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Testing Status of Isophorone 10070-P

CASRN: 78-59-1

Formula: C9-H14-O

Synonyms/Common Names

  • 3,5,5-Trimethyl-2-cyclohexen-1-one (9CI)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55618)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55618)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 62.5, 1000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55618)  Completed 
    • TR-291 (NIH Number: 86-2547)  (Peer Review Approval 11/02/1984A )
      Toxicology and Carcinogenesis Studies of Isophorone (CASRN 78-59-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 250, 500 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 

Genetic Toxicology

  • Chromosome Aberrations  (783723)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (719644)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. X. Results of 70 coded chemicals tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(3):208-27. doi: 10.1002/em.2850230310
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (624279)  Completed 
    • Citation: Gulati DK, Witt K, Anderson B, Zeiger E, Shelby MD. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Environ Mol Mutagen. 1989;13(2):133-93. doi: 10.1002/em.2850130208
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (490210)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. doi: 10.1002/em.2860120111. Erratum in: Environ Mol Mutagen 1988;12(3):345
    • Mice
    •  Positive 
  • Salmonella  (505090)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative 
  • Sister Chromatid Exchanges  (783723)  Completed 
    • Mice
    • Sister Chromatid  Negative