Testing Status of Chlorendic acid 10028-G
CASRN: 115-28-6
Formula: C9-H4-Cl6-O4
Synonyms/Common Names
- 1,4,5,6,7,7-Hexachlorobicyclo(2.2.1)-5-heptene-2,3-dicarboxylic acid
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C55072)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C55072)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 620, 10000, M: 0, 1250, 20000 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C55072)
Completed
- TR-304 (NIH Number: 87-2560)
(Peer Review Approval 08/14/1985A )
Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice No Evidence
- Dose: 0, 620, 1250 PPM/50 PER GROUP.
- TR-304 (NIH Number: 87-2560)
(Peer Review Approval 08/14/1985A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Intravenous)
(S0074)
Completed
- Citation: Decad GM, Fields MT. Disposition and excretion of chlorendic acid in Fischer 344 rats. J Toxicol Environ Health. 1982 May-Jun;9(5-6):911-20.Pubmed Abstract
- Male Rats
- Dose: 3 mg/kg.
Genetic Toxicology
- Drosophila
(960855)
Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(179071)
Completed
- Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Equivocal
- Mouse Lymphoma
(197818)
Completed
- Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
- Mice
- Positive
- Salmonella
(995372)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative