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Management Status Report: Reference 17

Long-Term Exposure Studies for Which Technical Reports Were Not Prepared
CHEMICAL NAME
SYNONYM(S)		 PRIMARY
CASRN		 ROUTE SPECIES COMMENTS FOOTNOTE
REFERENCE
Actinomycin D
Actinomycin C1 		50-76-0 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Agaritine
5-(2-(4-Hydroxymethyl)phenyl)hydrazide)-L-Glutamic acid (9CI) 		2757-90-6 WATER M4 RESULTS REPORTED IN JOURNAL ARTICLE E
3-Amino-9-ethylcarbazole
9-Ethyl-9H-carbazol-3-amine 		132-32-1 FEED R2 M3
Amsacrine
Acridinylanisidide
N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide 		51264-14-3 IP/IJ R2 M3
L-Arginine Glutamate
L-Arginine L-glutamate
L-Glutamic acid compd. with L-Arginine (1:1)
Modumate 		4320-30-3 FEED R2 M1
Azathioprine
NSC 39084 		446-86-6 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Benzyl chloride
(Chloromethyl)benzene 		100-44-7 GAV R2 M3 RESULTS REPORTED IN JOURNAL ARTICLE H
1,3-bis(Chloroethyl)-1-nitrosourea
BCNU
NSC 409962 		154-93-8 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
bis(Chloromethyl) ether
Oxybis(chloromethane) 		542-88-1 INHAL R8 H1
1,3-Butadiene
alpha,gamma-Butadiene 		106-99-0 INHAL M3 Q
Calcium chromate
Chromic acid (H2CrO4), calcium salt (1:1) 		13765-19-0 INHAL R8 H1
Carbon tetrachloride
Benzinoform
Freon 10
Halon 1040
Tetrachloromethane 		56-23-5 GAV R1 M3
Chlorambucil
4-(Bis(2-chloroethyl)amino)benzenebutanoic acid 		305-03-3 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Chloromethyl methyl ether
Chloromethoxymethane 		107-30-2 INHAL R8 H1
Chromium
Chrome
Chromium Inorganic, Hexavalent 		7440-47-3 INHAL R8 H1
Cyclohexanone
Pimelin ketone 		108-94-1 WATER R2 M3 RESULTS REPORTED IN JOURNAL ARTICLE J
Cyclophosphamide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide 		50-18-0 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Cytarabine
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
Cytosine arabinoside 		147-94-4 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Cytoxal alcohol
Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, compd .with cyclohex anamine (1:1) (9CI)		 4465-94-5 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Dacarbazine
DIC
1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)- 		4342-03-4 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Daunomycin
Rubomycin C 		20830-81-3 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
o,p'-DDD
1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene
o,p'-Dichlorodiphenyldichloroethane 		53-19-0 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Dibromodulcitol
1,6-Dibromo-1,6-dideoxy-D-galactitol 		10318-26-0 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Dibromomannitol
1,6-Dibromo-1,6-dideoxy-D-mannitol 		488-41-5 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Dichloromethotrexate
N-(3,5-Dichloro-4-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)glutamic acid 		528-74-5 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Dimethylcarbamoyl chloride
Carbamic chloride, dimethyl-
Dimethylcarbamyl chloride 		79-44-7 INHAL R8 H1
Dimethyl hydrazine (DMH)
Hydrazine, 1,1-dimethyl- 		57-14-7 INHAL M1
1,2-Dimethylhydrazine 2HCl
N,N'-Dimethylhydrazine dihydrochloride 		306-37-6 FEED R2
Epichlorhydrin
alpha-Epichlorohydrin
Oxirane, (chloromethyl)- 		106-89-8 INHAL R8
Furan
Oxacyclopentadiene 		110-00-9 GAV RC C10119
Guanazole
1H-1,2,4-triazole-3,5-diamine (9CI) 		1455-77-2 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Hexanamide
N-Hexamide 		628-02-4 FEED R2 M1
Hydroxyurea
SQ 1089 		127-07-1 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Insertional Mutagenesis - Definitive Vector Study
 INSERTMUT3 IV M1
Lomustine
N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea (9CI) 		13010-47-4 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Melphalan
4-(Bis(2-chloroethyl)amino)-DL-phenylalanine 		148-82-3 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
6-Mercaptopurine
1,7-Dihydro-6H-purine-6-thione (9CI) 		50-44-2 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Merphalan
4-(Bis(2-chloroethyl)amino)-DL-phenylalanine 		531-76-0 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Methotrexate
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid (9CI) 		59-05-2 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Methyl CCNU
N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea (9CI)
(1-Nitrosourea-1-(2-chloroethyl)-3-(4-methylcyclohexyl) 		13909-09-6 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Methyl isocyanate
Isocyanatomethane (9CI) 		624-83-9 INHAL NA R
6-Methylmercaptopurine ribonucleoside
6-(Methylthio)-9-beta-D-ribofuranosyl-9H-purine 		342-69-8 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
2-Methyl-1-nitroanthraquinone
2-Methyl-1-nitro-9,10-Anthracenedione (9CI) 		129-15-7 FEED M3 RESULTS REPORTED IN JOURNAL ARTICLE D
Mitomycin C
Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1 ,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))- (9CI)		 50-07-7 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Mouse ageing study
 MOUSEAGE M3 RESULTS REPORTED IN JOURNAL ARTICLE O
Nitrofurazone
2((5-Nitro-2-furanyl)methylene)hydrazinecarboxamide 		59-87-0 FEED M3 RESULTS TO BE PUBLISHED.
NTP 90 diet study
 DIET90 FEED M3 NA N
NTP 91/92 diet study
 DIET9192 FEED R2 N
Polyurethane
Urethane polymers 		9009-54-5 INHAL R8 H1
Prednisone
Deltacortisone
17,21-Dihydroxy-pregna-1,4-diene-3,11,20-trione (9CI) 		53-03-2 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Procarbazine hydrochloride
Natulan hydrochloride
N-(1-Methylethyl)-4-((2-methylhydrazino)benzamide monohydrochloride (9CI) 		366-70-1 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Rotenone
(2R-(2-alpha,6Aalpha,12Aalpha))-1,2,12,12A-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-(1 )benzopyrano(3,4-B)furo(2,3-H)(1)benzopyran-6(6aH)-one (9CI)		 83-79-4 IP/IJ R2 RESULTS REPORTED IN NCTR REPORT M
Sodium Fluoride
Sodium fluoride (NaF) 		7681-49-4 WATER R2 Supplemental study P
Streptozotocin
2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucose (9CI)
Streptozoticin 		18883-66-4 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Styrene oxide
Phenyloxirane (9CI) 		96-09-3 GAV R2 M3 RESULTS REPORTED IN JOURNAL ARTICLE K
p-Tolylurea
(4-Methylphenyl)urea (9CI) 		622-51-5 FEED R2 M1
Uracil mustard
5-(Bis(2-chlorethyl)amino)-2,4(1H,3H)pyrimidinedione (9CI) 		66-75-1 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Vinblastine
Vincaleukoblastine (9CI) 		865-21-4 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Vincristine
22-Oxovincaleukoblastine (9CI) 		57-22-7 IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Wollastonite calcium silicates
Wollastonite (9CI) 		13983-17-0 INHAL R2 RESULTS REPORTED IN JOURNAL ARTICLE I
A
EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
C10119
Tryndyak V, de Conti A, Doerge DR, Olson GR, Beland FA, Pogribny IP. Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study. Arch Toxicol. 2016;1-11
D
ASK Murthy, JR Baker, ER Smith, GG Wade, Development of Hemangiosarcomas in B6C3F1 Mice Fed 2-Methyl-1-Nitroanthraquinone. Int. J. Cancer 19:117-121 (1977)
E
B Toth, CR Raha, L Wallcave, D Nagel, Attempted Tumor Induction with Agaritine in Mice. Anticancer Res 1:255-258 (1981)
H
W Lijinsky, Chronic Bioassay of Benzyl Chloride in F344 Rats and (C57BL/6JXBALB/C)F1 Mice. J Natl Cancer Inst. 1986 Jun;76(6):1231-6.
I
McConnell EE, Hall L, Adkins B Jr., Studies on the Chronic Toxicity (Inhalation) of Wollastonite in Fischer 344 Rats. Inhalation Toxicology 3:323-337 (1991).
J
Lijinsky W, RM Kovatch, Chronic Toxicity Study of Cyclohexanone in Rats and Mice. J Natl Cancer Inst. 1986 Oct;77(4):941-9.
K
W Lijinsky. Rat and Mouse Forestomach Tumors Induced by Chronic Oral Administration of Styrene Oxide. J Natl Cancer Inst. 1986 Aug;77(2):471-6.
M
Tumorogenic Potential of Rotenone and its Specificity for Mammary Tissue, published by National Center for Toxicological Research (NCTR Experiment No. 216). Call NCTR (501-543-7115) for availability of document.
N
GN Rao, J Edmondson and MR Elwell. Influence of dietary fat and fiber on growth and tumor incidences in Fischer 344 rats (presented in an abstract at the 33rd annual meeting of the Society of Toxicology in March 1994). Toxicologist 14(1):303, 1994.
O
GN Rao. Growth, Body Weight Patterns, and life Span of the B6C3F1 Mouse. Pathology of the Mouse (R. Maronpot, Ed.) Cache River Press, Vienna, IL. (1999)
P
Supplemental 2-Year Sodium Fluoride Male Rat Study (available on NTP website https://ntp.niehs.nih.gov/go/16389)
Q
Bucher JR, Melnick RL, and Hildebrandt PK. Lack of Carcinogenicity in Mice Exposed Once to High Concentrations of 1,3-Butadiene. J. Nat. Cancer Inst 85: 1866-1867 (1993).
R
Bucher JR, Uraih LC, Hildebrandt PK, Sauer RM, Seely JC. Carcinogenicity and pulmonary pathology associated with a single 2-hour inhalation exposure of laboratory rodents to methyl isocyanate. J Natl Cancer Inst. 1989 Oct 18;81(20):1586-7. doi: 10.1093/jnci/81.20.1586