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Testing Status of 5-Chloro-o-toluidine 10462-K

CASRN: 95-79-4

Formula: C7-H8-Cl-N

Synonyms/Common Names

  • 5-Chloro-2-methylbenzenamine

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02051)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02051)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 315, 6800, M: 0, 255, 5500 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02051)  Completed 
    • TR-187 (NIH Number: 79-1743)  (Peer Review Approval 10/25/1978A )
      Bioassay of 5-Chloro-o-toluidine for Possible Carcinogenicity (CASRN 95-79-4)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 2500, 5000, M: 0, 2000, 4000 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (428912)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (250705)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. doi: 10.1002/em.2860120111. Erratum in: Environ Mol Mutagen 1988;12(3):345
    • Mice
    •  Negative 
  • Salmonella  (092475)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 
  • Salmonella  (729677)  Completed 
    •  Negative 
  • Salmonella  (763573)  Completed 
    •  Negative