Testing Status of Urethane 10359-A

CASRN: 51-79-6

Formula: C3-H7-N-O2

Synonyms/Common Names

Carbamic acid, ethyl ester (9CI)
Ethyl carbamate

Short-Term Toxicity

13 weeks (Dosed-Water) (C00602B) Completed
- TOX-52 (NIH Number: 96-3937) (Tox Peer Review 06/00/1995A )
  Toxicity Studies of Urethane in Drinking Water and Urethane in 5% Ethanol Administered to F344/N Rats and B6C3F1 Mice
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: (DEIONIZED WATER VEHICLE) 0.011, 0.033, 0.11, 0.33, OR 1.0 G/100 ML.

Long-Term Carcinogenicity

2 years (Dosed-Water) (C00602D) Completed
- TR-510 (NIH Number: 04-4444) (Peer Review Approval 09/05/2002A )
  Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CASRNs 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
- Mice: B6C3F1 (NCTR)
- Carcinogenesis Results
  - Male Mice Clear Evidence
  - Female Mice Clear Evidence
- Dose: 0, 10, 30, OR 90 PPM.

Special Studies

Absorption Distribution Metabolism Excretion (Intravenous) (S0768) Completed
- Male Rats: F344/N; Mice: B6C3F1
- Dose: 4.75, 119 mg/kg [R,M].
Absorption Distribution Metabolism Excretion (Intravenous; Gavage; Intravenous) (S0769) Completed
- Citation: Nomeir AA, Ioannou YM, Sanders JM, Matthews HB. Comparative metabolism and disposition of ethyl carbamate (urethane) in male Fischer 344 rats and male B6C3F1 mice. Toxicol Appl Pharmacol. 1989 Feb;97(2):203-15.Pubmed Abstract
- Male Rats: F344/N; Male Rats: Fischer 344; Male Mice: B6C3F1
- Dose: 0.475, 4.75, 15, 47.5, 119, 235, 475 mg/kg. 4.75, 47.5, 119, 475 mg/kg. 47.5, 475 mg/kg.

Genetic Toxicology

Drosophila (709383) Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Positive
In Vitro Cytogenetics (CA/SCE) (817366) Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
Micronucleus (A06541) Completed
- Mice: B6C3F1
- Male Positive
Micronucleus (A36432) Completed
- Mice: B6C3F1
- Male Positive
- Female Positive
Micronucleus (A44972) Completed
- Mice: B6C3F1
- Male Negative
Micronucleus (A86637) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Positive
- Female Positive
Salmonella (113016) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Equivocal
Salmonella (588195) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Positive

Organ Systems Toxicity

Dominant Lethal (Male) (DLM030) Completed
- Citation: Russell, L.B., Hunsicker, P.R., Oakberg, E.F., Cummings, C.C. and Schmoyer, R.L. Test for urethane induction of germ-cell mutations and germ cell killing in the mouse. Mutation Res. 188:335-342 (1987).
- Male Mice: 101 X C3H
- Mice Male Negative
14 days Immunotoxicity (Subcutaneous Injection) (IMM83002) Completed
- Female Mice: B6C3F1
- Dose: 0, 70, 140, OR 280 MG/KG ETHYL CARBAMATE, 280 MG/KG METHYL CARBAMATE.
Morphological Specific Locus (MSLM46) Completed
- Citation: Russell, L.B., Hunsicker, P.R., Oakberg, E.F., Cummings, C.C. and Schmoyer, R.L. Test for urethane induction of germ-cell mutations and germ cell killing in the mouse. Mutation Res. 188:335-342 (1987).
- Male Mice: 101 X C3H
- Mice Male Negative