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Testing Status of 2,4-Diaminophenol dihydrochloride 10106-N

CASRN: 137-09-7

Formula: C6-H8-N2-O.2Cl-H

Synonyms/Common Names

  • Dianol

Short-Term Toxicity

  • 14-Day (Gavage)  (C60026)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C60026)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .012, .200, M: 0, .005, .075 G/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C60026)  Completed 
    • TR-401 (NIH Number: 92-2856)  (Peer Review Approval 03/11/1991A )
      NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CASRN 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 12.5, 25, M: 0, 19, 38 MG/KG/60 PER GROUP.
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 

Genetic Toxicology

  • Drosophila  (431842)  Completed 
    • Citation: Zimmering S, Mason JM, Valencia R, Woodruff RC. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(1):87-100. doi: 10.1002/em.2860070105
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (729737)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (299952)  Completed 
    • Citation: McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I: Results for nine compounds. Environ Mutagen. 1987;9(2):143-60. doi: 10.1002/em.2860090205
    • Mice
    •  Positive 
  • Salmonella  (539410)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive