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Testing Status of Formaldehyde 10002-S

CASRN: 50-00-0

Formula: C-H2-O

Synonyms/Common Names

  • Formalin

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C02799)  Completed 
    • Mice: B6C3F1
  • 2 weeks (Inhalation)  (C10002)  Completed 
    • Mice: C57BL/6
    • Dose: Males: 0, 5, 10, or 20 ppm; 6/concentration.
  • 13 weeks (Inhalation)  (C02799)  Completed 
    • Mice: B6C3F1
    • Dose: M: 0, 2, 4, 10, 20, OR 40 PPM.
  • 8 weeks (Inhalation)  (C10002)  Completed 
    • Mice: B6.129-Trp53<TM1BRD>; Mice: C3B6.129F1-Trp53<TM1BRD>
    • Dose: Males: 0, 7.5, or 15 ppm; 25/concentration.

Genetic Toxicology

  • Drosophila  (084415)  Completed 
    • Citation: Valencia R, Mason JM, Zimmering S. Chemical mutagenesis testing in Drosophila. VI. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ Mol Mutagen. 1989;14(4):238-44. doi: 10.1002/em.2850140405
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Drosophila  (103506)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (247261)  Completed 
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Drosophila  (370104)  Completed 
    • Citation: Valencia R, Mason JM, Zimmering S. Chemical mutagenesis testing in Drosophila. VI. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ Mol Mutagen. 1989;14(4):238-44. doi: 10.1002/em.2850140405
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Drosophila  (907177)  Completed 
    • Citation: Woodruff RC, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(5):677-702. doi: 10.1002/em.2860070507
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • In Vitro Cytogenetics (CA/SCE)  (378046)  Completed 
    • Citation: Galloway SM, Bloom AD, Resnick M, Margolin BH, Nakamura F, Archer P, Zeiger E. Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories. Environ Mutagen. 1985;7(1):1-51. doi: 10.1002/em.2860070102
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (590863)  Completed 
    • Citation: Galloway SM, Bloom AD, Resnick M, Margolin BH, Nakamura F, Archer P, Zeiger E. Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories. Environ Mutagen. 1985;7(1):1-51. doi: 10.1002/em.2860070102
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (000304)  Completed 
    •  Positive 
  • Salmonella  (164784)  Completed 
    •  Positive 
  • Salmonella  (680724)  Completed 
    •  Positive 
  • Salmonella  (761375)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Weakly Positive 
  • Salmonella  (763375)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive 
  • Salmonella  (768375)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive 
  • Salmonella  (830333)  Completed 
    •  Weakly Positive 
  • Salmonella  (A25847)  Completed 
    •  Positive 
  • Salmonella  (A83562)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (T0001A)  Completed 
    • Female Mice
    • Dose: 0, 80, 160, 200 MG/KG/DAY.