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Testing Status of Hexachloroethane 10126-E

 

CASRN: 67-72-1

Formula: C2-Cl6

Synonyms/Common Names

  • Carbon hexachloride

Short-Term Toxicity

  • 14-Day (Gavage)  (C04604A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 14-Day (Gavage)  (C04604B)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C04604A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 178, 1780, M: 0, 316, 3160 MG/KG/5 PER GROUP.
  • 13-Week (Gavage)  (C04604B)  Completed 
    • Rats: F344/N
    • Dose: 0, .047, .750 G/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04604A)  Completed 
    • TR-068 (NIH Number: 78-1318)  (Peer Review Approval 01/18/1978A )
      Bioassay of Hexachloroethane for Possible Carcinogenicity (CASRN 67-72-1)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 212, 423 M:0, 590, 1179 MG/KG/50 PER GROUP.
  • 2 years (Gavage)  (C04604B)  Completed 
    • TR-361 (NIH Number: 89-2816)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats No Evidence 
    • Dose: MR: 0, 10, 20, FR: 0, 80, 160 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (415312)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (188925)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (248997)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative