Testing Status of Chlorendic acid 10028-G
CASRN: 115-28-6
Formula: C9-H4-Cl6-O4
Synonyms/Common Names
- 1,4,5,6,7,7-Hexachlorobicyclo(2.2.1)-5-heptene-2,3-dicarboxylic acid
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C55072)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C55072)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 620, 10000, M: 0, 1250, 20000 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C55072)
Completed
- TR-304 (NIH Number: 87-2560)
(Peer Review Approval 08/14/1985A )
Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0, 620, 1250 PPM/50 PER GROUP.
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice No Evidence
- TR-304 (NIH Number: 87-2560)
(Peer Review Approval 08/14/1985A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Intravenous)
(S0074)
Completed
- Citation: Decad GM, Fields MT. Disposition and excretion of chlorendic acid in Fischer 344 rats. J Toxicol Environ Health. 1982 May-Jun;9(5-6):911-20.Pubmed Abstract
- Male Rats [R]
- Dose: (gavage) 3 mg/kg [R]. (intravenous) 3 mg/kg [R].
Genetic Toxicology
- Drosophila
(960855)
Completed
- Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. X. Results of 70 coded chemicals tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(3):208-27. doi: 10.1002/em.2850230310
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(179071)
Completed
- Citation: Anderson BE, Zeiger E, Shelby MD, Resnick MA, Gulati DK, Ivett JL, Loveday KS. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen. 1990;16 Suppl 18:55-137. doi: 10.1002/em.2850160505
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Equivocal
- Mouse Lymphoma
(197818)
Completed
- Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. II: 18 coded chemicals. Environ Mol Mutagen. 1988;11(1):91-118. doi: 10.1002/em.2850110110
- Mice
- Positive
- Salmonella
(995372)
Completed
- Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
- Negative