Testing Status of Triamterene 10276-Y
CASRN: 396-01-0
Formula: C12-H11-N7
Synonyms/Common Names
- 6-Phenyl-2,4,7-pteridinetriamine (9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C56042A)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C56042A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 150, 2400, M: 0, 100, 1600 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C56042B)
Completed
- TR-420 (NIH Number: 94-3151)
(Peer Review Approval 11/21/1991A )
Toxicology and Carcinogenesis Studies of Triamterene in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats No Evidence
- Male Mice Some Evidence
- Female Mice Some Evidence
- Dose: R: 0, 150, 300, 600, M: 0, 100, 200, 400 PPM RESTART MICE: 0, 400 PPM/50 PER GROUP.
- TR-420 (NIH Number: 94-3151)
(Peer Review Approval 11/21/1991A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(695685)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Salmonella
(190695)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(303754)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative