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Hexachlorocyclopentadiene (77-47-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2020688

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Hexachlorocyclopentadiene (77-47-4).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Hexachlorocyclopentadiene (77-47-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Hexachlorocyclopentadiene (77-47-4).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Hexachlorocyclopentadiene (77-47-4).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. Hexachlorocyclopentadiene (77-47-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-437 Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity (C55607B) of Hexachlorocyclopentadiene (77-47-4) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55607B) of Hexachlorocyclopentadiene (77-47-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Hexachlorocyclopentadiene (77-47-4) in Micronucleus Study A24947 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Hexachlorocyclopentadiene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 725996
Summary Data
Genetic Toxicity Evaluation of Hexachlorocyclopentadiene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A66714
Summary Data

NTP Data Collections