Testing Status of N,N-Dimethylaniline 10039-T

CASRN: 121-69-7

Formula: C8-H11-N

Synonyms/Common Names

• N,N-Dimethylbenzenamine

Short-Term Toxicity

• 14-Day (Gavage)  (C56428)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C56428)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 36.25, 500, M: 0, 62.5, 500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

• 2 years (Gavage)  (C56428)  Completed 
  • TR-360 (NIH Number: 90-2815)  (Peer Review Approval 03/13/1989A )
    Toxicology and Carcinogenesis Studies of N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Some Evidence 
    • Female Rats No Evidence 
    • Male Mice No Evidence 
    • Female Mice Equivocal Evidence 
  • Dose: R: 0, 3, 30, M: 0, 15, 30 MG/KG/50 PER GROUP.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (609568)  Completed 
  • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Mouse Lymphoma  (365373)  Completed 
  • Mice
  •  Positive 
• Salmonella  (840758)  Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 

Organ Systems Toxicity

• 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0092)  Completed 
  • Citation: Screening of Priority Chemicals for Reproductive Hazards
  • Female Mice: Swiss
  • Dose: 365 MG/KG BODY WT..