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ICCVAM Biennial Report 2020-2021

Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods

Web Application to Apply Skin Sensitization Defined Approaches to User Data

In June 2021, OECD issued Guideline 497, Defined Approaches on Skin Sensitisation, the first internationally harmonized guideline to describe a non-animal approach to predict skin sensitization potential. NICEATM scientists are developing an interactive web application that computationally applies the defined approaches outlined in Guideline 497 through a user-friendly interface. The user uploads data from the test methods used in the defined approach to the web application, which then generates skin sensitization predictions for the user’s chemicals of interest. The user selects the analysis variables, and the application dynamically provides feedback about the user’s data set to identify problematic data values. The application is still in development and will be available on the NTP website in 2022.