Testing Status of Estragole 10259-V

CASRN: 140-67-0

Formula: C10-H12-O

Synonyms/Common Names

• 4-Allylanisole
• 4-Allyl-1-methoxybenzene
• Chavicol methyl ether
• Estragole
• 1-Methoxy-4-(2-propenyl)benzene
• Methyl chavicol
• p-Methoxyallylbenzene

Short-Term Toxicity

• 4 days (Gavage)  (C10259)  Completed 
  • Liver Targeted Testing study of Toxcast Chemicals
  • Rats: Harlan Sprague-Dawley
  • Dose: Male rats: 0, 600 mg/kg/day.
• 13 weeks (Gavage)  (C60946)  Completed 
  • TOX-82 (NIH Number: 11-5966)
    Toxicity Studies of Estragole (CASRN 140-67-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 37.5, 75, 150, 300, OR 600 MG/KG; 10/SEX/DOSE.

Special Studies

• Absorption Distribution Metabolism Excretion (Gavage; in-vitro)  (S0798)  Completed 
  • Citation: Iyer LV, Ho MN, Shinn WM, Bradford WW, Tanga MJ, Nath SS, Green CE. Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. Toxicol Sci. 2003 May;73(1):36-43. Epub 2003 Mar 25.Pubmed Abstract
  • Rats [R]: F344/N; Mice [M]: B6C3F1; Human (Cell Lines) [HU]

Genetic Toxicology

• Micronucleus  (A82089)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (802383)  Completed 
  • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
  •  Negative 

Toxicogenomics

• 4 days Microarray Analysis (Gavage)  (T10259)  Completed 
  • Liver Targeted Testing study of Toxcast Chemicals
  • Rats: Harlan Sprague-Dawley
  • Dose: not provided; 6 rats.