Testing Status of 2-Amino-5-nitrothiazole 10561-L
CASRN: 121-66-4
Formula: C3-H3-N3-O2-S
Synonyms/Common Names
- 5-Nitro-2-thiazolamine
Short-Term Toxicity
- 13 weeks (Dosed-Feed)
(C03065)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 375, 4000, M: 0, 30, 500 PPM/5 PER GROUP.
Long-Term Carcinogenicity
- 109 weeks (Dosed-Feed)
(C03065)
Completed
- TR-053 (NIH Number: 78-1359)
(Peer Review Approval 03/06/1978A )
Bioassay of 2-Amino-5-Nitrothiazole for Possible Carcinogenicity (CASRN 121-66-4) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0, 300, 600, M: 0, 50, 100 PPM/50 PER GROUP.
- TR-053 (NIH Number: 78-1359)
(Peer Review Approval 03/06/1978A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(365768)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Mouse Lymphoma
(G59371)
Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mice
- Mouse Lymphoma
(G77278)
Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mice
- Salmonella
(467333)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Positive
- Salmonella
(N-9199)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248