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Testing Status of 1,3-Dichloro-5,5-dimethylhydantoin 10543-E

CASRN: 118-52-5

Formula: C5-H6-Cl2-N2-O2

Synonyms/Common Names

  • Dichlorodimethylhydantoin
  • 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione

Special Studies

  • Toxicokinetic Study (Gavage)  (S0153)  Completed 
    • Male Rats [R]: F344/N

Genetic Toxicology

  • Drosophila  (006881)  Completed 
    • Citation: Woodruff RC, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(5):677-702. doi: 10.1002/em.2860070507
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Drosophila  (220251)  Completed 
    • Citation: Zimmering S, Mason JM, Valencia R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ Mol Mutagen. 1989;14(4):245-51. doi: 10.1002/em.2850140406
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (807055)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (659873)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (695748)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Negative 

Organ Systems Toxicity

  • 7 to 14 GD (PLUG = 1 gestation day) Short-Term in vivo Repro. Tox. (Gavage)  (T0088)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 500 MG/KG BODY WEIGHT.