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ICCVAM Biennial Report 2020-2021

Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods


Many ICCVAM member agencies are developing new technologies and resources intended to replace the use of animals for chemical safety testing. These include new platforms such as microphysiological systems and data resources to support the development of predictive models and adverse outcome pathways.

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Assay Development

ICCVAM member agencies are developing in vitro assays for a variety of endpoints.

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Computational Tools Development

ICCVAM member agencies are developing computational tools to predict toxicity.

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Data Resources

ICCVAM member agencies compile toxicity data to support new method development and assessment.

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Tox21 Cross-partner Projects

The four Tox21 participant groups are collaborating on more efficient approaches to predict how chemicals may affect human health.