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ICCVAM Biennial Report 2020-2021

Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods

Draft Risk Assessment for Chlorothalonil

In a May 2021 Federal Register notice (86 FR 27593), EPA announced availability of draft human health and/or ecological risk assessments for several pesticides. EPA accepted public comment on the risk assessments through September 2021.

One of the pesticides covered by this announcement was the fungicide chlorothalonil, which was the subject of a case study to use an in vitro model to develop an inhalation risk assessment. The case study will be published in an OECD guidance document in 2022. Data from the in vitro model were used in conjunction with human dosimetry modeling to evaluate human inhalation risk, which is included in the document “Chlorothalonil: Revised Human Health Draft Risk Assessment for Registration Review.” This and other documents relevant to the chlorothalonil evaluation are available in a docket on Regulations.gov.