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Testing Status of Rhodamine 6G 10052-G

 

CASRN: 989-38-8

Formula: C28-H31-N2-O3.Cl

Synonyms/Common Names

  • Basic Red 1
  • C.I. Basic Red 1
  • 2-(6-(Ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl)benzoic acid ethyl ester monohydrochloride (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C56122)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C56122)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .012, .2, M: 0, .05, .8 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56122)  Completed 
    • TR-364 (NIH Number: 89-2819)  (Peer Review Approval 10/04/1988A )
      Toxicology and Carcinogenesis Studies of Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 120, 250, FM: 0, 500, 1000, MM: 0, 1000, 2000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (199566)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (039603)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (666391)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative