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Testing Status of Hydrochlorothiazide 10029-K

CASRN: 58-93-5

Formula: C7-H8-Cl-N3-O4-S2

Synonyms/Common Names

  • 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55925)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55925)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 250, 4000, M: 0, 3125, 50000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 108 weeks (Dosed-Feed)  (C55925)  Completed 
    • TR-357 (NIH Number: 89-2812)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N
    • Dose: R: 0, 250, 500, 2000 PPM/60 PER GROUP, M: 0, 2500, 5000 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
  • 2 years (Dosed-Feed)  (C55925)  Completed 
    • TR-357 (NIH Number: 89-2812)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Dose: R: 0, 250, 500, 2000 PPM/60 PER GROUP, M: 0, 2500, 5000 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 

Genetic Toxicology

  • Drosophila  (044099)  Completed 
    • Citation: Valencia R, Mason JM, Woodruff RC, Zimmering S. Chemical mutagenesis testing in Drosophila. III. Results of 48 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(3):325-48. doi: 10.1002/em.2860070309
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (949863)  Completed 
    • Citation: Anderson BE, Zeiger E, Shelby MD, Resnick MA, Gulati DK, Ivett JL, Loveday KS. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen. 1990;16 Suppl 18:55-137. doi: 10.1002/em.2850160505
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (573028)  Completed 
    • Citation: Myhr B, McGregor D, Bowers L, Riach C, Brown AG, Edwards I, McBride D, Martin R, Caspary WJ. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ Mol Mutagen. 1990;16 Suppl 18:138-67. doi: 10.1002/em.2850160506
    • Mice
    •  Positive 
  • Salmonella  (715548)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER84084)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 100, 300, 1000 MG/KG/DAY.
    • Rats Maternal Negative 
    • Rats Fetal Negative 
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER84085)  Completed 
    • Female Mice: Swiss
    • Dose: 300, 1000, 3000 MG/KG/DAY.
    • Mice Maternal Negative 
    • Mice Fetal Negative