotenv.2021.146192.

Hamm J, Allen D, Ceger P, Flint T, Lowit A, O'Dell L, Tao J, Kleinstreuer N. 2021. Performance of the GHS Mixtures Equation for predicting acute oral toxicity. Reg Toxicol Pharmacol. https://doi.org/10.1016/j.yrtph.2021.105007.

Jain S, Siramshetty VB, Alves VN, Muratov EN, Kleinstreuer NC, Tropsha A, Nicklaus MC, Simeonov N, Zakharov AV. 2021. Large-scale modeling of multispecies acute toxicity end points using consensus of multitask deep learning methods. J Chem Inf Modeling 61(2):653-663. https://doi.org/10.1021/acs.jcim.0c01164.

Judson R, Houck K, Paul Friedman K, Brown J, Browne P, Johnston PA, Close DA, Mansouri K, Kleinstreuer N. 2020. Selecting a minimal set of androgen receptor assays for screening chemicals. Reg Toxicol Pharmacol 117:104764. https://doi.org/10.1016/j.yrtph.2020.104764.

Kleinstreuer N, Holmes A. 2021. Harnessing the power of microphysiological systems for COVID-19 research. Drug Discov Today 26(11):2496-2501. https://doi.org/10.1016/j.drudis.2021.06.020.

Kleinstreuer NC, Tong W, Tetko IV. 2020. Computational toxicology [Editorial]. Chem Res Toxicol 33(3):687-688. https://doi.org/10.1021/acs.chemrestox.0c00070.

Knudsen TB, Fitzpatrick SC, De Abrew KN, Birnbaum LS, Chappelle A, Daston GP, Dolinoy DC, Elder A, Euling S, Faustman EM, Fedinick KP, Fransoza JA, Haggard DE, Haws L, Kleinstreuer N, Louis GMB, Mendrick DL, Rudel R, Saili KS, Schug TT, Tanguay RL, Turley AE, Wetmore BA, White KW, Zurlinden TJ. 2021. FutureTox IV workshop summary: Predictive Toxicology for Healthy Children. Toxicol Sci 180(2):198-211. https://doi.org/10.1093/toxsci/kfab013.

Krishna S, Berridge B, Kleinstreuer NC. 2021. High-throughput screening to identify chemical cardiotoxic potential. Chem Res Toxicol 34(2):566-583. https://doi.org/10.1021/acs.chemrestox.0c00382.

Li X, Kleinstreuer NC, Fourches D. 2020. Hierarchical quantitative and structure-activity relationship modeling approach for integrating binary, multiclass, and regression models of acute oral systemic toxicity. Chem Res Toxicol 33(2):353-366. https://doi.org/10.1021/acs.chemrestox.9b00259.

Mansouri K, Karmaus AL, Fitzpatrick J, Patlewicz G, Pradeep P, Alberga D, Alepee N, Allen THE, Allen DG, Alves VM, Andrade CH, Auernhammer TR, Ballabio D, Bell S, Benfenati E, Bhattacharya S, Bastos JV, Boyd S, Brown JB, Capuzzi SJ, Chushak Y, Ciallella H, Clark AM, Consonni V, Daga PR, Ekins S, Farag S, Fedorov M, Fourches D, Gadaleta D, Gao F, Gearhart JM, Goh G, Goodman JM, Grisoni F, Grulke CM, Hartung T, Hirn M, Karpov P, Korotcov A, Lavado GJ, Lawless M, Li X, Luechtefeld T, Lunghini F, Mangiatordi GF, Marcou G, Marsh D, Martin T, Mauri A, Muratov EN, Myatt GJ, Nguyen DT, Nicolotti O, Note R, Pande P, Parks AK, Peryea T, Polash AH, Rallo R, Roncaglioni A, Rowlands C, Ruiz P, Russo DP, Sayed A, Sayre R, Sheils T, Siegel C, Silva AC, Simeonov A, Sosnin S, Southall N, Strickland J, Tang Y, Teppen B, Tetko IV, Thomas D, Tkachenko V, Todeschini R, Toma C, Tripodi I, Trisciuzzi D, Tropsha A, Varnek A, Vukovic K, Wang Z, Wang L, Waters KM, Wedlake AJ, Wijeyesakere SJ, Wilson D, Xiao Z, Yang H, Zahoranszky-Kohalmi G, Zakharov AV, Zhang FF, Zhang Z, Zhao T, Zhu H, Zorn KM, Casey W, Kleinstreuer NC. 2021. CATMoS: Collaborative Acute Toxicity Modeling Suite. Environ Health Perspect 129:47013. https://doi.org/10.1289/EHP8495.

Mansouri K, Kleinstreuer N, Abdelaziz AM, Alberga D, Alves VM, Andersson PL, Andrade CH, Bai F, Balabin I, Ballabio D, Benfenati E, Bhhatari B, Boyer S, Chen J, Consonni V, Farag S, Fourches D, Garcia-Sosa AT, Gramatica P, Grisoni F, Grulke CM, Hong H, Horvath D, Hu X, Huang R, Jeliazkova N, Li J, Li X, Liu H, Manganelli S, Mangiatordi GF, Maran U, Marcou G, Martin T, Muratov E, Nguyen DT, Nicolotti O, Nikolov NG, Norinder U, Papa E, Petitjean M, Piir G, Pogodin P, Poroikov V, Qiao X, Richard AR, Roncaglioni A, Ruiz P, Rupakheti C, Sakkiah S, Sangion A, Schramm KW, Selvaraj C, Shah I, Sild S, Sun L, Taboureau O, Tang Y, Tetko IV, Todeschini R, Tong W, Trisciuzzi D, Tropsha A, Ven Den Driessche G, Varnek A, Wang Z, Wedebye EB, Williams A, Xie H, Zakharov AV, Zheng Z, Judson RS. 2020. CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity. Environ Health Perspect 128(2):027002. https://doi.org/10.1289/EHP5580.

Nelms MD, Karmaus AL, Patlewicz G. 2020. An evaluation of the performance of selected (Q)SARs/expert systems for predicting acute oral toxicity. Comput Toxicol 16:100135. https://doi.org/10.1016/j.comtox.2020.100135.

Pamies D, Leist M, Coecke S, Bowe G, Allen DG, Gstraunthaler G, Bal-Price A, Pistollato F, de Vries RBM, Hogberg HT, Hartung T, Stacey G. 2021. Guidance document on good cell and tissue culture practice 2.0. ALTEX 39(1):30-70. https://doi.org/10.14573/altex.2111011.

Parish ST, Aschner M, Casey W, Corvaro M, Embry MR, Fitzpatrick S, Kidd D, Kleinstreuer NC, Lima BS, Settivari RS, Wolf DC, Yamazaki D, Boobis A. 2020. An evaluation framework for new approach methodologies (NAMs) for human health safety assessment. Reg Toxicol Pharmacol 112:104592. https://doi.org/10.1016/j.yrtph.2020.104592.

Patel V, Amin K, Allen D, Ukishima L, Wahab A, Grodi C, Behrsing H. 2021. Comparison of long-term human precision-cut lung slice culture methodology and response to challenge: an argument for standardization. Altern Lab Anim 49(5):209-222. https://doi.org/10.1177/02611929211061884.

Petersen EJ, Ceger P, Allen DG, Coyle J, Derk R, Garcia-Reyero N, Gordon J, Kleinstreuer N, Matheson J, McShan D, Nelson BC, Patri AK, Rice P, Rojanasakul L, Sasidharan A, Scarano L, Chang X. 2021. U.S. federal agency interests and key considerations for new approach methodologies for nanomaterials. ALTEX 39(2):183-206. https://doi.org/10.14573/altex.2105041.

Petersen E, Nguyen A, Brown J, Elliot J, Clippinger A, Gordon J, Kleinstreuer N, Roesslein M. 2021. Characteristics to consider when selecting a positive control material for an in vitro assay. ALTEX 38(2):365-376. https://doi.org/10.14573/altex.2102111.

Petersen E, Sharma M, Clippinger A, Gordon J, Katz A, Laux P, Leibrock LB, Luch A, Matheson J, Stucki AO, Tentschert J, Bierkandt FS. 2021. Use of cause-and-effect analysis to optimize the reliability of in vitro inhalation toxicity measurements using an air–liquid interface. Chem Res Toxicol 34(6):1370-1385. https://doi.org/10.1021/acs.chemrestox.1c00080.

Prior H, Baldrick P, Beken S, Booler S, Bower N, Brooker P, Brown P, Burlinson B, Burns-Naas LA, Casey W, Chapman M, Clarke D, de Haan L, Doehr O, Downes N, Flaherty M, Gellatly N, Moesgaard SG, Harris J, Holbrook M, Hui J, Jones D, Jones K, Kedar H, Mahl A, Manninen A, McGuire A, Mortimer-Cassen E, Peraza M, Pugsley MK, Richard J, Roberts R, Roosen W, Rothfuss A, Schoenmakers A, Sewell F, Weaver R, Weir L, Wolfreys A, Kimber I. 2020. Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation. Reg Toxicol Pharmacol 113:104624. https://doi.org/10.1016/j.yrtph.2020.104624.

Richard AM, Huang R, Waidyanatha S, Shinn P, Collins BJ, Thillaindarajah I, Grulke CM, Williams AJ, Lougee RR, Judson RS, Houck KE, Shobair M, Yang C, Rathman JF, Yasgar A, Fitzpatrick SC, Simeonov A, Thomas RS, Crofton KM, Paules RS, Bucher JR, Austin CP, Kavlock RJ, Tice RR. 2021. The Tox21 compound library: collaborative chemistry advancing toxicology. Chem Res Toxicol 34(2):189-216. https://doi.org/10.1021/acs.chemrestox.0c00264.

Rooney JP, Choksi NY, Ceger P, Daniel AB, Truax J, Allen DG, Kleinstreuer NC. 2021. Analysis of variability in the rabbit skin irritation assay. Regul Toxicol Pharmacol 122:104920. https://doi.org/10.1016/j.yrtph.2021.104920.

Rovida C, Barton-Maclaren T, Benfenati E, Caloni F, Chandrasekera C, Chesne C, Cronin MTD, De Knecht J, Dietrich DR, Escher SE, Fitzpatrick S, Flannery B, Herzler M, Hougaard Bennekou S, Hubesch B, Kamp H, Kisitu J, Kleinstreuer N, Kovarich S, Leist M, Maertens A, Nugent K, Pallocca G, Pastor M, Patlewicz G, Pavan M, Presgrave O, Smirnova L, Schwarz M, Yamada T, Hartung T. 2020. Internationalization of read-across as a validation new approach method (NAM) for regulatory toxicology. ALTEX 37(4):579-606. https://doi.org/10.14573/altex.1912181.

Sedykh AY, Shah RR, Kleinstreuer NC, Auerbach SS, Gombar VK. 2021. Saagar - a new, extensible set of molecular substructures for QSAR/QSPR and read-across predictions. Chem Res Toxicol 34(2):634-640. https://doi.org/10.1021/acs.chemrestox.0c00464.

Smith MT, Guyton KZ, Kleinstreuer N, Borrel A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson WH, Houck KA, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden M. 2020. The key characteristics of carcinogens: relationship to the hallmarks of cancer, relevant biomarkers, and assays to measure them. Cancer Epidemiol Biomarkers Prev 29:1887-1903. https://doi.org/10.1158/1055-9965.epi-19-1346.

Sullivan K, Allen DG, Clippinger AJ, Wilson DM, Edwards SW, Glover K, Mansouri K, Settivari R, Wijeyesakere S, Casey W. 2021. Mind the gaps: prioritizing activities to meet regulatory needs for acute systemic lethality. ALTEX 38(2):327-335. https://doi.org/10.14573/altex.2012121.

Tan YM, Barton HA, Boobis A, Brunner R, Clewell H, Cope R, Dawson J, Domoradzki J, Egeghy P, Gulati P, Ingle B, Kleinstreuer N, Lowe K, Lowit A, Mendez E, Miller D, Minucci J, Nguyen J, Paini A, Perron M, Phillips K, Qian H, Ramanarayanan T, Sewell F, Villanueva P, Wambaugh J, Embry M. 2021. Opportunities and challenges related to saturation of toxicokinetic processes: implications for risk assessment. Reg Toxicol Pharmacol 127:105070. https://doi.org/10.1016/j.yrtph.2021.105070.

Tandon A, Howard B, Ramaiahgari S, Maharana A, Ferguson S, Shah R, Merrick BA. 2021. Deep learning image analysis of high-throughput toxicology assay images. SLAS Discov 27(1):29-38. https://doi.org/10.1016/j.slasd.2021.10.014.

Wei Z, Liu X, Ooka M, Zhang L, Song MJ, Huang R, Kleinstreuer NC, Simeonov A, Xia M, Ferrer M. 2020. Two-dimensional cellular and three-dimensional bio-printed skin models to screen topical-use compounds for irritation potential. Front Bioeng Biotechnol 8:109. https://doi.org/10.1021/acs.chemrestox.9b00228.

A searchable list of NICEATM and ICCVAM abstracts is available on the NTP website.

Abedini J, Bell S, Chang X, Choksi N, Cook B, Daniel AB, Hines D, Karmaus AL, Mansouri K, Allen D, Kleinstreuer N. 2021. NICEATM computational tools and data resources [Abstract]. Presented at the 19th International Workshop on (Quantitative) Structure-Activity Relationships in Environmental Health Sciences; 7-10 June 2021.

