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Testing Status of Caprolactam 10505-F

CASRN: 105-60-2

Formula: C6-H11-N-O

Synonyms/Common Names

  • Hexahydro-2H-azepin-2-one (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50646)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50646)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 625, 750, M: 0, 5000, 30000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50646)  Completed 
    • TR-214 (NIH Number: 81-1770)  (Peer Review Approval 06/27/1980A )
      Carcinogenesis Bioassay of Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 3750, 7500, M: 0, 7500, 15000 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • Chromosome Aberrations  (201538)  Completed 
    • Citation: McFee AF, Lowe KW. Caprolactam and benzoin: tests for induction of chromosome aberrations and SCEs in mouse bone marrow. Mutat Res. 1989 Nov;224(3):347-50. doi: 10.1016/0165-1218(89)90177-8
    • Mice
    •  Negative (Nonstandard Protocol) 
  • Drosophila  (650562)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(1):51-63. doi: 10.1002/em.2850230109
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (641268)  Completed 
    • Citation: Gulati DK, Witt K, Anderson B, Zeiger E, Shelby MD. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Environ Mol Mutagen. 1989;13(2):133-93. doi: 10.1002/em.2850130208
    • Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (222213)  Completed 
    • Citation: Shelby MD, Erexson GL, Hook GJ, Tice RR. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen. 1993;21(2):160-79
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (127633)  Completed 
    • Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
    • Mice
    •  Negative 
  • Salmonella  (572383)  Completed 
    • Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
    •  Negative 
  • Sister Chromatid Exchanges  (201538)  Completed 
    • Citation: McFee AF, Lowe KW. Caprolactam and benzoin: tests for induction of chromosome aberrations and SCEs in mouse bone marrow. Mutat Res. 1989 Nov;224(3):347-50. doi: 10.1016/0165-1218(89)90177-8
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)