Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of o-Cresol 10455-P

CASRN: 95-48-7

Formula: C7-H8-O

Synonyms/Common Names

  • 2-Methylphenol

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C62168)  Completed 
    • TOX-09 (NIH Number: 92-3128)  (Peer Review Approval 11/20/1990A )
      Toxicity Studies of Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C62168)  Completed 
    • TOX-09 (NIH Number: 92-3128)
      Toxicity Studies of Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0, .03, .1, .3, 1.0, 3.0%.

Genetic Toxicology

  • Micronucleus  (A02909)  Completed 
    • Citation: Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 2000;36(3):163-94
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (478797)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB90001)  Completed 
    • Mice: Swiss
    • Dose: 0, 0.25, 0.5, 1.0, 2.0, 3.0%; 0, 0.05, 0.2, 0.5%; N/A; 0, 0.5%; .
  • Varies Immunotoxicity (Topical Application)  (IMM20710)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 0.5, 1, 2.5, 5, OR 10%.