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Testing Status of 1,4-Dichlorobenzene (p-dichlorobenzene) 10038-P

CASRN: 106-46-7

Formula: C6-H4-Cl2

Synonyms/Common Names

  • p-Dichlorobenzene

Short-Term Toxicity

  • 14-Day (Gavage)  (C54955A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54955A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 37.5, 600, M: 0, 84.4, 900 MG/KG/60 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C54955A)  Completed 
    • TR-319 (NIH Number: 87-2575)  (Peer Review Approval 03/26/1986A )
      Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 150, 300 MG/KG, FR: 0, 300, 600 MG/KG, M: 0, 300, 600 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 

Special Studies

  • Absorption Distribution Metabolism Excretion (Intraperitoneal Injection; Dosed-Water)  (S0064)  Completed 
    • Male Rats [R]: F344/N
    • Dose: (intraperitoneal injection) 0.9 mmol/kg [R]. (dosed-water) 0.033, 0.33, 3.0 mg/kg [R].

Genetic Toxicology

  • Chromosome Aberrations  (576715)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (983738)  Completed 
    • Citation: Anderson BE, Zeiger E, Shelby MD, Resnick MA, Gulati DK, Ivett JL, Loveday KS. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen. 1990;16 Suppl 18:55-137. doi: 10.1002/em.2850160505
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (447196)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A90787)  Completed 
    • Citation: Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 2000;36(3):163-94
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Mouse Lymphoma  (465704)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. doi: 10.1002/em.2860120111. Erratum in: Environ Mol Mutagen 1988;12(3):345
    • Citation: Myhr B, McGregor D, Bowers L, Riach C, Brown AG, Edwards I, McBride D, Martin R, Caspary WJ. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ Mol Mutagen. 1990;16 Suppl 18:138-67. doi: 10.1002/em.2850160506
    • Mice
    •  Equivocal 
  • Salmonella  (590003)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative