Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Styrene 10166-K

CASRN: 100-42-5

Formula: C8-H8

Synonyms/Common Names

  • Ethenylbenzene (9CI)
  • Phenylethylene
  • Vinylbenzene

Short-Term Toxicity

  • 14-Day (Gavage)  (C02200A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 2 weeks (Inhalation)  (C02200B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 30, 100, 300, 1000, 0R 2000 PPM (5/S/S).
  • 13-Week (Gavage)  (C02200A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 681, 3160, M: 0, 147, 681 MG/KG/10 PER GROUP.
  • 13 weeks (Inhalation)  (C02200B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 125, 250, 500, 1000, OR 1500 PPM M: 0, 62.5, 125, 250, OR 500 PPM.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C02200A)  Completed 
    • TR-185 (NIH Number: 79-1741)  (Peer Review Approval 10/25/1978A )
      Bioassay of Styrene for Possible Carcinogenicity (CASRN 100-42-5)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 500, 1000, 2000, M: 0, 150, 300 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Negative 

Special Studies

  • Mechanisms (Inhalation)  (S0333)  Completed 
    • Citation: Mahler JF, Price HC Jr, O'Connor RW, Wilson RF, Eldridge SR, Moorman MP, Morgan DL. Characterization of hepatocellular resistance and susceptibility to styrene toxicity in B6C3F1 mice. Toxicol Sci. 1999 Mar;48(1):123-33. Pubmed Abstract
    • Citation: Morgan DL, Mahler JF, Dill JA, Price HC Jr, O'Connor RW, Adkins B Jr. Styrene inhalation toxicity studies in mice. II. Sex differences in susceptibility of B6C3F1 mice. Fundam Appl Toxicol. 1993 Oct;21(3):317-25. Pubmed Abstract
    • Citation: Morgan DL, Mahler JF, Dill JA, Price HC Jr, O'Connor RW, Adkins B Jr. Styrene inhalation toxicity studies in mice. III. Strain differences in susceptibility. Fundam Appl Toxicol. 1993 Oct;21(3):326-33.Pubmed Abstract
    • Male and Female Mice [M]: B6C3F1; Male and Female Mice [M]: C57BL/6; Male and Female Mice [M]: Swiss; Male and Female Mice [M]
    • Dose: (inhalation) 125, 250 or 500 ppm [M].

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (987609)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (173117)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen. 1988;11 Suppl 12:1-157
    •  Negative 
  • Salmonella  (N-9246)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248