Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Caffeine 10036-G

CASRN: 58-08-2

Formula: C8-H10-N4-O2

Synonyms/Common Names

  • 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C02733)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Water)  (C02733)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 188, 3000, M: 0, 94, 1500 PPM/12 PER GROUP.

Special Studies

  • C. elegans  (S0873)  Completed 
    • C. elegans [CE]
    • Dose: feed (0, .5, .79, 1.3, 2, 3.2, 5, 7.9, 13, 20, 32, 50) mM 03/23/05. repro (0, .25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25) mM 03/23/05. growth (0, .25, .4, .63, 1, 1.6, 2.5, 3, 6.3, 10, 16, 25) mM 10/09/05.

Genetic Toxicology

  • Salmonella  (075951)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative 
  • Salmonella  (N-9342)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB81078)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .012, .033, .1, .3, 1.0%; 0, .012, .025, .05%; N/A; 0, .05%.
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84044)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .01, .03, .1, .3, 1.0%; 0, .012, .025, .05%; 0, .05%; N/A.
  • 14 weeks Continuous Breeding (Legacy) (Gavage)  (RACB94006)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: TASK 1: 0, 50, 100, 150, OR 200 MG/KG; TASK 2: 0, 12.5, 25, OR 50 MG/KG; TASK 3: 0 OR 50 MG/KG; TASK 4: 0, 12.5, 25, OR 50 MG/KG.
  • 11 GD Conventional Teratology (Intravenous)  (T0009A)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 37.5, 75, 112.5, 150 MG/KG/DAY.
  • 0 to 19 GD Conventional Teratology (Gavage)  (T0009D)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 40, 80 MG/KG/DAY.