Abedini JA, Bell S, Chang X, Cook BT, Karmaus AL, Mansouri K, Allen DG, Kleinstreuer NC. 2021. NICEATM computational tools and resources supporting alternative test method development and evaluation [Abstract 2542]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Abedini J, Bell S, Mansouri K, McAfee E, Phillips J, Chang X, Karmaus AL, Cook B, Allen D, Casey W, Kleinstreuer N. 2020. NICEATM computational tools and resources supporting alternative test method development and evaluation [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Abedini J, Cook B, McAfee E, Phillips J, Bell S, Rooney J, Allen D, Casey W, Kleinstreuer N. 2021. Utilizing ICE tools to expand chemical knowledge: Chemical Quest [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Adams VH, Reinke EN, Holden LA, LaScala JJ. 2020. In silico and in vitro analysis of 4-4'-methylenedianiline replacements [Abstract 3393]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Allen DG. 2020. Regulatory landscape and key considerations for establishing inhalation reference data [Continuing Education course presentation]. Presented as part of the 2020 Annual Meeting of the Society of Toxicology.

Allen DG. 2021. Retrospective analysis of dermal triple pack data [Abstract P225]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Allen DG, Rooney JP, Choksi N, Ceger P, Daniel A, Karmaus A, Strickland J, To K, Truax J, Casey W, Kleinstreuer N. 2021. Establishing confidence in NAMs: considering variability in reference test methods [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Allen DG, Rooney JP, Kleinstreuer NC, Lowit A, Perron M. 2021. Retrospective analysis of dermal absorption triple pack data [Abstract 2757]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Bell S. 2020. Integrated Chemical Environment [Continuing Education course presentation]. Presented as part of the 2020 Annual Meeting of the Society of Toxicology.

Bell S. 2021. Improving alternative method adoption through tools and resources to support community knowledge [Abstract 1008]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Bell S, Abedini J, Ceger P, Karmaus A, Daniel A, Choksi N, Rooney J, Allen D, Kleinstreuer N. 2020. Providing insight into chemical activity through data curation and assay annotation [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Bell S, Ceger P, Fostel J, Holmgren S, Masci AM, Allen D, Casey W, Kleinstreuer N. 2021. Accelerating adoption of NAMs with FAIR principles [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Bell S, Mansouri K, Phillips J, Chang X, Abedini J, Karmaus AL, Lea I, Rai R, Allen DG, Casey W, Kleinstreuer NC. 2020. NICEATM computational tools and resources supporting alternative test method development and evaluation [Abstract 2976]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Bishop P, Mansouri K, Allen D, Casey W, Kleinstreuer N. 2021. Acute oral toxicity predictions for environmental risk assessment [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Borba J, Braga R, Alves V, Muratov E, Kleinstreuer N, Tropsha A, Andrade C. 2020. Pred-Skin: a web portal for accurate prediction of human skin sensitizers [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Britton K, Korest D, Judson R, Jarema K, Coutros K, Wetmore B, Hill B, Hunter D, Olin J, Padilla S. 2020. Developmental toxicity assessment of a library of per- and polyfluoroalkyl substances in zebrafish (Danio rerio) embryos/larvae [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Casey W. 2020. Modernizing the NTP carcinogenicity testing program [Abstract]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Casey W. 2021. Incorporating NAMs into the DNTP carcinogenicity testing program [Abstract 1196]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Casey W. 2021. Modernizing the NTP’s carcinogenicity testing program [Abstract 11]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Casey W. 2021. Organ-on-a-chip validation efforts: challenges and lessons learned [Continuing Education course presentation]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Ceger P. 2021. Retrospective evaluation of the acute fish toxicity test for pesticide registration [Abstract P268]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Ceger P, Allen DG, Choksi N, Daniel A, Eckel W, Hamm J, Johnson T, Kleinstreuer NC, Lowit M, Sprankle C, Truax J, Odenkirchen E. 2021. Retrospective evaluation of the acute fish toxicity test for pesticide registration [Abstract 2324]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Ceger P, Garcia-Reyero N, Allen D, Arnold E, Bloom R, Brennan JC, Clarke C, Eisenreich K, Fay K, Hamm J, Henry PFP, Horak K, Hunter W, Judkins D, Klein P, Kleinstreuer N, Koehrn K, LaLone CA, Laurenson JP, Leet JK, Lowit A, Lynn SG, Norberg-King T, Perkins EJ, Petersen EJ, Rattner BA, Sprankle CS, Steeger T, Warren JE, Odenkirchen E. 2021. Determination of ecotoxicity testing needs among selected U.S. federal agencies [Abstract]. Presented at SETAC North America 2021; 14-18 November 2021.

Chang X. 2021. Toxicokinetic models for QIVIVE and consideration of uncertainty [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Chang X. 2021. In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues [Abstract 442]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Chang X, Lumen A, Palmer J, Lee U, Ceger P, Donley B, Bell S, Allen D, Casey W, Kleinstreuer NC. 2020. In vitro to in vivo extrapolation for developmental toxicity potency of valproate analogues [Abstract P15]. Presented at the 60th Annual Meeting of the Society for Birth Defects Research and Prevention; 25 June-2 July 2020.

Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley E, Bell S, Allen D, Kleinstreuer N. 2020. In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley E, Bell S, Allen D, Casey W, Kleinstreuer N. 2020. In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues [Abstract 1612]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Chang X, Palmer J, Donley E, Allen D, Casey W, Kleinstreuer N. 2021. In vitro to in vivo extrapolation for developmental toxicity potency of selected Tox21 chemicals [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Choksi N. 2021. Developing a defined approach for eye irritation testing [Abstract P505]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen DG. 2020. Developing a defined approach for eye irritation testing [Abstract 2198]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen D. 2020. Testing of agrochemical formulations using in vitro and ex vivo eye irritation test methods [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Cook B, Abedini J, Bell S, McAfee E, Phillips J, Allen D, Kleinstreuer N. 2021. Chemical exploration: providing biological context for NAMs [Abstract]. Presented at the 19th International Workshop on (Quantitative) Structure-Activity Relationships in Environmental Health Sciences; 7-10 June 2021.

Cook B, Abedini J, Bell S, McAfee E, Phillips J, Allen D, Kleinstreuer N. 2020. Chemical exploration: identifying bioactivity with the use of structural features [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Cook B, Abedini JA, Bell S, McAfee E, Phillips J, Rooney JP, Allen DG, Kleinstreuer NC. 2021. Providing context for chemical effects through bioactivity and consumer use [Abstract 2541]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Daniel AB, Abedini JA, Bell S, Chang X, Cook B, Karmaus AL, Hines DE, McAfee E, Phillips J, Rooney JP, Allen DG, Kleinstreuer NC. 2021. Updates to the Integrated Chemical Environment: expanding tools and data to support toxicity assessments [Abstract 2958]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Farcas MT, Stefaniak AB, McKinney W, Knepp AK, Bowers L, Mandler WK, Kashon M, Battelli L, Stueckle TA, Orandle M, Winn A, Friend SA, Jackson SR, Qi C, Hammond DR, Mercer R, LeBeouf R, Burns D, Ranpara A, Thomas TA, Matheson J, Castranova V, Qian Y. 2020. Toxicological evaluation of acrylonitrile butdiene styrene (ABS) 3D printer emissions [Abstract 1679]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Fitzpatrick S. 2020. In vitro microphysiological systems: advancing regulatory science through innovation [Abstract]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Fitzpatrick S. 2021. Developing performance based qualification criteria for organs on a chip [Abstract 946]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Fitzpatrick S. 2021. Implementing new testing approaches at the US Food and Drug Administration [Continuing Education course presentation]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Foster C. 2021. Standardizing developmental toxicology study extractions using automated application of ontologies [Abstract P576]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Foster C, Wignall J, Kovach S, Trgovcich J, Varghese A, Rochester J, Stout M, Kleinstreuer NC. 2020. Automated applications of ontologies to standardize developmental toxicology study extraction [Abstract 25]. Presented at the 60th Annual Meeting of the Society for Birth Defects Research and Prevention; 25 June-2 July 2020.

