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Testing Status of Hexachlorocyclopentadiene 10125-A

CASRN: 77-47-4

Formula: C5-Cl6

Synonyms/Common Names

  • 1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene (9CI)
  • Perchlorocyclopentadiene

Short-Term Toxicity

  • 13 weeks (Inhalation)  (C55607B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 0.05, 2.0 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55607B)  Completed 
    • TR-437 (NIH Number: 94-3168)  (Peer Review Approval 06/22/1993A )
      Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R:0, .01, .05, .2PPM M:0, .01, .05, .2, .5PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Inhalation)  (S0029)  Completed 
    • Citation: el Dareer SM, Noker PE, Tillery KF, Hill DL. Investigations on the basis for the differential toxicity of hexachlorocyclopentadiene administered to rats by various routes. J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):203-11.Pubmed Abstract
    • Male Rats [R]: F344/N; Male Rats [R]
    • Dose: (gavage) 4.1, 61 mg/kg [R]. (intravenous) 0.59 mg/kg [R]. (inhalation) 1.3 (6h), 1.8 (72h) mg/kg [R].

Genetic Toxicology

  • Drosophila  (386002)  Completed 
    • Citation: Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila: VIII. Reexamination of equivocal results. Environ Mol Mutagen. 1992;19(3):227-34. doi: 10.1002/em.2850190307
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (842404)  Completed 
    • Citation: Zimmering S, Mason JM, Valencia R, Woodruff RC. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(1):87-100. doi: 10.1002/em.2860070105
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (353427)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A24947)  Completed 
    • Citation: Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 2000;36(3):163-94
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (725996)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 
  • Salmonella  (A66714)  Completed 
    •  Negative