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Testing Status of Trichloroethylene 10175-P

CASRN: 79-01-6

Formula: C2-H-Cl3

Synonyms/Common Names

  • Trichloroethene (9Ci)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04546A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 4 weeks (Dosed-Feed)  (C04546G)  Completed 
    • Rats: F344/N
  • 4 weeks (Gavage)  (C04546H)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C04546A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 562, 5620, M: 0, 1000, 10000 MG/KG/5 PER GROUP.
  • 13-Week (Gavage)  (C04546B)  Completed 
    • Rats: ACI; Rats: August
    • Dose: MR: 0, 125, 2000, FR: 0, 62.5, 1000 MG/KG/10 PER GROUP.
  • 13-Week (Gavage)  (C04546C)  Completed 
    • Rats: Marshall; Rats: Osborne Mendel
    • Dose: RB:MR: 0, 268, 1834, FR: 0, 134, 918 MG/KG/10 PER GROUP.
  • 13-Week (Gavage)  (C04546E)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 125, 2000, FR: 0, 62.5, 1000, M: 0, 375, 6000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04546A)  Completed 
    • TR-002 (NIH Number: 76-802)  (Peer Review Approval NA)
      Carcinogenesis Bioassay of Trichloroethylene (CASRN 79-01-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 549, 1097 MM: 0, 1169, 2339 FM: 0, 869, 1739 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
  • 107 weeks (Gavage)  (C04546B)  Completed 
    • TR-273 (NIH Number: 88-2529)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: ACI
    • Dose: 0, 500, 1000 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
  • 2 years (Gavage)  (C04546B)  Completed 
    • TR-273 (NIH Number: 88-2529)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: August
    • Dose: 0, 500, 1000 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
  • 2 years (Gavage)  (C04546C)  Completed 
    • TR-273 (NIH Number: 88-2529)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: Marshall; Rats: Osborne Mendel
    • Dose: 0, 500, 1000 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
  • 121 weeks (Gavage)  (C04546E)  Completed 
    • TR-243 (NIH Number: 90-1799)  (Peer Review Approval 09/22/1982A )
      Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 500, 1000, M: 0, 1000 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 

Special Studies

  • Absorption Distribution Metabolism Excretion (Intraperitoneal Injection; Dosed-Water)  (S0061)  Completed 
    • Male Rats [R]: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (316661)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (389288)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(1):51-63. doi: 10.1002/em.2850230109
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (365766)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (679194)  Completed 
    • Citation: Shelby MD, Erexson GL, Hook GJ, Tice RR. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen. 1993;21(2):160-79
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (114328)  Completed 
    • Mice
    •  Positive 
  • Mouse Lymphoma  (623351)  Completed 
    • Citation: Myhr BC, Caspary WJ. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environ Mol Mutagen. 1991;18(1):51-83. doi: 10.1002/em.2850180109
    • Mice
    •  Positive 
  • Salmonella  (536227)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative 
  • Salmonella  (574937)  Completed 
    •  Negative 
  • Sister Chromatid Exchanges  (316661)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • greater than 20 days minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84112)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 0, .6, 1.2, 2.4, 3.61, 4.82%; 0, .15, .3, .6%; 0, .6%; 0, .15, .3, .6%.
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84113)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .6, 1.2, 2.4, 3.61, 4, 82%; 0, .15, .3, .6%; N/A; 0, .6%.
  • 14 days Immunotoxicity (Gavage)  (IMM20006)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 50, 75, 100, 150, 200, 250, 300, 350, 400, 500, OR 800 MG/KG.
  • 14 days Immunotoxicity (Gavage)  (IMM20008)  Completed 
    • Male Mice: Swiss CD-1
    • Dose: 0, 125, 250, OR 500 MG/KG.
  • 56 days Immunotoxicity (Gavage)  (IMM96007)  Completed 
    • Female Rats: Brown-Norway
    • Dose: 0 OR 500 MG/KG/DAY.
  • 56 days Immunotoxicity (Gavage)  (IMM97002)  Completed 
    • Female Rats: Brown-Norway
    • Dose: 0, 100, 200, OR 400 MG/KG/DAY.
  • 14 days Immunotoxicity (Gavage)  (IMM98010)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 50, 75, 100, 150, 200, 250, 300, 350, 400, 500, OR 800 MG/KG.