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Testing Status of Trichloroethylene 10175-P

 

CASRN: 79-01-6

Formula: C2-H-Cl3

Synonyms/Common Names

  • Trichloroethene (9Ci)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04546A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 4 weeks (Dosed-Feed)  (C04546G)  Completed 
    • Rats: F344/N
  • 4 weeks (Gavage)  (C04546H)  Completed 
    • Rats: F344/N
  • 13-Week (Gavage)  (C04546A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 562, 5620, M: 0, 1000, 10000 MG/KG/5 PER GROUP.
  • 13-Week (Gavage)  (C04546B)  Completed 
    • Rats: ACI; Rats: August
    • Dose: MR: 0, 125, 2000, FR: 0, 62.5, 1000 MG/KG/10 PER GROUP.
  • 13-Week (Gavage)  (C04546C)  Completed 
    • Rats: Marshall; Rats: Osborne Mendel
    • Dose: RB:MR: 0, 268, 1834, FR: 0, 134, 918 MG/KG/10 PER GROUP.
  • 13-Week (Gavage)  (C04546E)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 125, 2000, FR: 0, 62.5, 1000, M: 0, 375, 6000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04546A)  Completed 
    • TR-002 (NIH Number: 76-802)  (Peer Review Approval NA)
      Carcinogenesis Bioassay of Trichloroethylene (CASRN 79-01-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 549, 1097 MM: 0, 1169, 2339 FM: 0, 869, 1739 MG/KG/50 PER GROUP.
  • 107 weeks (Gavage)  (C04546B)  Completed 
    • TR-273 (NIH Number: 88-2529)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: ACI
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
    • Dose: 0, 500, 1000 MG/KG/50 PER GROUP.
  • 2 years (Gavage)  (C04546B)  Completed 
    • TR-273 (NIH Number: 88-2529)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: August
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
    • Dose: 0, 500, 1000 MG/KG/50 PER GROUP.
  • 2 years (Gavage)  (C04546C)  Completed 
    • TR-273 (NIH Number: 88-2529)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
    • Rats: Marshall; Rats: Osborne Mendel
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
    • Dose: 0, 500, 1000 MG/KG/50 PER GROUP.
  • 121 weeks (Gavage)  (C04546E)  Completed 
    • TR-243 (NIH Number: 90-1799)  (Peer Review Approval 09/22/1982A )
      Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 500, 1000, M: 0, 1000 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Intraperitoneal Injection; Dosed-Water)  (S0061)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (316661)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (389288)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (365766)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (679194)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (114328)  Completed 
    • Mice
    •  Positive 
  • Mouse Lymphoma  (623351)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Salmonella  (536227)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (574937)  Completed 
    •  Negative 
  • Sister Chromatid Exchanges  (316661)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • greater than 20 days minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84112)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 0, .6, 1.2, 2.4, 3.61, 4.82%; 0, .15, .3, .6%; 0, .6%; 0, .15, .3, .6%.
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84113)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, .6, 1.2, 2.4, 3.61, 4, 82%; 0, .15, .3, .6%; N/A; 0, .6%.
  • 14 days Immunotoxicity (Gavage)  (IMM20006)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 50, 75, 100, 150, 200, 250, 300, 350, 400, 500, OR 800 MG/KG.
  • 14 days Immunotoxicity (Gavage)  (IMM20008)  Completed 
    • Male Mice: Swiss CD-1
    • Dose: 0, 125, 250, OR 500 MG/KG.
  • 56 days Immunotoxicity (Gavage)  (IMM96007)  Completed 
    • Female Rats: Brown-Norway
    • Dose: 0 OR 500 MG/KG/DAY.
  • 56 days Immunotoxicity (Gavage)  (IMM97002)  Completed 
    • Female Rats: Brown-Norway
    • Dose: 0, 100, 200, OR 400 MG/KG/DAY.
  • 14 days Immunotoxicity (Gavage)  (IMM98010)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 50, 75, 100, 150, 200, 250, 300, 350, 400, 500, OR 800 MG/KG.