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Testing Status of Aldicarb 10539-V

CASRN: 116-06-3

Formula: C7-H14-N2-O2-S

Synonyms/Common Names

  • Propanal, 2-methyl-2-(methylthio)-, oxime
  • TEMIK

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C08640)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C08640)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 5, 320, M: 0, .5, 40 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C08640)  Completed 
    • TR-136 (NIH Number: 79-1391)  (Peer Review Approval 12/13/1978A )
      Bioassay of Aldicarb for Possible Carcinogenicity (CASRN 116-06-3)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 2, 6 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (512453)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (145873)  Completed 
    • Citation: Mitchell AD, Rudd CJ, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International. Environ Mol Mutagen. 1988;12 Suppl 13:37-101. doi: 10.1002/em.2860120504
    • Mice
  • Mouse Lymphoma  (566841)  Completed 
    • Citation: Myhr BC, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ Mol Mutagen. 1988;12 Suppl 13:103-94. doi: 10.1002/em.2860120505
    • Mice
  • Salmonella  (087997)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen. 1988;11 Suppl 12:1-157
    •  Negative 
  • Salmonella  (N-9316)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248