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Testing Status of N-Butylbenzenesulfonamide 10057

CASRN: 3622-84-2

Formula: C10-H15-N-O2-S

Synonyms/Common Names

  • Benzenesulfonic acid butyl amide
  • NBBS

Short-Term Toxicity

  • 14 days (Dosed-Feed)  (C10482)  Data in Review 
    • Mice: B6C3F1/N
    • Dose: 0, 1250, 2500, 5000, 10000, or 20000 ppm; 5/sex.
  • 13 weeks (Dosed-Feed)  (C10482B)  Data in Review 
    • Modified One-Generation Study (MOG R# MOG10482B) in Harlan Sprague Dawley Rats
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N

Modified One-Generation

  • GD 6 to PND 28 Dose Range Finding (Dosed-Feed)  (MOG10482)  Completed 
    • Citation: Rider CV, Vallant M, Blystone C, Waidyanatha S, South NL, Xie G, Turner K. Short-term perinatal toxicity study in sprague Dawley rats with the plasticizer and emerging contaminant N-Butylbenzenesulfonamide. Toxicol Lett. 2020 May 11;330:159-166. Epub ahead of print.
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 625, 1250, 2500, 5000 or 10, 000 ppm.
  • Developmental Toxicity (Dosed-Feed)  (MOG10482B)  Data in Review 
    • Developmental Tox Cohort - (Subset C)
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Dosed-Feed)  (MOG10482B)  Data in Review 
    • Definitive study (Dam dose start) - (Subset A)
    • Rats: Harlan Sprague-Dawley
  • Fertility Assessment (Dosed-Feed)  (MOG10482B)  Data in Review 
    • Fertility Cohort
    • Rats: Harlan Sprague-Dawley
  • GD 18 (gestational transfer); PND 4 (lactational transfer) Maternal Transfer (Dosed-Feed)  (MOG10482B)  Data in Review 
    • (Subset B)
    • Rats: Harlan Sprague-Dawley
  • 7 days Neurotoxicology Assessment (Dosed-Feed)  (MOG10482B)  Data in Review 
    • Neurotoxicity Cohort
    • Rats: Harlan Sprague-Dawley
  • 90 days (up to 35 days for mammary analysis) Subchronic (Dosed-Feed)  (MOG10482B)  Data in Review 
    • subchronic with post-weaning mammary gland analysis
    • Rats: Harlan Sprague-Dawley; Rats

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Gavage; Intravenous)  (K10482)  Completed 
    • Citation: Waidyanatha S, Black SR, Patel PR, Rider CV, Watson SL, Snyder RW, Fennell TR. Disposition and metabolism of N-butylbenzenesulfonamide in Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans. Toxicol Lett. 2020 Feb 1;319:225-236. Epub 2019 Nov 21.Pubmed Abstract
    • Male and Female Rats [R]: Harlan Sprague-Dawley; Male and Female Mice [M]: B6C3F1/N
    • Dose: (gavage) 2, 20, or 200 mg/kg [R]. (intravenous) 20 mg/kg [R,M]. (gavage) 20 mg/kg [M].
  • Toxicokinetic Study (Dosed-Feed; Intravenous; Gavage; Dosed-Feed; Intravenous; Gavage)  (K10482B)  Completed 
    • Citation: Waidyanatha S, Gibbs S, South N, Smith JP, Mutlu E, Burback B, Cao Y, Rider CV. Toxicokinetics of the plasticizer, N-butylbenzenesulfonamide, in plasma and brain following oral exposure in rodents; Route, species, and sex comparison. Toxicol. 2020 May 26;7:711-722. doi: Abstract
    • Male Rats [R]: Harlan Sprague-Dawley; Male and Female Rats [R]: Harlan Sprague-Dawley; Male Mice [M]: B6C3F1/N; Male and Female Mice [M]: B6C3F1/N
    • Dose: (dosed-feed) 500, 1000, or 2000 ppm [R,M]. (intravenous) 20 mg/kg [R,M]. (gavage) 20, 60, and 200 mg/kg [R,M].

Genetic Toxicology

  • 13 weeks Micronucleus (Dosed-Feed)  (G10482B)  Completed 
    • Female Mice
    • Mice: B6C3F1/N
  • 17 weeks Micronucleus (Dosed-Feed)  (G10482C)  Completed 
    • Female Rats
    • Rats: Sprague Dawley
  • Salmonella  (G10482)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to PND 42 Developmental Immunotoxicity (Dosed-Feed)  (I10482B)  Report in Preparation 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 500, 1000, or 2000 ppm.
  • 28 days Immunotoxicity (Dosed-Feed)  (I10482)  Report in Preparation 
    • Female Mice: B6C3F1/N
    • Dose: 0, 313, 625, 1250, 2500, or 5000 ppm.