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Testing Status of Nitrobenzene 10141-A

 

CASRN: 98-95-3

Formula: C6-H5-N-O2

Synonyms/Common Names

  • Oil of mirbane

Short-Term Toxicity

  • 14-Day (Topical Application)  (C60082B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Topical Application)  (C60082B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 0.05, 0.08 G/KG/10 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (694968)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (193955)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (542172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM95003)  Completed 
    • Citation: Burns LA, Bradley SG, White KL Jr, McCay JA, Fuchs BA, Stern M, Brown RD, Musgrove DL, Holsapple MP, Luster MI, Munson, AE. Immunotoxicity of nitrobenzene in female B6C3F1 mice. Drug Chem Toxicol. 1994;17(3):271-315.
    • Female Mice: B6C3F1
    • Dose: 0, 30, 100, AND 300 MG/KG.