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Testing Status of Chlorendic acid 10028-G

CASRN: 115-28-6

Formula: C9-H4-Cl6-O4

Synonyms/Common Names

  • 1,4,5,6,7,7-Hexachlorobicyclo(2.2.1)-5-heptene-2,3-dicarboxylic acid

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55072)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55072)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 620, 10000, M: 0, 1250, 20000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C55072)  Completed 
    • TR-304 (NIH Number: 87-2560)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 620, 1250 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice No Evidence 

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous)  (S0074)  Completed 
    • Citation: Decad GM, Fields MT. Disposition and excretion of chlorendic acid in Fischer 344 rats. J Toxicol Environ Health. 1982 May-Jun;9(5-6):911-20.Pubmed Abstract
    • Male Rats [R]
    • Dose: (gavage) 3 mg/kg [R]. (intravenous) 3 mg/kg [R].

Genetic Toxicology

  • Drosophila  (960855)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. X. Results of 70 coded chemicals tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(3):208-27. doi: 10.1002/em.2850230310
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (179071)  Completed 
    • Citation: Anderson BE, Zeiger E, Shelby MD, Resnick MA, Gulati DK, Ivett JL, Loveday KS. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen. 1990;16 Suppl 18:55-137. doi: 10.1002/em.2850160505
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • Mouse Lymphoma  (197818)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. II: 18 coded chemicals. Environ Mol Mutagen. 1988;11(1):91-118. doi: 10.1002/em.2850110110
    • Mice
    •  Positive 
  • Salmonella  (995372)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative