Testing Status of Hexachlorocyclopentadiene 10125-A
CASRN: 77-47-4
Formula: C5-Cl6
Synonyms/Common Names
- 1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene (9CI)
- Perchlorocyclopentadiene
Short-Term Toxicity
- 13 weeks (Inhalation)
(C55607B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 0.05, 2.0 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C55607B)
Completed
- TR-437 (NIH Number: 94-3168)
(Peer Review Approval 06/22/1993A )
Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R:0, .01, .05, .2PPM M:0, .01, .05, .2, .5PPM/50 PER GROUP.
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- TR-437 (NIH Number: 94-3168)
(Peer Review Approval 06/22/1993A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Intravenous; Inhalation)
(S0029)
Completed
- Citation: el Dareer SM, Noker PE, Tillery KF, Hill DL. Investigations on the basis for the differential toxicity of hexachlorocyclopentadiene administered to rats by various routes. J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):203-11.Pubmed Abstract
- Male Rats [R]: F344/N; Male Rats [R]
- Dose: (gavage) 4.1, 61 mg/kg [R]. (intravenous) 0.59 mg/kg [R]. (inhalation) 1.3 (6h), 1.8 (72h) mg/kg [R].
Genetic Toxicology
- Drosophila
(386002)
Completed
- Citation: Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila: VIII. Reexamination of equivocal results. Environ Mol Mutagen. 1992;19(3):227-34. doi: 10.1002/em.2850190307
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Drosophila
(842404)
Completed
- Citation: Zimmering S, Mason JM, Valencia R, Woodruff RC. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(1):87-100. doi: 10.1002/em.2860070105
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(353427)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(A24947)
Completed
- Citation: Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 2000;36(3):163-94
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(725996)
Completed
- Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
- Negative
- Salmonella
(A66714)
Completed
- Negative