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Testing Status of 2-Amino-5-nitrothiazole 10561-L

CASRN: 121-66-4

Formula: C3-H3-N3-O2-S

Synonyms/Common Names

  • 5-Nitro-2-thiazolamine

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C03065)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 375, 4000, M: 0, 30, 500 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 109 weeks (Dosed-Feed)  (C03065)  Completed 
    • TR-053 (NIH Number: 78-1359)  (Peer Review Approval 03/06/1978A )
      Bioassay of 2-Amino-5-Nitrothiazole for Possible Carcinogenicity (CASRN 121-66-4)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 300, 600, M: 0, 50, 100 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (365768)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (G59371)  Completed 
    • Citation: Myhr BC, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ Mol Mutagen. 1988;12 Suppl 13:103-94. doi: 10.1002/em.2860120505
    • Mice
  • Mouse Lymphoma  (G77278)  Completed 
    • Citation: Mitchell AD, Rudd CJ, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International. Environ Mol Mutagen. 1988;12 Suppl 13:37-101. doi: 10.1002/em.2860120504
    • Mice
  • Salmonella  (467333)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen. 1992;19 Suppl 21:2-141. doi: 10.1002/em.2850190603
    •  Positive 
  • Salmonella  (N-9199)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248