Testing Status of Triamterene 10276-Y

CASRN: 396-01-0

Formula: C12-H11-N7

Synonyms/Common Names

• 6-Phenyl-2,4,7-pteridinetriamine (9CI)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C56042A)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C56042A)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 150, 2400, M: 0, 100, 1600 PPM/10 PER GROUP.

Long-Term Carcinogenicity

• 2 years (Dosed-Feed)  (C56042B)  Completed 
  • TR-420 (NIH Number: 94-3151)  (Peer Review Approval 11/21/1991A )
    Toxicology and Carcinogenesis Studies of Triamterene (CASRN 396-01-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 150, 300, 600, M: 0, 100, 200, 400 PPM RESTART MICE: 0, 400 PPM/50 PER GROUP.
  • Carcinogenesis Results
    • Male Rats Equivocal Evidence 
    • Female Rats No Evidence 
    • Male Mice Some Evidence 
    • Female Mice Some Evidence 

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (695685)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Negative 
• Salmonella  (190695)  Completed 
  • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
  •  Negative 
• Salmonella  (303754)  Completed 
  • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
  •  Negative