Testing Status of 1-Nitronaphthalene 10425-R
CASRN: 86-57-7
Formula: C10-H7-N-O2
Synonyms/Common Names
- alpha-Nitronaphthalene
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01956)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C01956)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 0.05, 0.15 %/5 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01956)
Completed
- TR-064 (NIH Number: 78-1314)
(Peer Review Approval 01/18/1978A )
Bioassay of 1-Nitronaphthalene for Possible Carcinogenicity (CASRN 86-57-7) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, .06, .18 (AVG), M: 0, .6, .12 (AVG) %/50 PER GROUP.
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- TR-064 (NIH Number: 78-1314)
(Peer Review Approval 01/18/1978A )
Genetic Toxicology
- Drosophila
(062555)
Completed
- Citation: Valencia R, Mason JM, Woodruff RC, Zimmering S. Chemical mutagenesis testing in Drosophila. III. Results of 48 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(3):325-48. doi: 10.1002/em.2860070309
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(153730)
Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Weakly Positive
- Salmonella
(983172)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
- Positive
- Salmonella
(CV-271)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248