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Testing Status of Chlorobenzene 10528-H

CASRN: 108-90-7

Formula: C6-H5-Cl

Synonyms/Common Names

  • Benzene, chloro-
  • Monochlorbenzene

Short-Term Toxicity

  • 14-Day (Gavage)  (C54886)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54886)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 60, 750 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54886)  Completed 
    • TR-261 (NIH Number: 86-2517)  (Peer Review Approval 02/28/1983A )
      Toxicology and Carcinogenesis Studies of Chlorobenzene (CASRN 108-90-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&FM: 0, 60, 120, MM: 0, 30, 60 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Special Studies

  • Absorption Distribution Metabolism Excretion (Intraperitoneal Injection; Dosed-Water)  (S0300)  Completed 
    • Male Rats [R]: F344/N
  • Metabolism (Gavage)  (S0299)  Completed 
    • Male Rats [R]: F344/N
    • Dose: (gavage) 65 mg/kg repeated dose for 11 days [R].
  • Toxicokinetic Study (Topical Application)  (S0247)  Completed 
    • Male Rats [R]: F344/N
    • Dose: (topical application) 0.65, 6.5, 65 mg/kg [R].

Genetic Toxicology

  • Chromosome Aberrations  (569047)  Completed 
    • Citation: Shelby MD, Witt KL. Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests. Environ Mol Mutagen. 1995;25(4):302-13. doi: 10.1002/em.2850250407
    • Mice
    •  Positive (Nonstandard Protocol) 
  • Drosophila  (469545)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. X. Results of 70 coded chemicals tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(3):208-27. doi: 10.1002/em.2850230310
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (930766)  Completed 
    • Citation: Loveday KS, Lugo MH, Resnick MA, Anderson BE, Zeiger E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals. Environ Mol Mutagen. 1989;13(1):60-94. doi: 10.1002/em.2850130108. Erratum in: Environ Mol Mutagen 1989;13(2):195
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (423738)  Completed 
    • Citation: Shelby MD, Erexson GL, Hook GJ, Tice RR. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen. 1993;21(2):160-79
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (103069)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. doi: 10.1002/em.2860120111. Erratum in: Environ Mol Mutagen 1988;12(3):345
    • Mice
    •  Positive 
  • Salmonella  (159799)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 
  • Salmonella  (559799)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 
  • Sister Chromatid Exchanges  (569047)  Completed 
    • Citation: Shelby MD, Witt KL. Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests. Environ Mol Mutagen. 1995;25(4):302-13. doi: 10.1002/em.2850250407
    • Mice
    • Sister Chromatid  Negative