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Testing Status of Iodoform 10398-D

 

CASRN: 75-47-8

Formula: C-H-I3

Synonyms/Common Names

  • Triiodomethane (9CI)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04568)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04568)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 56, 562, M: 0, 18, 178 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04568)  Completed 
    • TR-110 (NIH Number: 78-1365)  (Peer Review Approval 04/26/1978A )
      Bioassay of Iodoform for Possible Carcinogenicity (CASRN 75-47-8)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0, 71, 142 (AVG), FR: 0, 27, 55 (AVG), M: 0, 47, 93 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (123235)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (367919)  Completed 
    •  Positive 
  • Salmonella  (837276)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive