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Testing Status of Propyl gallate 10564-Y

CASRN: 121-79-9

Formula: C10-H12-O5

Synonyms/Common Names

  • 3,4,5-Trihydroxybenzoic acid propylester (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50588)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50588)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1500, 25000, M: 0, 800, 12500 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50588)  Completed 
    • TR-240 (NIH Number: 82-1796)  (Peer Review Approval 12/16/1981A )
      Carcinogenesis Bioassay of Propyl Gallate (CASRN 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6000, 12000 PPM/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Negative 

Genetic Toxicology

  • Chromosome Aberrations  (299865)  Completed 
    • Citation: Shelby MD, Witt KL. Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests. Environ Mol Mutagen. 1995;25(4):302-13. doi: 10.1002/em.2850250407
    • Mice
    •  Positive 
  • Drosophila  (677217)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(1):51-63. doi: 10.1002/em.2850230109
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (257022)  Completed 
    • Citation: Gulati DK, Witt K, Anderson B, Zeiger E, Shelby MD. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Environ Mol Mutagen. 1989;13(2):133-93. doi: 10.1002/em.2850130208
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (512803)  Completed 
    • Citation: Shelby MD, Erexson GL, Hook GJ, Tice RR. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen. 1993;21(2):160-79
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A73992)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Mouse Lymphoma  (099874)  Completed 
    • Citation: McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. doi: 10.1002/em.2860120111. Erratum in: Environ Mol Mutagen 1988;12(3):345
    • Mice
    •  Positive 
  • Salmonella  (985325)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative 
  • Sister Chromatid Exchanges  (299865)  Completed 
    • Citation: Shelby MD, Witt KL. Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests. Environ Mol Mutagen. 1995;25(4):302-13. doi: 10.1002/em.2850250407
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)