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Testing Status of Hexachloroethane 10126-E

CASRN: 67-72-1

Formula: C2-Cl6

Synonyms/Common Names

  • Carbon hexachloride

Short-Term Toxicity

  • 14-Day (Gavage)  (C04604A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 14-Day (Gavage)  (C04604B)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C04604A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 178, 1780, M: 0, 316, 3160 MG/KG/5 PER GROUP.
  • 13-Week (Gavage)  (C04604B)  Completed 
    • Rats: F344/N
    • Dose: 0, .047, .750 G/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04604A)  Completed 
    • TR-068 (NIH Number: 78-1318)  (Peer Review Approval 01/18/1978A )
      Bioassay of Hexachloroethane for Possible Carcinogenicity (CASRN 67-72-1)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 212, 423 M:0, 590, 1179 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
  • 2 years (Gavage)  (C04604B)  Completed 
    • TR-361 (NIH Number: 89-2816)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage Studies)
    • Rats: F344/N
    • Dose: MR: 0, 10, 20, FR: 0, 80, 160 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats No Evidence 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (415312)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (188925)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 
  • Salmonella  (248997)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative