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Testing Status of 2-Amino-4-nitrophenol 10005-E

CASRN: 99-57-0

Formula: C6-H6-N2-O3

Synonyms/Common Names

  • C.I. 76530

Short-Term Toxicity

  • 14-Day (Gavage)  (C55958)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55958)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6.3, 200 MG/ML/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55958)  Completed 
    • TR-339 (NIH Number: 88-2595)  (Peer Review Approval 07/14/1987A )
      Toxicology and Carcinogenesis Studies of 2-Amino-4-Nitrophenol (CASRN 99-57-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 125, 250 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (483411)  Completed 
    • Citation: Anderson BE, Zeiger E, Shelby MD, Resnick MA, Gulati DK, Ivett JL, Loveday KS. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen. 1990;16 Suppl 18:55-137. doi: 10.1002/em.2850160505
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A12647)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A57599)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Mouse Lymphoma  (705388)  Completed 
    • Citation: Myhr B, McGregor D, Bowers L, Riach C, Brown AG, Edwards I, McBride D, Martin R, Caspary WJ. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ Mol Mutagen. 1990;16 Suppl 18:138-67. doi: 10.1002/em.2850160506
    • Mice
    •  Positive 
  • Salmonella  (138517)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 
  • Salmonella  (870165)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive