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Testing Status of 1,3-Dichloropropene (Telone II) 10560-H

CASRN: 542-75-6

Formula: C3-H4-Cl2

Synonyms/Common Names

  • 1,3-DCP
  • 1,3-Dichloro-1-propene

Short-Term Toxicity

  • 13-Week (Gavage)  (C03985)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C03985)  Completed 
    • TR-269 (NIH Number: 85-2525)  (Peer Review Approval 07/27/1984A )
      Toxicology and Carcinogenesis Studies of Telone® (Technical-Grade 1,3-Dichloropropane [CASRN 542-75-6] Containing 1.0 Epichlorohydrin as a Stabilizer) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 50, M: 0, 50, 100 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Some Evidence 
      • Male Mice Inadequate Study 
      • Female Mice Clear Evidence 

Genetic Toxicology

  • Chromosome Aberrations  (208737)  Completed 
    • Mice
    •  Positive 
  • Drosophila  (072802)  Completed 
    • Citation: Valencia R, Mason JM, Woodruff RC, Zimmering S. Chemical mutagenesis testing in Drosophila. III. Results of 48 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(3):325-48. doi: 10.1002/em.2860070309
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • In Vitro Cytogenetics (CA/SCE)  (129307)  Completed 
    • Citation: Loveday KS, Lugo MH, Resnick MA, Anderson BE, Zeiger E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals. Environ Mol Mutagen. 1989;13(1):60-94. doi: 10.1002/em.2850130108. Erratum in: Environ Mol Mutagen 1989;13(2):195
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (441206)  Completed 
    • Citation: Shelby MD, Erexson GL, Hook GJ, Tice RR. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen. 1993;21(2):160-79
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A15433)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Mouse Lymphoma  (725960)  Completed 
    • Citation: Myhr BC, Caspary WJ. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environ Mol Mutagen. 1991;18(1):51-83. doi: 10.1002/em.2850180109
    • Mice
    •  Positive 
  • Salmonella  (172972)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive 
  • Sister Chromatid Exchanges  (208737)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (IMM20201)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 62.5, 125, 250, 500, or 1000 PPM.