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Testing Status of Tetrachloroethylene 10176-T

CASRN: 127-18-4

Formula: C2-Cl4

Synonyms/Common Names

  • Perchloroethylene
  • Tetrachloroethene (9CI)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04580A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04580A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 316, 3160, M: 0, 562, 5620 MG/KG/10 PER GROUP.
  • 13-Week (Inhalation)  (C04580F)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 100, 1600 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04580A)  Completed 
    • TR-013 (NIH Number: 77-813)  (Peer Review Approval 09/26/1977A )
      Bioassay of Tetrachloroethylene for Possible Carcinogenicity (CASRN 127-18-4)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 600, 1200 (AVG), MM: 0, 500, 1000 (AVG), FM: 0, 350, 700 (AVG) MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
      • Male Mice Positive 
      • Female Mice Positive 
  • 2 years (Inhalation)  (C04580F)  Completed 
    • TR-311 (NIH Number: 86-2567)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 200, 400, M: 0, 100, 200 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 

Genetic Toxicology

  • Chromosome Aberrations  (053083)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (602369)  Completed 
    • Citation: Valencia R, Mason JM, Woodruff RC, Zimmering S. Chemical mutagenesis testing in Drosophila. III. Results of 48 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(3):325-48. doi: 10.1002/em.2860070309
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (214014)  Completed 
    • Citation: Anderson BE, Zeiger E, Shelby MD, Resnick MA, Gulati DK, Ivett JL, Loveday KS. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ Mol Mutagen. 1990;16 Suppl 18:55-137. doi: 10.1002/em.2850160505
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (245795)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (616544)  Completed 
    • Citation: Myhr B, McGregor D, Bowers L, Riach C, Brown AG, Edwards I, McBride D, Martin R, Caspary WJ. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ Mol Mutagen. 1990;16 Suppl 18:138-67. doi: 10.1002/em.2850160506
    • Mice
    •  Equivocal 
  • Mouse Lymphoma  (642016)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. doi: 10.1002/em.2860120111. Erratum in: Environ Mol Mutagen 1988;12(3):345
    • Citation: Myhr B, McGregor D, Bowers L, Riach C, Brown AG, Edwards I, McBride D, Martin R, Caspary WJ. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ Mol Mutagen. 1990;16 Suppl 18:138-67. doi: 10.1002/em.2850160506
    • Mice
    •  Equivocal 
  • Mouse Lymphoma  (776521)  Completed 
    • Citation: Myhr B, McGregor D, Bowers L, Riach C, Brown AG, Edwards I, McBride D, Martin R, Caspary WJ. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ Mol Mutagen. 1990;16 Suppl 18:138-67. doi: 10.1002/em.2850160506
    • Mice
    •  Equivocal 
  • Salmonella  (269792)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 

Organ Systems Toxicity

  • 5 days/week for 3 weeks before breeding and/or 1 to 6 GD and 7 to 21 GD Conventional Teratology (Inhalation)  (T0097A)  Completed 
    • Citation: Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene, Carbon Disulfide
    • Female Rabbits: New Zealand White
    • Dose: 500 ppm 7 hr/day.
  • 5 days/wk for 3 wks before breeding and/or 1 to 6 GD and 7 to 21 GD Conventional Teratology (Inhalation)  (T0097B)  Completed 
    • Citation: Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene, Carbon Disulfide
    • Female Rats: Sprague Dawley
    • Dose: 500 ppm 7 hr/day.