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Testing Status of Azinphosmethyl 10424-L

CASRN: 86-50-0

Formula: C10-H12-N3-O3-P-S2

Synonyms/Common Names

  • Phosphorodithioic acid, O,O-dimethyl S-((4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl) ester

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00066)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00066)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R&FM: 0, 62.5, 1000, MM: 0, 7.8, 125 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00066)  Completed 
    • TR-069 (NIH Number: 78-1319)  (Peer Review Approval 06/29/1978A )
      Bioassay of Azinphosmethyl for Possible Carcinogenicity (CASRN 86-50-0)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: FR&FM: 0, 62.5, 125, MR: 0, 78, 156 (AVG), MM: 0, 31.3, 62.5 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (930409)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (256211)  Completed 
    •  Positive 
  • Salmonella  (909450)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Weakly Positive