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Testing Status of Aniline 10379-R

CASRN: 62-53-3

Formula: C6-H7-N

Synonyms/Common Names

  • Benzenamine

Genetic Toxicology

  • Drosophila  (150001)  Completed 
    • Citation: Yoon JS, Mason JM, Valencia R, Woodruff RC, Zimmering S. Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(3):349-67. doi: 10.1002/em.2860070310
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (997531)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Micronucleus  (A17175)  Completed 
    • Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutat Res. 2002 Nov 26;521(1-2):201-8. doi: 10.1016/s1383-5718(02)00241-3
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A29061)  Completed 
    • Citation: Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 2000;36(3):163-94
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Mouse Lymphoma  (256722)  Completed 
    • Mice
    •  Positive 
  • Mouse Lymphoma  (423002)  Completed 
    • Citation: McGregor DB, Brown AG, Howgate S, McBride D, Riach C, Caspary WJ. Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals. Environ Mol Mutagen. 1991;17(3):196-219. doi: 10.1002/em.2850170309
    • Mice
    •  Positive 
  • Salmonella  (712474)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0013)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 560 MG/KG BODY WT.