Testing Status of Polysorbate 80 (glycol) 10122-N
CASRN: 9005-65-6
Formula: C32-H60-O10 (mixture)
Synonyms/Common Names
- Glycol
- Polyoxyethylene sorbitan monooleate
- Tween 80
- (Z)-Sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)-(9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C60286)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C60286)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, .31, 50 %/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C60286)
Completed
- TR-415 (NIH Number: 92-3146)
(Peer Review Approval 07/10/1991A )
Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: 0, 2.5, 5.0%/20 PER GROUP.
- TR-415 (NIH Number: 92-3146)
(Peer Review Approval 07/10/1991A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(862010)
Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Positive
- Salmonella
(405466)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Organ Systems Toxicity
- Conventional Teratology (Gavage)
(TER91009)
Completed
- Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: 0, 500, 5000 MG/KG/DAY.