Gombar V, Sedykh A, Ross A, Casey W, Shah R. 2021. OrbiTox: a translational discovery platform for concerted view and analysis of big data [Abstract 2802]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Gombar V, Sedykh A, Ross A, Witt K, Shah R, Casey W. 2021. OrbiTox: a translational discovery platform for concerted view and analysis of multi-domain data [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Gordon JD, Uhl R, Toman B, Elliot J, Petersen E. 2020. Using a measurement science approach to increase confidence in the EASA skin sensitization assay [Abstract 1417]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Gordon JD, Uhl R, Toman B, Elliot J, Petersen E. 2020. EASA skin sensitization assay development: using a measurement science approach to increase confidence [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Guo X, Seo J, Wu Q, Manjanatha MG, Mei N. 2021. Performance of metabolically competent HepaRG cells for genotoxicity testing: a comparison between three human hepatic cells using the high-throughput micronucleus and comet assays [Abstract 2806]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Hamm J. 2021. Performance of the GHS mixtures equations for predicting acute oral toxicity [Abstract P572]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Hamm J, Allen DG, Ceger P, Flint T, Kleinstreuer NC, O'Dell L, Tao JJ, Lowit A. 2021. Predicting oral acute toxicity using the GHS additivity equation [Abstract 2345]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Henry TR, Salazar KD, Hayes MP, Kennedy W, Keene AM, Jarabek AM, Price OT, Moors S, Jovanovich L, Rose JL, Tveit A, Tremblay RT, Becker RA, Osman-Sypher S, McMullen PD, Slattery SD, Irwin W, Odin M, Melia J, Sharma M, Clippinger AJ, Stucki A, Stedeford T. 2021. Surfactants category: an integrated approach to testing and assessment (IATA) including new approach methods (NAMs) for assessing inhalation risks under the Toxic Substances Control Act (TSCA) [Abstract 2583]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Hill BN, Hunter DL, Padilla S. 2020. Zebrafish larval locomotor activity is depressed by lack of swim bladder inflation or dimethyl sulfoxide [Abstract 1461]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Hilton GM, Akerman G, Baldassari J, Battalora M, Buesen R, Clippinger AJ, Geter D, Lowit A, Melching-Kollmuss S, Kormos T, Papineni S, Peffer RC, Williamson Riffle B, Ryan N, Visconti N, Wolf DC. 2020. Rethinking carcinogenicity assessment for agrochemicals [Abstract 2200]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Hines D, Bell S, Chang X, Mansouri K, Allen D, Casey W, Kleinstreuer N. 2021. Computational support of pharmacokinetic models and in vitro to in vivo extrapolation [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Jarabek AM, Stedeford T, Ladics GS, Price OT, Tveit A, Hayes MP, Tremblay RT, Snyder SA, Salazar KD, Osman-Sypher S, Irwin W, Odin M, Melia J, Carlson-Lynch H, Sharma M, Clippinger AJ, Stucki AO, Henry TR. 2021. Poorly soluble, low toxicity (PSLT) polymer category: an integrated approach to testing and assessment (IATA) including new approach methods (NAMs) under the Toxic Substances Control Act (TSCA) [Abstract 2593]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Kaldhone P, Yan J, Chen T, Manjanatha M. 2020. Glyphosate safety assessment through Ames test [Abstract 1668]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Kang JC, Valerio L. 2020. Investigating DNA adduct formation by flavor chemicals and tobacco byproducts in electronic nicotine delivery system (ENDS) using in silico approaches [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Karmaus AL 2021. Comparing and interpreting Tox21 data analysis approaches [Abstract 1000]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Karmaus AL. 2021. Interpreting the Tox21 data analysis methods toward a consensus [Continuing Education course presentation]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Karmaus AL. 2021. Rat acute systemic toxicity testing: evaluating reproducibility and inherent variability [Abstract P232]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Karmaus A, Rooney J, Ceger P, Abedini J, Phillips J, Bell S, Allen D, Kleinstreuer N. 2021. Annotating and visualizing in vitro data to gain context [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Kleinstreuer NC. 2020. Computational crowdsourcing: leveraging global expertise to predict toxicity [Abstract]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Kleinstreuer NC. 2020. What do computational toxicology tools offer? [Continuing Education course presentation]. Presented as part of the 2020 Annual Meeting of the Society of Toxicology.

Kleinstreuer NC. 2020. Establishing international test guidelines for skin sensitization: predictive capacity and applicability domain of nonanimal-defined approaches [Abstract]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Kleinstreuer NC. 2021. Automated approaches to anchoring alternatives [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Kleinstreuer NC. 2021. Applying in vitro to in vivo extrapolation to NAM-derived PODs [Abstract 49]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. Building an AOP-driven defined approach guideline [Abstract 47]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. High-throughput screening to predict HERG inhibition [Abstract P577]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. International regulatory progress on nonanimal approaches for skin sensitization [Abstract 1283]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Kleinstreuer NC. 2021. The intersection of scientific advances and regulatory needs [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Kleinstreuer NC. 2021. Introduction to skin sensitisation NAMs and defined approaches [Abstract]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. A North American regulatory perspective on skin sensitization risk assessment [Abstract 48]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. "Proof in animals": has journal editorial policy fallen behind advances in human-based approaches [Abstract]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. Systematic evidence mapping of research on environmental exposures and cardiovascular disease [Abstract P578]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Krishna S, Berridge BR, Kleinstreuer N. 2020. Predicting putative cardiotoxic chemicals using Tox21 qHTS data [Abstract 3131]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Krishna S, Beverley B, Walker V, Kleinstreuer N, Rooney A. 2021. Systematic evidence mapping of research on environmental exposures and cardiovascular disease [Abstract 2791]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Krishna S, Beverley B, Walker V, Kleinstreuer N, Rooney A. 2021. Systematic evidence mapping of research on environmental exposures and cardiovascular disease [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Krishna S, Borrel A, Huang R, Zhao J, Xia M, Kleinstreuer N. 2021. High-throughput screening to predict hERG inhibition [Abstract 2561]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Krishna S, Borrel A, Huang R, Zhao J, Xia M, Kleinstreuer N. 2021. High-throughput screening to predict hERG inhibition [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Lavrich K, Ramiahgari S, Urbano N, Merrick BA, Ferguson S. 2020. Modeling inter-individual susceptibility in toxicological screening using 3D spheroid primary human hepatocyte cultures [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Li X, He X, Chen S, Guo X, Bryant MS, Guo L, Manjanatha MG, Mei N. 2021. The genotoxicity of pyrrolizidine alkaloids is mediated by CYP3A in metabolically competent TK6 cell lines [Abstract 2804]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Lowit A. 2021. Recent progress toward reducing animal use and adopting new approach methods [Abstract 1134]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Lowit M, Ceger P, Allen D, Arnold E, Choksi N, Daniel A, Hamm J, Judkins D, Kleinstreuer N, Montague B, Sprankle C, Truax J, Odenkirchen E. 2020. Exploring ways to reduce animal testing in support of the registration of pesticides by the U.S. Environmental Protection Agency [Abstract]. Presented at SETAC North America 2020; 15-19 November 2020.

Lowit M, Ceger P, Allen D, Choksi N, Daniel A, Eckel, W., Hamm J, Johnson, T., Kleinstreuer N, Sprankle C, Truax J, Odenkirchen E. 2021. Applying the 3Rs to Reduce Animal Testing in Support of the Registration of Pesticides by the U.S. Environmental Protection Agency [Abstract]. Presented at SETAC Europe 2021; 3-6 May 2021.

Lowit M. 2021 Exploring Ways to Reduce Animal Testing in a Regulatory Context. [Abstract]. Presented at SETAC Europe 2021; 3-6 May 2021.

Mansouri K. 2021. OPERA, an open-source and open-data suite of QSAR models [Abstract P508]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Mansouri K, Chang X, Allen D, Casey W, Kleinstreuer N. 2021. QSAR models supporting toxicokinetic modeling and in vitro to in vivo extrapolation [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Mansouri K, Chang X, Judson R, Williams A, Allen DG, Kleinstreuer NC. 2021. OPERA models for ADME properties and toxicity endpoints [Abstract 2543]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Mansouri K, Karmaus AL, Fitzpatrick J, Patlewicz G, Pradeep P, Allen DG, Casey W, Kleinstreuer NC. 2020. Collaborative modeling project for predicting acute oral toxicity [Abstract 2060]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N. 2020. Collaborative modeling project for predicting acute oral toxicity (CATMoS) [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N. 2020. International computational modeling collaborations for predictive toxicology [Abstract]. Presented at SETAC North America 2020; 15-19 November 2020.

Mansouri K, Grulke C, Judson R, Richard A, Williams A, Kleinstreuer N. 2021. Open-source QSAR-ready chemical structure standardization workflow [Abstract]. Presented at the 19th International Workshop on (Quantitative) Structure-Activity Relationships in Environmental Health Sciences; 7-10 June 2021.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N. 2021. Collaborative modeling project for predicting acute oral toxicity (CATMoS) [Abstract]. Presented at the 19th International Workshop on (Quantitative) Structure-Activity Relationships in Environmental Health Sciences; 7-10 June 2021.

Martin MM, Baker NC, Boyes WK, Carstens KE, Culbreth ME, Gilbert ME, Harrill JA, Nyffeler J, Padilla S, Paul-Friedman K, Shafer TJ. 2021. An expert-driven literature review of “negative” reference chemicals for developmental neurotoxicity (DNT) assay evaluation [Abstract 2554]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Medlock Kakaley E, Cardon M, Evans N, Bradley P, Iwanowicz L, Gray E, Hartig P, Wilson V. 2020. In vitro bioassay and screening model for pre- and post-distribution for chicago-area treated waters [Abstract 1889]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Mumtaz MM, Pohl HR. 2020. Joint toxicity assessment of perfluoroalkyl substances (PFAS) mixtures [Abstract 2820]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Ooka M, Zhao J, Huang R, Witt K, Ferguson S, Smith-Roe S, Simeonov A, Xia M. 2021. Profiling Tox21 compounds that activate p53 signaling after metabolic activation [Abstract 2761]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Petersen E, Sharma M, Clippinger A, Gordon J, Katz A, Laux P, Leibrock L, Luch A, Matheson J, Stucki A, Tentschert J, Bierkandt F. 2021. Use of cause-and-effect analysis to optimize the reliability of in vitro inhalation toxicity measurements using an air-liquid interface [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Rahman A, Svoboda D, Bushel PR, Berridge BR, Auerbach SS. 2020. Weighted gene coregulation network analysis (wgcna) to decipher temporal dynamics in cardiotoxicity [Abstract 3102]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Rooney JP. 2021. Variability in the rabbit skin irritation assay [Abstract P509]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Rooney J, Abedini J, Bell S, Chang X, Cook B, Ceger P, Hines D, Karmaus A, McAfee E, Phillips J, Allen D, Casey W, Kleinstreuer N. 2021. Building confidence in alternative methods through ICE [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Rooney JP, Choksi N, Ceger P, Daniel A, Truax J, Rai R, Kleinstreuer N, Allen D. 2020. Variability in the rabbit skin irritation assay [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Rooney JP, Choksi N, Ceger P, Daniel AB, Truax J, Allen DG, Kleinstreuer NC. 2021. Variability in the rabbit skin irritation assay [Abstract 2760]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Rooney JP, Choksi N, Rai R, Allen DG, Kleinstreuer NC, Casey W. 2020. Variability in the rabbit skin irritation assay [Abstract 1415]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Rooney J, Lizarraga L, Yamada T, Allen D, Babich M, Daniel A, Fitzpatrick S, Garcia-Reyero N, Gordon J, Hakkinen P, Karmaus A, Kleinstreuer N, Matheson J, Mumtaz M, Rua D, Ruiz P, Scarano L, Volarath P, Patlewicz G. 2020. ICCVAM Read-Across Workgroup: towards guiding principles for read-across applications [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Ruiz P, Boone S, Mumtaz MM. 2020. Advantage of read-across and pharmacokinetics modeling for the exposure assessment of persistent organic pollutants [Abstract 2949]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Sedykh A. 2021. Mixture-based QSAR models of ocular toxicity for regulatory hazard categories [Abstract P230]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Sprankle C. 2021. Effective user support documentation for a toxicological data resource: ICE as a case study [Abstract P513]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Strickland J. 2021. Application of defined approaches for skin sensitization to agrochemical products [Abstract P511]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Strickland J. 2021. International regulatory needs for acute toxicity data [Abstract P586]. Presented at the 11^th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Strickland J, Allen DG, Api A, Gordon J, Kleinstreuer NC, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M. 2020. Classification of human reference data for skin sensitization [Abstract 1872]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Strickland J, Allen D, Api AM, Gordon J, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M. 2020. Human reference database for skin sensitization [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Strickland J, Allen D, Api AM, Gordon J, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M. 2021. Compilation and characterization of a human skin sensitization data set [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Strickland J, Daniel AB, Allen DG, Kleinstreuer NC, Haugabrooks E. 2021. International regulatory needs for acute toxicity data [Abstract 2341]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Strickland J, Truax J, Corvaro M, Settivari R, Henriquez J, McFadden J, Gulledge T, Johnson V, Gehen S, Germolec D, Allen D, Kleinstreuer N. 2021. Skin sensitization testing of mixtures without animals [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Tan C, Lowit A, Embry M. 2020. Applications of physiologically based pharmacokinetic (PBPK) modeling in regulatory risk assessment for pesticides [Abstract 1539]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Tandon A, Maharana A, Howard B, Ramaiahgari S, Dunlap P, Rice J, Merrick A, DeVito M, Ferguson S, Shah R. 2021. Toward automation of high-throughput toxicology assay image analysis using deep learning [Abstract 2977]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

You D, Behl M, Choi T, Balik-Meisner M, Mav D, Phadke D, Shah R, Harrill A. 2020. Molecular assessment of interindividual variability in susceptibility to developmental neurotoxicity of methyl mercury using diversity outbred neural progenitor cells [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Lenox K. January 2020. Chronic inflammation needs focused research to reduce disease. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2020/1/papers/inflammation/index.htm.

Sprankle C. January 2020. Moving away from animal-based antibodies. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2020/1/science-highlights/cell-based-antibodies/index.htm.

Sprankle C. July 2020. Reductions in animal testing celebrated at national meeting. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2020/7/science-highlights/nonanimal-testing/index.htm.

Sprankle C. September 2020. Animal testing alternatives advanced by 16 government agencies. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2020/9/science-highlights/animal-testing/index.htm.

Sprankle C. October 2020. Nonanimal safety testing requires data quality, measures of success. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2020/10/science-highlights/safety-testing/index.htm.

Sprankle C. December 2020. Department of Veterans Affairs joins effort to reduce animal testing. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2020/12/science-highlights/va/index.htm.

Sprankle C. March 2021. Organs-on-a-chip for COVID-19 research group led by NTP center. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2021/3/science-highlights/organ-chip/index.htm.

Sprankle C. May 2021. New predictive model may speed toxicity screens, reduce animal use. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2021/5/papers/predictive-toxicity/index.htm.

Sprankle C. July 2021. Animal replacement accomplishments draw broad interest. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2021/7/science-highlights/nonanimal-methods/index.htm.

Sprankle C. August 2021. New chemical testing approach will help to replace animal use. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2021/8/science-highlights/nonanimal-testing/index.htm.

Sprankle C. November 2021. Agencies advised on reducing animal testing, embracing alternatives. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2021/11/science-highlights/nonanimal-methods/index.htm.

Weaver J. March 2021. Computational toxicology featured in special journal issue. Environmental Factor [Internet]. [cited 30 Mar 2022] Available from: https://factor.niehs.nih.gov/2021/3/papers/comp-tox/index.htm.